Ni2+ [Ligand Id: 2476] activity data from GtoPdb

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  • CatSper1 in Mouse [GtoPdb: 388] [UniProtKB: Q91ZR5]
  • This target only has 0 pki data point
  • 0
1 _lig_chart_1 CatSper1 Mouse
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  • CatSper2 in Mouse [GtoPdb: 389] [UniProtKB: A2ARP9]
  • This target only has 0 pki data point
  • 0
2 _lig_chart_2 CatSper2 Mouse
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  • CatSper3 in Mouse [GtoPdb: 390] [UniProtKB: Q80W99]
  • This target only has 0 pki data point
  • 0
3 _lig_chart_3 CatSper3 Mouse
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  • CatSper4 in Mouse [GtoPdb: 391] [UniProtKB: Q8BVN3]
  • This target only has 0 pki data point
  • 0
4 _lig_chart_4 CatSper4 Mouse
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  • Cav2.3 in Human [GtoPdb: 534] [UniProtKB: Q15878]
  • Cav2.3 in Rat [GtoPdb: 534] [UniProtKB: Q07652]
  • This target only has 0 pki data point
  • 0
5 _lig_chart_5 Cav2.3 HumanRat
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  • Cav3.1 in Rat [GtoPdb: 535] [UniProtKB: O54898]
  • This target only has 0 pki data point
  • 0
6 _lig_chart_6 Cav3.1 Rat
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  • Cav3.2 in Human [GtoPdb: 536] [UniProtKB: O95180]
  • This target only has 0 pki data point
  • 0
7 _lig_chart_7 Cav3.2 Human
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  • Cav3.3 in Rat [GtoPdb: 537] [UniProtKB: Q9Z0Y8]
  • This target only has 0 pki data point
  • 0
8 _lig_chart_8 Cav3.3 Rat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CatSper1 in Mouse [GtoPdb: 388] [UniProtKB: Q91ZR5]
GtoPdb Whole cell patch clamp - 3.5 pIC50 300000 nM IC50 Nature (2006) 439: 737-40 [PMID:16467839]
CatSper2 in Mouse [GtoPdb: 389] [UniProtKB: A2ARP9]
GtoPdb Whole cell patch clamp. - 3.5 pIC50 300000 nM IC50 Mol Hum Reprod (2011) 17: 478-99 [PMID:21642646]
CatSper3 in Mouse [GtoPdb: 390] [UniProtKB: Q80W99]
GtoPdb Whole cell patch clamp electrophysiology. - 3.5 pIC50 300000 nM IC50 Nature (2006) 439: 737-40 [PMID:16467839]
CatSper4 in Mouse [GtoPdb: 391] [UniProtKB: Q8BVN3]
GtoPdb Whole cell patch clamp electrophysiology. - 3.5 pIC50 300000 nM IC50 Nature (2006) 439: 737-40 [PMID:16467839]
Cav2.3 in Human [GtoPdb: 534] [UniProtKB: Q15878]
GtoPdb - - 4.6 pIC50 27400 nM IC50 J Biol Chem (1994) 269: 22347-57 [PMID:8071363]
Cav2.3 in Rat [GtoPdb: 534] [UniProtKB: Q07652]
GtoPdb - - 4.7 pIC50 - - - J Membr Biol (1996) 151: 77-90 [PMID:8661496];
Science (1993) 260: 1133-6 [PMID:8388125]
Cav3.1 in Rat [GtoPdb: 535] [UniProtKB: O54898]
GtoPdb - - 3.8 pIC50 167000 nM IC50 Biophys J (1999) 77: 3034-42 [PMID:10585925]
Cav3.2 in Human [GtoPdb: 536] [UniProtKB: O95180]
GtoPdb - - 5.2 pIC50 5700 nM IC50 Biophys J (1999) 77: 3034-42 [PMID:10585925]
Cav3.3 in Rat [GtoPdb: 537] [UniProtKB: Q9Z0Y8]
GtoPdb - - 4.1 pIC50 87000 nM IC50 Biophys J (1999) 77: 3034-42 [PMID:10585925]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.