[3H](+)-cis-diltiazem [Ligand Id: 2512] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL603584
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  • Cav1.1 in Rabbit [GtoPdb: 528]
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  • Cav1.2 in Rat [GtoPdb: 529] [UniProtKB: P22002]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG B 4.76 pIC50 17378.01 nM IC50 Eur. J. Med. Chem. (2011) 46: 618-630 [PMID:21185626]
Cav1.1 in Rabbit [GtoPdb: 528]
GtoPdb - - 7.4 pKd - - - J Biol Chem (1993) 268: 18580-5 [PMID:8395510];
J Pharmacol Exp Ther (1997) 281: 173-9 [PMID:9103495]
Cav1.2 in Rat [GtoPdb: 529] [UniProtKB: P22002]
GtoPdb - - 7.2 pKd - - - J Pharmacol Exp Ther (1990) 255: 600-7 [PMID:2147036]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]