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ChEMBL ligand: CHEMBL65061 (Leukotriene B4) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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BLT1 receptor/Leukotriene B4 receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722] | ||||||||
ChEMBL | Displacement of [3H]LTB4 from LTB4R | B | 8.54 | pKi | 2.9 | nM | Ki | J Nat Prod (1993) 56: 441-455 [PMID:8496700] |
ChEMBL | Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor | B | 8.72 | pKi | 1.9 | nM | Ki | J Med Chem (1993) 36: 3982-3984 [PMID:8254628] |
ChEMBL | LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil | B | 8.72 | pKi | 1.9 | nM | Ki | Bioorg Med Chem Lett (1994) 4: 2077-2082 |
GtoPdb | - | - | 9.4 | pKi | 0.38 | nM | Ki | |
ChEMBL | Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor | B | 9.92 | pKi | 0.12 | nM | Ki | J Med Chem (1993) 36: 3982-3984 [PMID:8254628] |
ChEMBL | Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes | B | 9.92 | pKi | 0.12 | nM | Ki | Bioorg Med Chem Lett (1993) 3: 1981-1984 |
ChEMBL | LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes | B | 9.92 | pKi | 0.12 | nM | Ki | Bioorg Med Chem Lett (1994) 4: 2077-2082 |
ChEMBL | Inhibitory activity against leukotriene B4 receptor | B | 7.49 | pIC50 | 32 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 811-816 |
ChEMBL | In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils | B | 8.72 | pIC50 | 1.9 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 1981-1984 |
ChEMBL | Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils | B | 8.72 | pIC50 | 1.9 | nM | IC50 | J Med Chem (1990) 33: 2807-2813 [PMID:2170648] |
BLT2 receptor in Human [GtoPdb: 268] [UniProtKB: Q9NPC1] | ||||||||
GtoPdb | - | - | 7.64 | pKd | 22.7 | nM | Kd | J Exp Med (2000) 192: 421-32 [PMID:10934230] |
GtoPdb | - | - | 7.6 | pIC50 | 25 | nM | IC50 | J Exp Med (2008) 205: 759-66 [PMID:18378794] |
GtoPdb | - | - | 6.85 | pEC50 | 142 | nM | EC50 | J Exp Med (2008) 205: 759-66 [PMID:18378794] |
TRPV1 in Rat [GtoPdb: 507] [UniProtKB: O35433] | ||||||||
GtoPdb | - | - | 4.9 | pEC50 | 12500 | nM | EC50 | Proc Natl Acad Sci USA (2000) 97: 6155-60 [PMID:10823958] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]