ChEMBL ligand: CHEMBL1624 (Levothyroxine, NSC-36397)
Farnesoid X receptor/Bile acid receptor FXR in Human [ChEMBL: CHEMBL2047] [GtoPdb: 603] [UniProtKB: Q96RI1] This target only has 0 pki data point 0 1 CHEMBL1624_lig_chart_1 Bile acid receptor FXR Human There should be some charts here, you may need to enable JavaScript!
Malate dehydrogenase, mitochondrial in Human [ChEMBL: CHEMBL5917] [UniProtKB: P40926] This target only has 0 pki data point 0 2 CHEMBL1624_lig_chart_2 Malate dehydrogenase, mitochondrial Human There should be some charts here, you may need to enable JavaScript!
Proliferating cell nuclear antigen in Human [ChEMBL: CHEMBL2346488] [UniProtKB: P12004] This target only has 0 pki data point 0 3 CHEMBL1624_lig_chart_3 Proliferating cell nuclear antigen Human There should be some charts here, you may need to enable JavaScript!
OATP4C1/Solute carrier organic anion transporter family member 4C1 in Human [ChEMBL: CHEMBL2073690] [GtoPdb: 1227] [UniProtKB: Q6ZQN7] This target only has 0 pki data point 0 4 CHEMBL1624_lig_chart_4 Solute carrier organic anion transporter family member 4C1 Human There should be some charts here, you may need to enable JavaScript!
transthyretin/Transthyretin in Human [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766] This target only has 0 pki data point 0 5 CHEMBL1624_lig_chart_5 Transthyretin Human There should be some charts here, you may need to enable JavaScript!
Thyroid hormone receptor-β in Human [GtoPdb: 589] [UniProtKB: P10828] This target only has 0 pki data point 0 6 CHEMBL1624_lig_chart_6 Thyroid hormone receptor-β Human There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Farnesoid X receptor/Bile acid receptor FXR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2047] [GtoPdb: 603] [UniProtKB: Q96RI1]
ChEMBL	Antagonist activity at human GTS-tagged FXR after 20 mins by TR-FRET assay	B	5.1	pIC50	7860	nM	IC50	Bioorg. Med. Chem. (2013) 21: 4266-4278 [PMID:23688559]
Malate dehydrogenase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5917] [UniProtKB: P40926]
ChEMBL	Inhibition of MDH2 (unknown origin)	B	4.36	pIC50	43600	nM	IC50	J Med Chem (2017) 60: 8631-8646 [PMID:28991459]
Proliferating cell nuclear antigen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2346488] [UniProtKB: P12004]
ChEMBL	Inhibition of human recombinant PCNA interaction with PIP box protein N-5-carboxyfluorescein-SAVLQKKITDYFHPKK after 30 mins by fluorescence polarization assay	B	4.3	pIC50	>50000	nM	IC50	Bioorg. Med. Chem. (2013) 21: 1972-1977 [PMID:23395113]
OATP4C1/Solute carrier organic anion transporter family member 4C1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073690] [GtoPdb: 1227] [UniProtKB: Q6ZQN7]
ChEMBL	TP_TRANSPORTER: inhibition of Triiodothyronine uptake in OATP4C1-expressing MDCK cells	F	5.1	pIC50	8000	nM	IC50	Proc. Natl. Acad. Sci. U.S.A. (2004) 101: 3569-3574 [PMID:14993604]
transthyretin/Transthyretin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766]
ChEMBL	Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assay	B	4.98	pIC50	10500	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 5270-5273 [PMID:19651509]
ChEMBL	Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuring turbidity preincubated for 30 mins followed by lowering pH from 7.2 to 4.4 measured after 72 hrs by microplate spectrophotometric method	B	5.66	pIC50	2200	nM	IC50	Eur J Med Chem (2016) 121: 823-840 [PMID:27020050]
ChEMBL	Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuring turbidity preincubated for 30 mins followed by lowering pH from 7.2 to 4.4 measured after 72 hrs by microplate spectrophotometric method	B	5.66	pIC50	2187.76	nM	IC50	Eur J Med Chem (2016) 121: 823-840 [PMID:27020050]
Thyroid hormone receptor-β in Human [GtoPdb: 589] [UniProtKB: P10828]
GtoPdb	-	-	8.52	pIC50	-	-	-	Mol Endocrinol (1990) 4: 227-34 [PMID:2158622]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]