tetrodotoxin [Ligand Id: 2616] activity data from GtoPdb

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  • Nav1.1 in Rat [GtoPdb: 578] [UniProtKB: P04774]
  • This target only has 0 pki data point
1 _lig_chart_1 Nav1.1 Rat
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  • Nav1.2 in Rat [GtoPdb: 579] [UniProtKB: P04775]
  • This target only has 0 pki data point
2 _lig_chart_2 Nav1.2 Rat
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  • Nav1.3 in Human [GtoPdb: 580] [UniProtKB: Q9NY46]
  • This target only has 0 pki data point
3 _lig_chart_3 Nav1.3 Human
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  • Nav1.4 in Human [GtoPdb: 581] [UniProtKB: P35499]
  • Nav1.4 in Rat [GtoPdb: 581] [UniProtKB: P15390]
  • This target only has 0 pki data point
4 _lig_chart_4 Nav1.4 HumanRat
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  • Nav1.5 in Rat [GtoPdb: 582] [UniProtKB: P15389]
  • This target only has 0 pki data point
5 _lig_chart_5 Nav1.5 Rat
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  • Nav1.6 in Mouse [GtoPdb: 583] [UniProtKB: Q9WTU3]
  • Nav1.6 in Rat [GtoPdb: 583] [UniProtKB: O88420]
  • This target only has 0 pki data point
6 _lig_chart_6 Nav1.6 MouseRat
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  • Nav1.7 in Human [GtoPdb: 584] [UniProtKB: Q15858]
  • Nav1.7 in Rat [GtoPdb: 584] [UniProtKB: O08562]
  • This target only has 0 pki data point
7 _lig_chart_7 Nav1.7 HumanRat
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  • Nav1.8 in Rat [GtoPdb: 585] [UniProtKB: Q62968]
  • This target only has 0 pki data point
8 _lig_chart_8 Nav1.8 Rat
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  • Nav1.9 in Rat [GtoPdb: 586] [UniProtKB: O88457]
  • This target only has 0 pki data point
9 _lig_chart_9 Nav1.9 Rat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Nav1.1 in Rat [GtoPdb: 578] [UniProtKB: P04774]
GtoPdb - - 8 pKd - - - J. Neurosci. (1998) 18: 811-20 [PMID:9437003]
Nav1.2 in Rat [GtoPdb: 579] [UniProtKB: P04775]
GtoPdb - - 8 pIC50 11.2 nM IC50 Nature (2005) 434: 763-7 [PMID:15815630]
Nav1.3 in Human [GtoPdb: 580] [UniProtKB: Q9NY46]
GtoPdb - - 8.4 pIC50 4 nM IC50 Eur. J. Neurosci. (2000) 12: 4281-9 [PMID:11122339]
Nav1.4 in Human [GtoPdb: 581] [UniProtKB: P35499]
GtoPdb - - 7.6 pIC50 25 nM IC50 Pflugers Arch. (1994) 427: 136-42 [PMID:8058462]
Nav1.4 in Rat [GtoPdb: 581] [UniProtKB: P15390]
GtoPdb - - 8.3 pIC50 - - - Neuron (1989) 3: 33-49 [PMID:2559760]
Nav1.5 in Rat [GtoPdb: 582] [UniProtKB: P15389]
GtoPdb - - 5.8 pKd 1520 nM Kd Am. J. Physiol. (1996) 270: C1522-31 [PMID:8967455];
FEBS Lett. (1990) 275: 195-200 [PMID:2175715]
Nav1.6 in Mouse [GtoPdb: 583] [UniProtKB: Q9WTU3]
GtoPdb - - 8.2 pIC50 - - - J. Neurosci. (1998) 18: 6093-102 [PMID:9698304]
Nav1.6 in Rat [GtoPdb: 583] [UniProtKB: O88420]
GtoPdb - - 9 pIC50 1 nM IC50 J. Neurochem. (1998) 70: 2262-72 [PMID:9603190]
Nav1.7 in Human [GtoPdb: 584] [UniProtKB: Q15858]
GtoPdb - - 7.6 pIC50 24.5 nM IC50 EMBO J. (1995) 14: 1084-90 [PMID:7720699]
Nav1.7 in Rat [GtoPdb: 584] [UniProtKB: O08562]
GtoPdb - - 8.4 pIC50 - - - J. Biol. Chem. (1997) 272: 14805-9 [PMID:9169448]
Nav1.8 in Rat [GtoPdb: 585] [UniProtKB: Q62968]
GtoPdb - - 4.2 pIC50 59600 nM IC50 Nature (1996) 379: 257-62 [PMID:8538791]
Nav1.9 in Rat [GtoPdb: 586] [UniProtKB: O88457]
GtoPdb - - 4.4 pIC50 39000 nM IC50 J. Neurosci. (1999) 19: RC43 [PMID:10594087]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.