thymol [Ligand Id: 2499] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL29411 (NSC-49142, Gppe mthwsh tab, NSC-47821, Thymol, NSC-11215, Listerine, Sotol, Valda, Tellodont, FEMA NO. 3066, Eftab, Tellora)
There should be some charts here, you may need to enable JavaScript!
  • TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
There should be some charts here, you may need to enable JavaScript!
  • TRPM8/Transient receptor potential cation channel subfamily M member 8 in Rat [ChEMBL: CHEMBL5011] [GtoPdb: 500] [UniProtKB: Q8R455]
There should be some charts here, you may need to enable JavaScript!
  • TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Heat sensitive channel TRPV3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879847] [UniProtKB: Q4QYD9]
ChEMBL Activation of rat TRPV3 overexpressed in HEK293 cells assessed as increase in 2-aminoethoxydiphenyl borate-induced intracellular calcium concentration by Fluo-4AM dye-based spectrofluorometry B 4.54 pEC50 29000 nM EC50 J Nat Prod (2016) 79: 1762-1768 [PMID:27352042]
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
ChEMBL Activation of TRPA1 channel B 4.2 pEC50 62500 nM EC50 J. Med. Chem. (2010) 53: 5085-5107 [PMID:20356305]
ChEMBL Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay B 4.22 pEC50 60255.96 nM EC50 Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
ChEMBL Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay B 4.22 pEC50 60000 nM EC50 Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
ChEMBL Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by calcium-3 dye based FLIPR analysis B 4.7 pEC50 20000 nM EC50 Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
GtoPdb FLIPR calcium influx assay - 4.7 pEC50 20000 nM EC50 Br J Pharmacol (2008) 153: 1739-49 [PMID:18334983]
ChEMBL Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influx F 5.22 pEC50 6000 nM EC50 J. Med. Chem. (2010) 53: 5085-5107 [PMID:20356305]
ChEMBL Activation of human TRPA1 assessed as stimulation of intracellular Ca2+ levels B 5.22 pEC50 6000 nM EC50 Bioorg. Med. Chem. Lett. (2012) 22: 3535-3539 [PMID:22503249]
TRPM8/Transient receptor potential cation channel subfamily M member 8 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5011] [GtoPdb: 500] [UniProtKB: Q8R455]
ChEMBL Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levels B 4.28 pEC50 52200 nM EC50 Bioorg. Med. Chem. Lett. (2012) 22: 3535-3539 [PMID:22503249]
TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424]
GtoPdb Patch clamp electrophysiology - 3.3 pEC50 - - - Nat Neurosci (2006) 9: 628-35 [PMID:16617338]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]