ChEMBL ligand: CHEMBL170 ((8s,9r)-6'-methoxycinchonan-9-ol, Chininum purum, NSC-192949, Quinine, Rezquin, WR297608)
ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum 3D7 [ChEMBL: CHEMBL2366922] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] Organic cation transporter 1/Solute carrier family 22 member 1 in Mouse [ChEMBL: CHEMBL2073664] [GtoPdb: 1019] [UniProtKB: O08966] Organic cation transporter 1/Solute carrier family 22 member 1 in Rat [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 2/Solute carrier family 22 member 2 in Human [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244] Organic cation transporter 2/Solute carrier family 22 member 2 in Mouse [ChEMBL: CHEMBL2073662] [GtoPdb: 1020] [UniProtKB: O70577] Organic cation transporter 2/Solute carrier family 22 member 2 in Rat [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2] There should be some charts here, you may need to enable JavaScript!
Solute carrier organic anion transporter family member 1A1 in Rat [ChEMBL: CHEMBL1781859] [UniProtKB: P46720] There should be some charts here, you may need to enable JavaScript!
Solute carrier organic anion transporter family member 1A4 in Rat [ChEMBL: CHEMBL1781860] [UniProtKB: O35913] There should be some charts here, you may need to enable JavaScript!
Kv2.2 in Human [GtoPdb: 547] [UniProtKB: Q92953] There should be some charts here, you may need to enable JavaScript!
Plasma membrane monoamine transporter in Human [GtoPdb: 1120] [UniProtKB: Q7RTT9] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum purine nucleoside phosphorylase in Plasmodium falciparum [GtoPdb: 3077] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL	High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity model	B	4.92	pKi	12000	nM	Ki	J Med Chem (2002) 45: 5671-5686 [PMID:12477351]
ChEMBL	TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells	F	4.06	pIC50	87600	nM	IC50	Biochem Biophys Res Commun (2001) 289: 580-585 [PMID:11716514]
ChEMBL	TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells	F	4.13	pIC50	74400	nM	IC50	Biochem Biophys Res Commun (2001) 289: 580-585 [PMID:11716514]
ChEMBL	TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells	F	4.65	pIC50	22600	nM	IC50	Biochem Biophys Res Commun (2001) 289: 580-585 [PMID:11716514]
ChEMBL	Inhibition of P-gp-mediated Rhodamine-123 efflux in human MCF-7/DOX cells assessed as Rhodamine-123 accumulation preincubated for 15 mins followed by Rhodamine-123 addition measured after 0.5 to 4 hrs by fluorescence assay	B	5.77	pIC50	1700	nM	IC50	Eur J Med Chem (2019) 176: 268-291 [PMID:31103904]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimicrobial activity against Plasmodium falciparum	F	4.27	pIC50	54000	nM	IC50	Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09N40 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	5.67	pIC50	2123	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum IMT K14 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	5.88	pIC50	1310	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09A41 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	5.89	pIC50	1295	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F08B61 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	5.95	pIC50	1128	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F08B7 harboring pfnhe1 ms4760 haplotype 9 carrying 3 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	5.96	pIC50	1099	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against schizont stage of atovaquone-resistant Plasmodium falciparum Tm90C2b infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis	F	5.97	pIC50	1068	nM	IC50	Medchemcomm (2011) 2: 430-435
ChEMBL	Antimicrobial activity against Plasmodium falciparum IMT 9996 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	5.98	pIC50	1039	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimicrobial activity against Plasmodium falciparum IMT K4 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	5.99	pIC50	1034	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F08B2 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	5.99	pIC50	1016	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K14 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.01	pIC50	969	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.02	pIC50	953	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against schizont stage of chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis	F	6.04	pIC50	917	nM	IC50	Medchemcomm (2011) 2: 430-435
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09N35 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.04	pIC50	905	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-46 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.05	pIC50	894	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F08B41 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.05	pIC50	886	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-3 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.06	pIC50	875	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-8 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.06	pIC50	874	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F08B27 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.06	pIC50	870	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09N29 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.07	pIC50	853	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 9 carrying 3 copies of DNNND repeat and His/Asp ratio 7:6 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.08	pIC50	837	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against Plasmodium falciparum after 48 hrs	F	6.08	pIC50	826	nM	IC50	Eur J Med Chem (2016) 112: 270-279 [PMID:26900659]
ChEMBL	Antimalarial activity against synchronized ring stage chloroquine-sensitive Plasmodium falciparum assessed as parasite growth inhibition incubated for 48 hrs in presence of 10% human plasma by hypoxanthine assay	F	6.08	pIC50	826	nM	IC50	Bioorg Med Chem Lett (2021) 38: 127855-127855 [PMID:33609655]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-35 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.09	pIC50	821	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 14 carrying 3 copies of DNNND repeat and His/Asp ratio 6:6 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.12	pIC50	767	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F08B60 harboring pfnhe1 ms4760 haplotype 14 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.12	pIC50	767	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum ms4760-7 assessed as growth inhibition after 48 hrs by scintillation counting	F	6.12	pIC50	764	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimicrobial activity against Plasmodium falciparum W2 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.14	pIC50	720	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09A10 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.15	pIC50	716	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09N66 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.15	pIC50	711	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09N6 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.15	pIC50	710	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum Bres infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.16	pIC50	688.7	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimicrobial activity against Plasmodium falciparum W2 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	6.16	pIC50	686	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.17	pIC50	683.9	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-58 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.17	pIC50	680	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.17	pIC50	670	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum FCR3 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.18	pIC50	665.3	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND repeat and His/Asp ratio 5:6 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.18	pIC50	661	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-27 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.19	pIC50	650	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCR3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.19	pIC50	650	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-11 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.2	pIC50	629	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum PA infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.2	pIC50	626.6	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimicrobial activity against Plasmodium falciparum PA harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	6.2	pIC50	625	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum K2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.21	pIC50	619.4	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimicrobial activity against Plasmodium falciparum 7G8 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034C 1042D 1246Y and pfcrt 72-76 SVMNT 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.21	pIC50	619	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against schizont stage of atovaquone-resistant Plasmodium falciparum Tm90C2b infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis	F	6.22	pIC50	608	nM	IC50	Medchemcomm (2011) 2: 430-435
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.22	pIC50	607	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimicrobial activity against Plasmodium falciparum IMT A4 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	6.22	pIC50	605	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Bres assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.22	pIC50	604	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimicrobial activity against Plasmodium falciparum Dd2 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.22	pIC50	602	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum IMT K2 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	6.22	pIC50	599	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimalarial activity against schizont stage of chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis	F	6.23	pIC50	583	nM	IC50	Medchemcomm (2011) 2: 430-435
ChEMBL	Antimicrobial activity against Plasmodium falciparum F08B72 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.23	pIC50	583	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum ms4760-6 assessed as growth inhibition after 48 hrs by scintillation counting	F	6.24	pIC50	582	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND repeat and His/Asp ratio 5:4 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.24	pIC50	580	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum FCM29 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	6.24	pIC50	580	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F08B63 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.24	pIC50	579	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum IMT L1 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	6.24	pIC50	575	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-34 harboring pfnhe1 ms4760 haplotype 9 carrying 3 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.24	pIC50	574	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against Plasmodium falciparum PA assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.24	pIC50	571	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum PA infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.24	pIC50	571	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK127	F	6.24	pIC50	569.5	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09A9 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.25	pIC50	562	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK182	F	6.26	pIC50	549.2	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum FCM29 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.26	pIC50	543.3	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT A4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.27	pIC50	543	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT L1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.27	pIC50	543	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTL1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.27	pIC50	543	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-6 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.27	pIC50	543	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCM29 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.27	pIC50	538	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09N22 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.27	pIC50	535	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum L1 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.27	pIC50	530.9	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09N44 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.29	pIC50	514	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09N78 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.29	pIC50	513	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-25 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.3	pIC50	502	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09N72 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.3	pIC50	500	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum IMT Bres harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	6.3	pIC50	500	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum K14 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.3	pIC50	495.5	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK227	F	6.31	pIC50	495.3	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum W2 by ELISA	F	6.31	pIC50	490.8	nM	IC50	Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09N33 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.31	pIC50	490	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09N64 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.32	pIC50	475	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-28 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.33	pIC50	473	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F08B53 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.33	pIC50	468	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotypes 5,34 carrying4 copies of DNNND repeat and His/Asp ratio 5:8 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.34	pIC50	462	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-7 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.34	pIC50	456	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum IMT 6311 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	6.34	pIC50	453	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09N58 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.35	pIC50	448	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-23 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.35	pIC50	447	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-31 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.36	pIC50	433	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum SRIV35	F	6.37	pIC50	431	nM	IC50	Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTVo1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.37	pIC50	428	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Vol assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.37	pIC50	428	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-56 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.37	pIC50	427	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum Voll infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.37	pIC50	421.7	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimicrobial activity against Plasmodium falciparum IMT Vol harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	6.38	pIC50	421	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2/Indochina by [3H]hypoxanthine uptake	F	6.38	pIC50	413	nM	IC50	J Nat Prod (2002) 65: 1381-1386 [PMID:12398531]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 Indochina by [3H]hypoxanthine uptake	F	6.38	pIC50	413	nM	IC50	J Nat Prod (2001) 64: 12-16 [PMID:11170658]
ChEMBL	Antimicrobial activity against Plasmodium falciparum K1 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.39	pIC50	407	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-42 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.41	pIC50	388	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Inhibitory activity against Plasmodium falciparum Dd2 in erythrocytes	F	6.42	pIC50	380	nM	IC50	Bioorg Med Chem Lett (2001) 11: 423-424 [PMID:11212126]
ChEMBL	Inhibitory concentration against multidrug-resistant Plasmodium falciparum Dd2.	F	6.42	pIC50	380	nM	IC50	Bioorg Med Chem Lett (2002) 12: 2681-2683 [PMID:12217353]
ChEMBL	Inhibition against Plasmodium falciparum Dd2 in erythrocytes in semiautomated micro dilution assay	F	6.42	pIC50	380	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2159-2161 [PMID:12798326]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 in erythrocytes	F	6.42	pIC50	380	nM	IC50	Bioorg Med Chem Lett (2002) 12: 543-545 [PMID:11844668]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09A61 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.43	pIC50	373	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum IMT 31 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	6.43	pIC50	371	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimicrobial activity against Plasmodium falciparum Feng harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.43	pIC50	371	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum W2 in human erythrocytes by [3H]hypoxanthine uptake	F	6.43	pIC50	370	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1351-1355 [PMID:11992775]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-13 harboring pfnhe1 ms4760 haplotype 3 carrying 1 copy of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.44	pIC50	365	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum FCR3 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	6.48	pIC50	334	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate CDA-1553	F	6.48	pIC50	333.3	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-47 harboring pfnhe1 ms4760 haplotype 20 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.49	pIC50	324	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Guy assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.49	pIC50	322	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-9 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.49	pIC50	321	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by 1536-well format based SYBR green assay	F	6.49	pIC50	320	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antimalarial activity against chloroquine resistant Plasmodium falciparum Dd2 after 72 hrs by SYBP Green I dye staining	F	6.49	pIC50	320	nM	IC50	Bioorg Med Chem (2012) 20: 3292-3297 [PMID:22512909]
ChEMBL	Antimicrobial activity against Plasmodium falciparum HB3 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042D 1246D and pfcrt 72-76 CVMNK 220A infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.5	pIC50	319	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.5	pIC50	314	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT10500 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.5	pIC50	314	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotypes1,18 carrying 2 copies of DNNND repeat and His/Asp ratio 7:4 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.51	pIC50	312	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-10 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.51	pIC50	306	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F08B32 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.52	pIC50	302	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by 96-well format based SYBR green assay	F	6.52	pIC50	300	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antimicrobial activity against Plasmodium falciparum PF18 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 SVMNT 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.52	pIC50	300	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-40 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220A infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.53	pIC50	298	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK150 D-0	F	6.53	pIC50	296.6	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.54	pIC50	290	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09N68 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.54	pIC50	288	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09N18 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.55	pIC50	284	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-29 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.55	pIC50	282	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 31 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.57	pIC50	272	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimicrobial activity against Plasmodium falciparum IMT 10336 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	6.57	pIC50	271	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK249	F	6.57	pIC50	270.4	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK121	F	6.57	pIC50	270.2	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.57	pIC50	270	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCA 20/ Ghana by [3H]hypoxanthine uptake	F	6.57	pIC50	269	nM	IC50	J Nat Prod (2002) 65: 1381-1386 [PMID:12398531]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCA 20 Ghana by [3H]hypoxanthine uptake	F	6.57	pIC50	269	nM	IC50	J Nat Prod (2001) 64: 12-16 [PMID:11170658]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCR3 infected in human erythrocytes by Giemsa staining analysis	F	6.57	pIC50	267.92	nM	IC50	Bioorg Med Chem (2019) 27: 3574-3586 [PMID:31272837]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F08B40 harboring pfnhe1 ms4760 haplotype 21 carrying 1 copy of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.59	pIC50	260	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 35 carrying 1 copy of DNNND repeat and His/Asp ratio 5:2 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.59	pIC50	260	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09A21 harboring pfnhe1 ms4760 haplotype 18 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.59	pIC50	258	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum Dd2 infected in human erythrocytes by SYBR green 1-based fluorescence assay	F	6.6	pIC50	254	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs	F	6.6	pIC50	250	nM	IC50	J Nat Prod (1999) 62: 59-66 [PMID:9917283]
ChEMBL	Antimalarial activity against Plasmodium falciparum harboring pfmdr1-86 mutant gene with 2 DNNND repeat	F	6.6	pIC50	249	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09A54 harboring pfnhe1 ms4760 haplotype 3 carrying 1 copy of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.61	pIC50	243	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.62	pIC50	240	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimicrobial activity against chloroquine-resistant Plasmodium falciparum HB3 by ELISA	F	6.63	pIC50	236.1	nM	IC50	Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK158	F	6.63	pIC50	234	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum harboring pfcrt-76 mutant gene with 2 DNNND repeat	F	6.63	pIC50	234	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK167	F	6.64	pIC50	227	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum harboring 2 DNNND repeat	F	6.64	pIC50	227	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 3 carrying 1 copy of DNNND repeat and His/Asp ratio 6:2 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.65	pIC50	223	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCM29 by SYBR green assay	F	6.66	pIC50	220	nM	IC50	Bioorg Med Chem (2009) 17: 2871-2876 [PMID:19282186]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F08B9 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.66	pIC50	218	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring V259L mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	6.67	pIC50	215	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antimalarial activity against Plasmodium falciparum harboring pfcrt gene with 2 DNNND repeat	F	6.68	pIC50	211	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK222	F	6.68	pIC50	210.5	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimicrobial activity against Plasmodium falciparum IMT 10500 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	6.68	pIC50	210	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimalarial activity against Plasmodium falciparum harboring pfmdr1 gene	F	6.68	pIC50	208	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK152 D-56	F	6.68	pIC50	207.7	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-50 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.69	pIC50	204	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum IMT 16116 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	6.69	pIC50	204	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCB1-R/Colombia by [3H]hypoxanthine uptake	F	6.7	pIC50	200	nM	IC50	J Nat Prod (2002) 65: 1381-1386 [PMID:12398531]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring M133I/A138T double mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	6.7	pIC50	199	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum SKF58	F	6.7	pIC50	199	nM	IC50	Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring M133I mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	6.71	pIC50	197	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F07-59 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.71	pIC50	197	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09N1 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.72	pIC50	191	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum SM harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.73	pIC50	188	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against Plasmodium falciparum harboring 1 DNNND repeat	F	6.74	pIC50	182	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK062	F	6.74	pIC50	181.5	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum Nigerian assessed as [3H]hypoxanthine uptake after 48 hrs by liquid scintillation counting	F	6.74	pIC50	180	nM	IC50	Eur J Med Chem (2009) 44: 4778-4782 [PMID:19747753]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in erythrocytes measured after 48 hrs by Malstat/nitroblue tetrazolium/phenazine ethosulphate reagent based LDH assay	F	6.74	pIC50	180	nM	IC50	Bioorg Med Chem Lett (2017) 27: 460-465 [PMID:28027871]
ChEMBL	Antimicrobial activity against Plasmodium falciparum FCC1/HN harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.75	pIC50	179	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against Plasmodium falciparum ms4760-3 assessed as growth inhibition after 48 hrs by scintillation counting	F	6.75	pIC50	178	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimicrobial activity against Plasmodium falciparum ms4760-2 assessed as growth inhibition after 48 hrs by scintillation counting	F	6.75	pIC50	178	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimalarial activity against Plasmodium falciparum harboring pfcrt-76 mutant gene	F	6.79	pIC50	164	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by 1536-well format based SYBR green assay	F	6.8	pIC50	160	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by 1536-well format based SYBR green assay	F	6.8	pIC50	160	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antimicrobial activity against Plasmodium falciparum F09A55 harboring pfnhe1 ms4760 haplotype 3 carrying 1 copy of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.83	pIC50	149	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by pLDH assay	F	6.83	pIC50	149	nM	IC50	Bioorg Med Chem Lett (2007) 17: 3599-3602 [PMID:17482816]
ChEMBL	Antimicrobial activity against Plasmodium falciparum IMT 8425 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	6.83	pIC50	148	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK144	F	6.84	pIC50	145.8	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum harboring pfcrt gene	F	6.85	pIC50	142	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK018	F	6.85	pIC50	141.1	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum harboring 1 DDNHNDHHNND repeat	F	6.85	pIC50	141	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of [3H] hypoxanthine incorporation after 24 hrs by scintillation counting	F	6.85	pIC50	140	nM	IC50	Eur J Med Chem (2011) 46: 1897-1905 [PMID:21377771]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by 96-well format based SYBR green assay	F	6.85	pIC50	140	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.86	pIC50	138	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against Plasmodium falciparum 106/1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.87	pIC50	135	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.87	pIC50	134	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum VS/1 by [3H]hypoxanthine incorporation assay	F	6.88	pIC50	133	nM	IC50	Antimicrob Agents Chemother (2009) 53: 3131-3134 [PMID:19364853]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 8425 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.89	pIC50	130.3	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by 1536-well format based SYBR green assay	F	6.89	pIC50	130	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by 1536-well format based SYBR green assay	F	6.89	pIC50	130	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antimicrobial activity against Plasmodium falciparum 3D7 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	6.89	pIC50	128	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by 96-well format based SYBR green assay	F	6.92	pIC50	120	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	In vitro inhibition of parasite development of Plasmodium falciparum W2 in human erythrocytes	F	6.92	pIC50	120	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1351-1355 [PMID:11992775]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 10354 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.93	pIC50	118	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by 96-well format based SYBR green assay	F	6.96	pIC50	110	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antimalarial activity against Plasmodium falciparum HB3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.96	pIC50	109	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in erythrocytes assessed as reduction in parasite growth incubated for 48 hrs by lactate dehydrogenase assay	F	6.97	pIC50	108	nM	IC50	Eur J Med Chem (2021) 217: 113330-113330 [PMID:33744688]
ChEMBL	Antimicrobial activity against Plasmodium falciparum 3D7 harboring pfnhe1 ms4760 haplotype 2 carrying 1 copy of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVMNK 220A infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay	F	6.97	pIC50	108	nM	IC50	Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum D6 by ELISA	F	6.97	pIC50	106.9	nM	IC50	Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolates assessed as parasite growth inhibition after 72 hrs by ELISA based histidine-rich protein 2 in vitro drug susceptibility assay	F	6.98	pIC50	105.68	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4040-4042 [PMID:19596882]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.98	pIC50	103.8	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Inhibitory concentration against Plasmodium falciparum W2 infected erythrocytes	F	7	pIC50	100	nM	IC50	J Med Chem (1994) 37: 1486-1494 [PMID:8182707]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 48 hrs by pLDH assay	F	7.01	pIC50	96.8	nM	IC50	Bioorg Med Chem Lett (2007) 17: 3599-3602 [PMID:17482816]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 in erythrocytes	F	7.02	pIC50	96	nM	IC50	Bioorg Med Chem Lett (2002) 12: 543-545 [PMID:11844668]
ChEMBL	Antimicrobial activity against Plasmodium falciparum by ELISA	F	7.03	pIC50	94.4	nM	IC50	Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	Antimalarial activity against Plasmodium falciparum harboring pfmdr1 gene with 2 DNNND repeat	F	7.04	pIC50	92	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK150 D-42	F	7.04	pIC50	91.6	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimicrobial activity against Plasmodium falciparum IMT 16332 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	7.08	pIC50	83	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimalarial activity against chloroquine sensitive Plasmodium falciparum HB3 after 72 hrs by SYBP Green I dye staining	F	7.09	pIC50	81	nM	IC50	Bioorg Med Chem (2012) 20: 3292-3297 [PMID:22512909]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate 9067	F	7.1	pIC50	80.1	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by 1536-well format based SYBR green assay	F	7.1	pIC50	80	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by 1536-well format based SYBR green assay	F	7.1	pIC50	80	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate 8885	F	7.11	pIC50	78.2	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimicrobial activity against wild type Plasmodium falciparum HB3 infected in erythrocytes assessed as growth inhibition after 72 hrs by SYBR Green I-based fluorescence assay	F	7.11	pIC50	77.13	nM	IC50	Antimicrob Agents Chemother (2008) 52: 2346-2354 [PMID:18443109]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 72 hrs by pLDH assay	F	7.12	pIC50	75.3	nM	IC50	Bioorg Med Chem Lett (2007) 17: 3599-3602 [PMID:17482816]
ChEMBL	Antimalarial activity against Plasmodium falciparum harboring pfmdr1-86 mutant gene	F	7.13	pIC50	74	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimicrobial activity against leupeptin resistant-Plasmodium falciparum HB3-leuR1 mutant infected in erythrocytes assessed as growth inhibition after 72 hrs by SYBR Green I-based fluorescence assay	F	7.13	pIC50	73.96	nM	IC50	Antimicrob Agents Chemother (2008) 52: 2346-2354 [PMID:18443109]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK183	F	7.13	pIC50	73.9	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by pLDH assay	F	7.13	pIC50	73.5	nM	IC50	Bioorg Med Chem Lett (2007) 17: 3599-3602 [PMID:17482816]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate 6816	F	7.13	pIC50	73.3	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring SVMNT genotype after 72 hrs by SYBR green I assay	F	7.15	pIC50	70	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2042-2051 [PMID:19258269]
ChEMBL	Growth inhibition of Plasmodium falciparum ring stage in infected erythrocytes by DAPI growth assay	F	7.16	pIC50	69.19	nM	IC50	Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676]
ChEMBL	Growth inhibition of Plasmodium falciparum ring stage in infected erythrocytes by DAPI growth assay	F	7.18	pIC50	66.52	nM	IC50	Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring CVMNT genotype after 72 hrs by SYBR green I assay	F	7.18	pIC50	66	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2042-2051 [PMID:19258269]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7A asexual forms assessed as inhibition of [G-3H]hypoxanthine uptake incubated for 24 hrs followed by [G-3H]hypoxanthine addition and measured after 18 hrs by liquid scintillation spectrometry	F	7.18	pIC50	66	nM	IC50	Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292]
ChEMBL	Growth inhibition of Plasmodium falciparum as reduced [3H]hypoxanthine incorporation	F	7.2	pIC50	62.77	nM	IC50	Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676]
ChEMBL	Antimicrobial activity against Plasmodium falciparum D6 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	7.21	pIC50	62	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum D6 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	7.21	pIC50	61.8	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 in MSF assay	F	7.22	pIC50	60	nM	IC50	Bioorg Med Chem (2008) 16: 1174-1183 [PMID:18023189]
ChEMBL	Antimicrobial activity against Plasmodium falciparum IMT 10354 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	7.24	pIC50	58	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimicrobial activity against Plasmodium falciparum IMT 9881 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting	F	7.24	pIC50	57	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate 8966	F	7.25	pIC50	55.8	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK033 D-49	F	7.27	pIC50	54.1	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum assessed as parasite growth inhibition after 48 hrs by [3H]hypoxanthin incorporation assay	F	7.27	pIC50	53.7	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4588-4597 [PMID:19704124]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCM29 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCR3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum PA assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum HB3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum 106/1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Bres assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Guy assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT A4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 31 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Inhibitory concentration against Plasmodium falciparum D6 infected erythrocytes	F	7.32	pIC50	48	nM	IC50	J Med Chem (1994) 37: 1486-1494 [PMID:8182707]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K14 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Vol assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT L1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum harboring 3 DNNND repeat	F	7.35	pIC50	45	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK022D-0	F	7.37	pIC50	42.4	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate 9070	F	7.38	pIC50	41.5	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by 96-well format based SYBR green assay	F	7.4	pIC50	40	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by 96-well format based SYBR green assay	F	7.44	pIC50	36	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate 8977	F	7.44	pIC50	35.9	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK033 D-0	F	7.48	pIC50	32.8	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by 96-well format based SYBR green assay	F	7.51	pIC50	31	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate 8968	F	7.51	pIC50	30.6	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate 8948	F	7.56	pIC50	27.8	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7	F	7.57	pIC50	27.1	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs	F	7.63	pIC50	23.38	nM	IC50	J Nat Prod (1999) 62: 59-66 [PMID:9917283]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate AK022 D-28	F	7.66	pIC50	22	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolate 8973	F	7.7	pIC50	20	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antiplasmodial against chloroquine-rsistant Plasmodium falciparum W2 after 2 days by flow cytometry	F	7.73	pIC50	18.7	nM	IC50	Eur J Med Chem (2012) 57: 259-267 [PMID:23064162]
ChEMBL	Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 assessed as parasitemia after 48 hrs by flow cytometry	F	7.73	pIC50	18.67	nM	IC50	Eur J Med Chem (2014) 71: 128-134 [PMID:24287561]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR Green-1 staining based fluorescence assay	F	7.74	pIC50	18	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR Green-1 staining based fluorescence assay	F	7.74	pIC50	18	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring mdr1 N86Y/D1246Y/Y184F mutant gene by ELISA	F	7.81	pIC50	15.4	nM	IC50	Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 in MSF assay	F	7.96	pIC50	11	nM	IC50	Bioorg Med Chem (2008) 16: 1174-1183 [PMID:18023189]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT K2 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	8.17	pIC50	6.7	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCM29 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	8.24	pIC50	5.8	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antiplasmodial against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation after 24 hrs by scintillation counting	F	9.15	pIC50	0.7	nM	IC50	Eur J Med Chem (2012) 57: 259-267 [PMID:23064162]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum FCR3	F	6.96	pEC50	110	nM	EC50	Bioorg Med Chem Lett (2004) 14: 1689-1692 [PMID:15026051]
ChEMBL	In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3	F	6.96	pEC50	110	nM	EC50	J Med Chem (2002) 45: 995-998 [PMID:11855978]
ChEMBL	In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3	F	6.96	pEC50	110	nM	EC50	Bioorg Med Chem Lett (2000) 10: 1657-1659 [PMID:10937718]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3	F	6.96	pEC50	110	nM	EC50	Bioorg Med Chem Lett (2006) 16: 2758-2760 [PMID:16524728]
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as reduction in parasite viability by parasite lactate dehydrogenase assay	F	6.2	pIC50	632.7	nM	IC50	Eur J Med Chem (2015) 100: 10-17 [PMID:26063305]
ChEMBL	Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis	F	6.75	pIC50	178	nM	IC50	Medchemcomm (2011) 2: 430-435
ChEMBL	Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis	F	6.95	pIC50	112	nM	IC50	Medchemcomm (2011) 2: 430-435
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	7.1	pIC50	80	nM	IC50	Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL	Antimalarial activity against blood stage Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in parasitemia after 72 hrs by SYBR green I fluorescence-based method	F	7.24	pIC50	58	nM	IC50	Bioorg Med Chem (2016) 24: 3527-3539 [PMID:27298002]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method	F	7.47	pIC50	34	nM	IC50	Med Chem Res (2007) 16: 213-229
ChEMBL	Antiplasmodial activity against CQ-sensitive Plasmodium falciparum 3D7	F	7.74	pIC50	18	nM	IC50	Bioorg Med Chem (2015) 23: 5098-5119 [PMID:25593097]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL	Antimicrobial activity against chloroquine-resistant Plasmodium falciparum K1 by ELISA	F	6.56	pIC50	276	nM	IC50	Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.95	pIC50	113	nM	IC50	Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by [G-3H]hypoxanthine uptake	F	7.09	pIC50	81	nM	IC50	Eur J Med Chem (2008) 43: 2840-2852 [PMID:18395298]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method	F	7.09	pIC50	81	nM	IC50	Med Chem Res (2007) 16: 213-229
ChEMBL	Antiplasmodial against chloroquine-rsistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation after 24 hrs by scintillation counting	F	7.69	pIC50	20.4	nM	IC50	Eur J Med Chem (2012) 57: 259-267 [PMID:23064162]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1	F	7.92	pIC50	12	nM	IC50	Eur J Med Chem (2009) 44: 2731-2735 [PMID:19084293]
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing HeLa cells	F	4.64	pKi	22900	nM	Ki	J Pharmacol Exp Ther (1998) 286: 354-361 [PMID:9655880]
ChEMBL	Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy	B	4.29	pIC50	51600	nM	IC50	J Med Chem (2008) 51: 5932-5942 [PMID:18788725]
Organic cation transporter 1/Solute carrier family 22 member 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073664] [GtoPdb: 1019] [UniProtKB: O08966]
ChEMBL	TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes	F	6.55	pIC50	280	nM	IC50	Biochem Biophys Res Commun (2002) 296: 644-650 [PMID:12176030]
Organic cation transporter 1/Solute carrier family 22 member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089]
ChEMBL	TP_TRANSPORTER: inhibition of MPP+ uptake in OCT1-expressing HEK293 cells	F	5.37	pKi	4300	nM	Ki	Naunyn Schmiedebergs Arch Pharmacol (1996) 354: 320-326 [PMID:8878062]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes	F	6.03	pKi	930	nM	Ki	Nature (1994) 372: 549-552 [PMID:7990927]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes	F	5.39	pIC50	4100	nM	IC50	Am J Physiol Renal Physiol (2001) 281: F454-F468 [PMID:11502595]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake (in the absence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cells	F	5.96	pIC50	1100	nM	IC50	J Pharmacol Exp Ther (2002) 303: 959-968 [PMID:12438515]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cells	F	6.05	pIC50	900	nM	IC50	J Pharmacol Exp Ther (2002) 303: 959-968 [PMID:12438515]
Organic cation transporter 2/Solute carrier family 22 member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes	F	5.47	pKi	3400	nM	Ki	DNA Cell Biol (1997) 16: 871-881 [PMID:9260930]
Organic cation transporter 2/Solute carrier family 22 member 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073662] [GtoPdb: 1020] [UniProtKB: O70577]
ChEMBL	TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes	F	5.55	pIC50	2800	nM	IC50	Biochem Biophys Res Commun (2002) 296: 644-650 [PMID:12176030]
Organic cation transporter 2/Solute carrier family 22 member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes	F	4.26	pKi	55000	nM	Ki	Am J Physiol Renal Physiol (2001) 281: F454-F468 [PMID:11502595]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake (in the absence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cells	F	4.42	pIC50	38000	nM	IC50	J Pharmacol Exp Ther (2002) 303: 959-968 [PMID:12438515]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cells	F	4.89	pIC50	13000	nM	IC50	J Pharmacol Exp Ther (2002) 303: 959-968 [PMID:12438515]
Solute carrier organic anion transporter family member 1A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781859] [UniProtKB: P46720]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing LLC-PK1 cells	F	4.12	pKi	76700	nM	Ki	Pharm Res (2002) 19: 147-153 [PMID:11883641]
Solute carrier organic anion transporter family member 1A4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781860] [UniProtKB: O35913]
ChEMBL	TP_TRANSPORTER: inhibition of Digoxin uptake in Oatp2-expressing LLC-PK1 cells	F	5.42	pKi	3810	nM	Ki	Pharm Res (2002) 19: 147-153 [PMID:11883641]
Kv2.2 in Human [GtoPdb: 547] [UniProtKB: Q92953]
GtoPdb	-	-	4.9	pIC50	-	-	-	Am J Physiol (1998) 274: G901-11 [PMID:9612272]
Plasma membrane monoamine transporter in Human [GtoPdb: 1120] [UniProtKB: Q7RTT9]
GtoPdb	-	-	4.57	pKi	26900	nM	Ki	Mol Pharmacol (2005) 68: 1397-407 [PMID:16099839]; Clin Pharmacol Ther (2016) 100: 489-499 [PMID:27506881]
Plasmodium falciparum purine nucleoside phosphorylase in Plasmodium falciparum [GtoPdb: 3077]
GtoPdb	-	-	6.86	pKi	138	nM	Ki	Sci Transl Med (2019) 11: [PMID:30602534]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]