clofilium [Ligand Id: 2507] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL9484
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  • K2P5.1 in Mouse [GtoPdb: 517]
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  • Kv1.5 in Human [GtoPdb: 542] [UniProtKB: P22460]
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  • Kv10.1 in Human [GtoPdb: 570] [UniProtKB: O95259]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibitory concentration against IKr potassium channel B 6.82 pIC50 150 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 4771-4777 [PMID:15324906]
ChEMBL Inhibition of human ERG B 7.9 pIC50 12.59 nM IC50 Eur. J. Med. Chem. (2011) 46: 618-630 [PMID:21185626]
K2P5.1 in Mouse [GtoPdb: 517]
GtoPdb - - 4.6 pIC50 - - - J Biol Chem (2001) 276: 43166-74 [PMID:11560934]
Kv1.5 in Human [GtoPdb: 542] [UniProtKB: P22460]
GtoPdb - - 6.9 pIC50 - - - Mol Pharmacol (1995) 47: 198-205 [PMID:7838129]
Kv10.1 in Human [GtoPdb: 570] [UniProtKB: O95259]
GtoPdb - - 6.6 pIC50 - - - Br J Pharmacol (2003) 138: 161-71 [PMID:12522086]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]