ChEMBL ligand: CHEMBL29411 (3-hydroxy-p-cymene, Apiguard, Eftab, FEMA NO. 3066, Gppe mthwsh tab, Listerine, NSC-11215, NSC-47821, NSC-49142, P-cymen-3-ol, Sotol, Tellodont, Tellora, Thyme camphor, Thymol, Thymolum, Valda)
Heat sensitive channel TRPV3 in Rat [ChEMBL: CHEMBL3879847] [UniProtKB: Q4QYD9] There should be some charts here, you may need to enable JavaScript!
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] There should be some charts here, you may need to enable JavaScript!
TRPM8/Transient receptor potential cation channel subfamily M member 8 in Rat [ChEMBL: CHEMBL5011] [GtoPdb: 500] [UniProtKB: Q8R455] There should be some charts here, you may need to enable JavaScript!
TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Heat sensitive channel TRPV3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879847] [UniProtKB: Q4QYD9]
ChEMBL	Activation of rat TRPV3 overexpressed in HEK293 cells assessed as increase in 2-aminoethoxydiphenyl borate-induced intracellular calcium concentration by Fluo-4AM dye-based spectrofluorometry	B	4.54	pEC50	29000	nM	EC50	J Nat Prod (2016) 79: 1762-1768 [PMID:27352042]
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
ChEMBL	Agonist activity at TRPA1 (unknown origin) by calcium imaging assay	B	4.06	pEC50	86900	nM	EC50	Bioorg Med Chem Lett (2021) 31: 127639-127639 [PMID:33129991]
ChEMBL	Activation of TRPA1 channel	B	4.2	pEC50	62500	nM	EC50	J Med Chem (2010) 53: 5085-5107 [PMID:20356305]
ChEMBL	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay	B	4.22	pEC50	60255.96	nM	EC50	Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
ChEMBL	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay	B	4.22	pEC50	60000	nM	EC50	Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
ChEMBL	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by calcium-3 dye based FLIPR analysis	B	4.7	pEC50	20000	nM	EC50	Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
GtoPdb	FLIPR calcium influx assay	-	4.7	pEC50	20000	nM	EC50	Br J Pharmacol (2008) 153: 1739-49 [PMID:18334983]
ChEMBL	Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influx	F	5.22	pEC50	6000	nM	EC50	J Med Chem (2010) 53: 5085-5107 [PMID:20356305]
ChEMBL	Activation of human TRPA1 assessed as stimulation of intracellular Ca2+ levels	B	5.22	pEC50	6000	nM	EC50	Bioorg Med Chem Lett (2012) 22: 3535-3539 [PMID:22503249]
TRPM8/Transient receptor potential cation channel subfamily M member 8 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5011] [GtoPdb: 500] [UniProtKB: Q8R455]
ChEMBL	Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levels	B	4.28	pEC50	52200	nM	EC50	Bioorg Med Chem Lett (2012) 22: 3535-3539 [PMID:22503249]
TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424]
GtoPdb	Patch clamp electrophysiology	-	3.3	pEC50	-	-	-	Nat Neurosci (2006) 9: 628-35 [PMID:16617338]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]