tropisetron [Ligand Id: 260] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL56564 (ICS-205-930, Navoban, Tropisetron)
  • nicotinic acetylcholine receptor α1 subunit/nicotinic acetylcholine receptor γ subunit/nicotinic acetylcholine receptor β1 subunit/nicotinic acetylcholine receptor δ subunit/Acetylcholine receptor; alpha1/beta1/delta/gamma in Human [ChEMBL: CHEMBL1907588] [GtoPdb: 462475471476] [UniProtKB: P02708P07510P11230Q07001]
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  • D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
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  • M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
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  • nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α3 subunit/Neuronal acetylcholine receptor; alpha3/beta4 in Human [ChEMBL: CHEMBL1907594] [GtoPdb: 474464] [UniProtKB: P30926P32297]
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  • nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human [ChEMBL: CHEMBL1907589] [GtoPdb: 472465] [UniProtKB: P17787P43681]
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  • nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544]
  • nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Mouse [ChEMBL: CHEMBL3365] [GtoPdb: 468] [UniProtKB: P49582]
  • nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Rat [ChEMBL: CHEMBL4980] [GtoPdb: 468] [UniProtKB: Q05941]
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  • nicotinic acetylcholine receptor α3 subunit/Neuronal acetylcholine receptor subunit alpha-3 in Human [ChEMBL: CHEMBL3068] [GtoPdb: 464] [UniProtKB: P32297]
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
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  • 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
  • Serotonin 3a (5-HT3a) receptor in Guinea pig [ChEMBL: CHEMBL3666] [UniProtKB: O70212]
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  • 5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
  • 5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Mouse [ChEMBL: CHEMBL2183] [GtoPdb: 9] [UniProtKB: P97288]
  • 5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Rat [ChEMBL: CHEMBL4317] [GtoPdb: 9] [UniProtKB: Q62758]
  • Serotonin 4 (5-HT4) receptor in Guinea pig [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
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  • SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
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  • 5-HT3A in Human [GtoPdb: 379]
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  • glycine receptor α1 subunit in Human [GtoPdb: 423] [UniProtKB: P23415]
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  • glycine receptor α2 subunit in Human [GtoPdb: 424] [UniProtKB: P23416]
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  • glycine receptor β subunit in Human [GtoPdb: 427] [UniProtKB: P48167]
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  • Glycine Receptor (All subtypes) in Human [GtoPdb: 428]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
nicotinic acetylcholine receptor α1 subunit/nicotinic acetylcholine receptor γ subunit/nicotinic acetylcholine receptor β1 subunit/nicotinic acetylcholine receptor δ subunit/Acetylcholine receptor; alpha1/beta1/delta/gamma in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907588] [GtoPdb: 462475471476] [UniProtKB: P02708P07510P11230Q07001]
ChEMBL In vitro Binding affinity towards alpha-1-beta-1-gamma-delta nAChR was determined B 4.57 pKi 27000 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 319-321 [PMID:11212100]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL Binding affinity towards Dopamine receptor D2 in rat was evaluated B 6 pIC50 >1000 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 189-192 [PMID:11755351]
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
ChEMBL DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) B 5.61 pKi 2479 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) B 5.46 pIC50 3450 nM IC50 DrugMatrix in vitro pharmacology data
nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α3 subunit/Neuronal acetylcholine receptor; alpha3/beta4 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907594] [GtoPdb: 474464] [UniProtKB: P30926P32297]
ChEMBL Antagonism of ACh-evoked responses at human Nicotinic acetylcholine receptor alpha3-beta4 expressed in xenopus oocytes F 5.74 pIC50 1800 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 1849-1853 [PMID:15050614]
nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907589] [GtoPdb: 472465] [UniProtKB: P17787P43681]
ChEMBL In vitro Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 was determined B 4.26 pKi 55000 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 319-321 [PMID:11212100]
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544]
ChEMBL Inhibition constant against nicotinic acetylcholine receptor alpha7 B 8.16 pKi 6.9 nM Ki J. Med. Chem. (2005) 48: 6523-6543 [PMID:16220969]
ChEMBL Binding affinity to alpha7 nAChR B 8.16 pKi 6.9 nM Ki J. Med. Chem. (2011) 54: 7943-7961 [PMID:21919481]
ChEMBL Effective concentration that causes inhibition of alpha-7 nAChR, was determined. Values are expressed as EC50 +/- SEM. F 5.89 pEC50 1300 nM EC50 Bioorg. Med. Chem. Lett. (2001) 11: 319-321 [PMID:11212100]
ChEMBL Agonist activity at alpha7 nAChR F 5.89 pEC50 1300 nM EC50 J. Med. Chem. (2011) 54: 7943-7961 [PMID:21919481]
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3365] [GtoPdb: 468] [UniProtKB: P49582]
ChEMBL In vitro Binding affinity towards alpha-7 nAChR was determined B 8.16 pKi 6.9 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 319-321 [PMID:11212100]
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4980] [GtoPdb: 468] [UniProtKB: Q05941]
ChEMBL Partial agonist activity at rat alpha-7 nicotinic acetylcholine receptor expressed in Xenopus oocytes assessed as induction of currents B 5.89 pEC50 1300 nM EC50 Bioorg. Med. Chem. Lett. (2015) 25: 3184-3188 [PMID:26087938]
ChEMBL Activation responses to that evoked by ACh at human Nicotinic acetylcholine receptor alpha-7 expressed in xenopus oocytes B 8 pEC50 10 nM EC50 Bioorg. Med. Chem. Lett. (2004) 14: 1849-1853 [PMID:15050614]
nicotinic acetylcholine receptor α3 subunit/Neuronal acetylcholine receptor subunit alpha-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3068] [GtoPdb: 464] [UniProtKB: P32297]
ChEMBL In vitro Binding affinity towards alpha-3 (PC12) nAChR was determined B 4.8 pKi 16000 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 319-321 [PMID:11212100]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Inhibition constant against 5-hydroxytryptamine 1A receptor B 8.28 pKi 5.3 nM Ki J. Med. Chem. (2005) 48: 6523-6543 [PMID:16220969]
5-HT3E/5-HT3B/5-HT3A/5-HT3D/5-HT3C/Serotonin 3 (5-HT3) receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094132] [GtoPdb: 377374373376375] [UniProtKB: A5X5Y0O95264P46098Q70Z44Q8WXA8]
ChEMBL Binding affinity to 5-hydroxytryptamine 3 receptor entirely in guinea pig ileum B 7.9 pKd 12.59 nM Kd J. Med. Chem. (1990) 33: 1594-1600 [PMID:2342053]
ChEMBL Antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor of isolated guinea pig ileum (GPI) F 7.9 pKd 12.59 nM Kd Bioorg. Med. Chem. Lett. (1992) 2: 461-466
ChEMBL Binding affinity to 5-hydroxytryptamine 3 receptor of neuronal in the afferent rabbit vagus B 10.2 pKd 0.06 nM Kd J. Med. Chem. (1990) 33: 1594-1600 [PMID:2342053]
ChEMBL Antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor in isolated rabbit vagus nerve (RVN) F 10.2 pKd 0.06 nM Kd Bioorg. Med. Chem. Lett. (1992) 2: 461-466
ChEMBL Evaluated for the antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor in isolated perfused rabbit heart (RH) F 10.6 pKd 0.03 nM Kd Bioorg. Med. Chem. Lett. (1992) 2: 461-466
ChEMBL Binding affinity of compound towards 5-hydroxytryptamine 3 receptor using [3H]-BRL-43694 (1 nM) ligand in NG cells 108-15 was determined B 7.48 pKi 33 nM Ki J. Med. Chem. (1997) 40: 952-960 [PMID:9083484]
ChEMBL In vitro Binding affinity towards 5-hydroxytryptamine 3 receptor was determined B 8.28 pKi 5.3 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 319-321 [PMID:11212100]
5-HT3A/5-HT3B/Serotonin 3 (5-HT3) receptor in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094116] [GtoPdb: 373374] [UniProtKB: P35563Q9JJ16]
ChEMBL Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement [3H]GR-65630 in rat cerebral cortex B 8.49 pKi 3.2 nM Ki J. Med. Chem. (1998) 41: 311-317 [PMID:9464362]
ChEMBL Binding affinity to 5-hydroxytryptamine 3 receptor using [3H]GR-65630 as radioligand in rat cortex B 8.5 pKi 3.16 nM Ki J. Med. Chem. (1990) 33: 1594-1600 [PMID:2342053]
ChEMBL In vitro displacement of [3H]ICS-205-930 from 5-hydroxytryptamine 3 receptor in cultured NG-108-15 rat glioma cells B 8.57 pKi 2.7 nM Ki J. Med. Chem. (1990) 33: 13-16 [PMID:2296012]
ChEMBL Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazine B 8.7 pKi 2 nM Ki J. Med. Chem. (1993) 36: 2645-2657 [PMID:8410977]
ChEMBL Concentration that inhibits the binding of radioligand, [3H]-ICS 205930, to 5-hydroxytryptamine 3 receptor from rat cortex B 8.77 pKi 1.71 nM Ki J. Med. Chem. (1990) 33: 2101-2108 [PMID:1695682]
ChEMBL In vitro by displacement of [3H]LY-278584 from 5-hydroxytryptamine 3 receptor on rat entorhinal cortex B 8.8 pKi 1.58 nM Ki J. Med. Chem. (1997) 40: 586-593 [PMID:9046349]
ChEMBL In vitro affinity for 5-hydroxytryptamine 3 (5-HT3) receptor by displacement of [3H]BRL-43694 from rat entorhinal cortex B 8.8 pKi 1.57 nM Ki J. Med. Chem. (1997) 40: 3369-3380 [PMID:9341912]
ChEMBL Binding affinity towards rat 5-hydroxytryptamine 3 receptor was evaluated B 8.81 pKi 1.55 nM Ki Bioorg. Med. Chem. Lett. (2002) 12: 189-192 [PMID:11755351]
ChEMBL pKi value for inhibition of [3H]LY-278584 binding to 5-hydroxytryptamine 3 receptor B 8.89 pKi 1.29 nM Ki J. Med. Chem. (1990) 33: 3176-3181 [PMID:2258903]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 3 receptor in rat cortical membranes using [3H]- 1-Methyl-1H-indazole-3-carboxylic acid (8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide as a radioligand B 8.89 pKi 1.28 nM Ki J. Med. Chem. (1990) 33: 3176-3181 [PMID:2258903]
ChEMBL In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptor B 8.89 pKi 1.28 nM Ki Bioorg. Med. Chem. Lett. (1996) 6: 1195-1198
ChEMBL Binding affinity to 5-hydroxytryptamine 3 receptor using [3H]quipazine as radioligand in rat cortex B 9.22 pKi 0.6 nM Ki J. Med. Chem. (1990) 33: 1594-1600 [PMID:2342053]
ChEMBL Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 3 receptor B 8.51 pIC50 3.1 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 695-698
ChEMBL Binding affinity was evaluated in vitro by displacement of [3H]zacopride radioligand from 5-hydroxytryptamine 3 receptor B 8.64 pIC50 2.3 nM IC50 Bioorg. Med. Chem. Lett. (1992) 2: 245-248
ChEMBL Inhibition of 5-HT (1 ug/mL) induced depolarization in rat vagus nerve (5-hydroxytryptamine 3 receptor antagonism) F 8.85 pIC50 1.4 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 695-698
ChEMBL Compound was evaluated for the displacement of [3H]Q-ICS-205-930 from 5-HT3 recognition sites in rat brain membranes B 8.9 pIC50 1.26 nM IC50 J. Med. Chem. (1992) 35: 1019-1031 [PMID:1552497]
5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
ChEMBL Inhibition of 5HT3 receptor B 8.28 pKi 5.3 nM Ki J. Med. Chem. (2011) 54: 7943-7961 [PMID:21919481]
ChEMBL Binding affinity at 5HT3 receptor B 8.55 pKi 2.82 nM Ki Bioorg. Med. Chem. (2009) 17: 2607-2622 [PMID:19261477]
ChEMBL Binding affinity towards 5-hydroxytryptamine 3 receptor by displacement of [3H]2 in Neuroblastoma-Glioma NG-108-15 cells B 8.57 pKi 2.7 nM Ki J. Med. Chem. (1990) 33: 2715-2720 [PMID:2213824]
ChEMBL In vitro binding affinity for the 5-hydroxytryptamine 3 receptor was determined with NG-108-15 mouse neuroblastoma-glioma cells B 8.57 pKi 2.7 nM Ki J. Med. Chem. (1990) 33: 2721-2725 [PMID:2145434]
Serotonin 3a (5-HT3a) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3666] [UniProtKB: O70212]
ChEMBL Antagonist activity at 5HT3 receptor in spontaneously beating guinea pig right atrium assessed as inhibition of serotonin-induced maximum response by competitive binding assay B 7.52 pKd 30.2 nM Kd J. Med. Chem. (2009) 52: 3548-3562 [PMID:19425598]
5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
ChEMBL Binding affinity at 5HT4 receptor B 6.7 pKi 199.53 nM Ki Bioorg. Med. Chem. (2009) 17: 2607-2622 [PMID:19261477]
GtoPdb - - 7.1 pKi - - - J Neurochem (1997) 69: 1810-9 [PMID:9349523];
Naunyn Schmiedebergs Arch Pharmacol (2001) 363: 146-60 [PMID:11218067]
5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2183] [GtoPdb: 9] [UniProtKB: P97288]
ChEMBL Tested for ability to stimulate 5-hydroxytryptamine 4 receptors in mouse Coliculi neurons B 6.2 pKi 6.2 nM Log Ki J. Med. Chem. (2003) 46: 319-344 [PMID:12540230]
GtoPdb - - 7.1 pKi - - - FEBS Lett (1996) 398: 19-25 [PMID:8946946]
5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4317] [GtoPdb: 9] [UniProtKB: Q62758]
GtoPdb - - 6.8 pKi - - - Eur J Pharmacol (1996) 304: 231-5 [PMID:8813606]
ChEMBL Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptor B 7.2 pKi 63 nM Ki Bioorg. Med. Chem. Lett. (1996) 6: 1195-1198
Serotonin 4 (5-HT4) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
ChEMBL Evaluated for the antagonistic activity against Serotonin 5-hydroxytryptamine 4 receptor in non-electrically stimulated guinea-pig ileum. F 5.7 pKd 1995.26 nM Kd Bioorg. Med. Chem. Lett. (1992) 2: 461-466
ChEMBL Binding affinity towards 5-hydroxytryptamine 4 receptor in striatum membranes of guinea-pig brain was evaluated B 6.9 pKi 125.1 nM Ki Bioorg. Med. Chem. Lett. (2002) 12: 189-192 [PMID:11755351]
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) B 7.27 pKi 54 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL Inhibition of 5-HT-evoked 5-HT4 receptor-mediated contractions in the guinea pig distal colon longitudinal muscle myenteric plexus (LMMP) F 5.5 pIC50 3162.28 nM IC50 J. Med. Chem. (1993) 36: 4121-4123 [PMID:8258837]
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) B 6.49 pIC50 324 nM IC50 DrugMatrix in vitro pharmacology data
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) B 6.59 pKi 259 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) B 6.31 pIC50 488 nM IC50 DrugMatrix in vitro pharmacology data
5-HT3A in Human [GtoPdb: 379]
GtoPdb - - 8.8 pKi 1.5 nM Ki Mol Pharmacol (1995) 48: 407-16 [PMID:7565620];
Mol Pharmacol (1998) 53: 202-12 [PMID:9463477]
glycine receptor α1 subunit in Human [GtoPdb: 423] [UniProtKB: P23415]
GtoPdb - - 4.1 pKi 84000 nM Ki
glycine receptor α2 subunit in Human [GtoPdb: 424] [UniProtKB: P23416]
GtoPdb - - 4.9 pKi 13000 nM Ki
glycine receptor β subunit in Human [GtoPdb: 427] [UniProtKB: P48167]
GtoPdb - - 5.3 pKi 5400 nM Ki
Glycine Receptor (All subtypes) in Human [GtoPdb: 428]
GtoPdb - - 4.1 pIC50 - - - J Neurochem (1999) 73: 802-6 [PMID:10428078];
J Neurochem (2007) 100: 758-69 [PMID:17181559]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]