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ChEMBL ligand: CHEMBL4594214 (.omega.-conotoxin m viia, Prialt, SNX-111, Ziconotide) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Cav2.2/Voltage-gated N-type calcium channel alpha-1B subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4478] [GtoPdb: 533] [UniProtKB: Q00975] | ||||||||
GtoPdb | - | - | 1 | pIC50 | - | - | - | J Neurosci (2002) 22: 82-92 [PMID:11756491] |
ChEMBL | In vitro antagonism of N-type calcium channels expressed in PC12 cells was determined as the increase in intracellular calcium influx | F | 6.22 | pIC50 | 600 | nM | IC50 | J Med Chem (2004) 47: 6070-6081 [PMID:15537361] |
ChEMBL | In vitro antagonism of N-type calcium channels expressed in PC12 cells was determined as the increase in intracellular calcium influx in the presence of 10 uM nifedipine | F | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2004) 47: 6070-6081 [PMID:15537361] |
Cav2.2 in Rat [GtoPdb: 533] [UniProtKB: Q02294] | ||||||||
GtoPdb | - | - | 10.3 | pIC50 | - | - | - |
J Biol Chem (2000) 275: 35335-44 [PMID:10938268]; Biochem Pharmacol (2006) 72: 770-82 [PMID:16844100] |
Cav2.1 in Rat [GtoPdb: 532] [UniProtKB: P54282] | ||||||||
GtoPdb | - | - | 6.3 | pIC50 | - | - | - | J Biol Chem (2000) 275: 35335-44 [PMID:10938268] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]