Ni2+ [Ligand Id: 2476] activity data from GtoPdb

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  • CatSper1 in Mouse [GtoPdb: 388] [UniProtKB: Q91ZR5]
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  • CatSper2 in Mouse [GtoPdb: 389] [UniProtKB: A2ARP9]
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  • CatSper3 in Mouse [GtoPdb: 390] [UniProtKB: Q80W99]
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  • CatSper4 in Mouse [GtoPdb: 391] [UniProtKB: Q8BVN3]
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  • Cav2.3 in Human [GtoPdb: 534] [UniProtKB: Q15878]
  • Cav2.3 in Rat [GtoPdb: 534] [UniProtKB: Q07652]
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  • Cav3.1 in Rat [GtoPdb: 535] [UniProtKB: O54898]
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  • Cav3.2 in Human [GtoPdb: 536] [UniProtKB: O95180]
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  • Cav3.3 in Rat [GtoPdb: 537] [UniProtKB: Q9Z0Y8]
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  • ASIC1 in Human [GtoPdb: 684] [UniProtKB: P78348]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CatSper1 in Mouse [GtoPdb: 388] [UniProtKB: Q91ZR5]
GtoPdb Whole cell patch clamp - 3.5 pIC50 300000 nM IC50 Nature (2006) 439: 737-40 [PMID:16467839]
CatSper2 in Mouse [GtoPdb: 389] [UniProtKB: A2ARP9]
GtoPdb Whole cell patch clamp. - 3.5 pIC50 300000 nM IC50 Mol. Hum. Reprod. (2011) 17: 478-99 [PMID:21642646]
CatSper3 in Mouse [GtoPdb: 390] [UniProtKB: Q80W99]
GtoPdb Whole cell patch clamp electrophysiology. - 3.5 pIC50 300000 nM IC50 Nature (2006) 439: 737-40 [PMID:16467839]
CatSper4 in Mouse [GtoPdb: 391] [UniProtKB: Q8BVN3]
GtoPdb Whole cell patch clamp electrophysiology. - 3.5 pIC50 300000 nM IC50 Nature (2006) 439: 737-40 [PMID:16467839]
Cav2.3 in Human [GtoPdb: 534] [UniProtKB: Q15878]
GtoPdb - - 4.6 pIC50 27400 nM IC50 J. Biol. Chem. (1994) 269: 22347-57 [PMID:8071363]
Cav2.3 in Rat [GtoPdb: 534] [UniProtKB: Q07652]
GtoPdb - - 4.7 pIC50 - - - J. Membr. Biol. (1996) 151: 77-90 [PMID:8661496];
Science (1993) 260: 1133-6 [PMID:8388125]
Cav3.1 in Rat [GtoPdb: 535] [UniProtKB: O54898]
GtoPdb - - 3.8 pIC50 167000 nM IC50 Biophys. J. (1999) 77: 3034-42 [PMID:10585925]
Cav3.2 in Human [GtoPdb: 536] [UniProtKB: O95180]
GtoPdb - - 5.2 pIC50 5700 nM IC50 Biophys. J. (1999) 77: 3034-42 [PMID:10585925]
Cav3.3 in Rat [GtoPdb: 537] [UniProtKB: Q9Z0Y8]
GtoPdb - - 4.1 pIC50 87000 nM IC50 Biophys. J. (1999) 77: 3034-42 [PMID:10585925]
ASIC1 in Human [GtoPdb: 684] [UniProtKB: P78348]
GtoPdb - - 3.2 pIC50 ~600000 nM IC50

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.