(S)-N-[1-(3-morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamide [Ligand Id: 2600] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL317935 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
| ChEMBL | Inhibition of recombinant human Cytochrome P450 19A1 | B | 4.89 | pIC50 | 13000 | nM | IC50 | J Med Chem (2003) 46: 3778-3781 [PMID:12930139] |
| Kv7.3/Kv7.2/Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2221348] [GtoPdb: 562, 561] [UniProtKB: O43525, O43526] | ||||||||
| GtoPdb | - | - | 5.5 | pEC50 | - | - | - |
J Med Chem (2003) 46: 3197-200 [PMID:12852750]; Neuropharmacology (2006) 51: 1068-77 [PMID:16904708] |
| ChEMBL | Effect on resting membrane potential in SH-SY5Y human neuroblastoma cells expressing native KCNQ channels | F | 6.16 | pEC50 | 690 | nM | EC50 | J Med Chem (2003) 46: 3197-3200 [PMID:12852750] |
| Kv7.2/Voltage-gated potassium channel subunit Kv7.2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2476] [GtoPdb: 561] [UniProtKB: O43526] | ||||||||
| GtoPdb | - | - | 5.5 | pEC50 | - | - | - |
J Med Chem (2003) 46: 3197-200 [PMID:12852750]; Neuropharmacology (2006) 51: 1068-77 [PMID:16904708] |
| ChEMBL | Effective concentration against Potassium voltage gated channel KQT-like subfamily, member 2 expressed in HEK 293 cells | B | 5.52 | pEC50 | 3000 | nM | EC50 | J Med Chem (2003) 46: 3778-3781 [PMID:12930139] |
| ChEMBL | Effective concentration against Potassium voltage gated channel, KQT-like subfamily, member 2 expressed in SH-SY5Y human neuroblastoma cells | B | 6.16 | pEC50 | 690 | nM | EC50 | J Med Chem (2003) 46: 3778-3781 [PMID:12930139] |
| Kv7.2/Voltage-gated potassium channel subunit Kv7.2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2985] [GtoPdb: 561] [UniProtKB: Q9Z351] | ||||||||
| ChEMBL | Induced current in Xenopus laevis oocytes expressing cloned mKCNQ2 channels | F | 5.22 | pEC50 | 6000 | nM | EC50 | J Med Chem (2003) 46: 3197-3200 [PMID:12852750] |
| ChEMBL | Whole-cell patch-clamp on recombinant mouse KCNQ2 channels expressed in HEK 293 cells at -40 mV | F | 5.48 | pEC50 | 3280 | nM | EC50 | Bioorg Med Chem Lett (2004) 14: 1991-1995 [PMID:15050644] |
| ChEMBL | Effect on outward potassium currents in whole-cell patch clamp assay of HEK 293 cells expressing cloned mouse KCNQ2 channel at -40 mV | F | 5.49 | pEC50 | 3200 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 363-366 [PMID:15603955] |
| ChEMBL | Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assay | B | 5.49 | pEC50 | 3200 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 6188-6191 [PMID:24070783] |
| Kv7.4 in Human [GtoPdb: 563] [UniProtKB: P56696] | ||||||||
| GtoPdb | - | - | 5 | pIC50 | 10400 | nM | IC50 | Neuropharmacology (2006) 51: 1068-77 [PMID:16904708] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
