ziconotide [Ligand Id: 2536] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4594214 (.omega.-conotoxin m viia, SNX-111, Ziconotide) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cav2.2/Voltage-gated N-type calcium channel alpha-1B subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4478] [GtoPdb: 533] [UniProtKB: Q00975] | ||||||||
| GtoPdb | - | - | 1 | pIC50 | - | - | - | J Neurosci (2002) 22: 82-92 [PMID:11756491] |
| ChEMBL | In vitro antagonism of N-type calcium channels expressed in PC12 cells was determined as the increase in intracellular calcium influx | F | 6.22 | pIC50 | 600 | nM | IC50 | J Med Chem (2004) 47: 6070-6081 [PMID:15537361] |
| ChEMBL | In vitro antagonism of N-type calcium channels expressed in PC12 cells was determined as the increase in intracellular calcium influx in the presence of 10 uM nifedipine | F | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2004) 47: 6070-6081 [PMID:15537361] |
| Cav2.2 in Rat [GtoPdb: 533] [UniProtKB: Q02294] | ||||||||
| GtoPdb | - | - | 10.3 | pIC50 | - | - | - |
J Biol Chem (2000) 275: 35335-44 [PMID:10938268]; Biochem Pharmacol (2006) 72: 770-82 [PMID:16844100] |
| Cav2.1 in Rat [GtoPdb: 532] [UniProtKB: P54282] | ||||||||
| GtoPdb | - | - | 6.3 | pIC50 | - | - | - | J Biol Chem (2000) 275: 35335-44 [PMID:10938268] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
