Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL1624 (Levothyroxine, NSC-36397) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Farnesoid X receptor/Bile acid receptor FXR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2047] [GtoPdb: 603] [UniProtKB: Q96RI1] | ||||||||
ChEMBL | Antagonist activity at human GTS-tagged FXR after 20 mins by TR-FRET assay | B | 5.1 | pIC50 | 7860 | nM | IC50 | Bioorg. Med. Chem. (2013) 21: 4266-4278 [PMID:23688559] |
Malate dehydrogenase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5917] [UniProtKB: P40926] | ||||||||
ChEMBL | Inhibition of MDH2 (unknown origin) | B | 4.36 | pIC50 | 43600 | nM | IC50 | J Med Chem (2017) 60: 8631-8646 [PMID:28991459] |
Proliferating cell nuclear antigen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2346488] [UniProtKB: P12004] | ||||||||
ChEMBL | Inhibition of human recombinant PCNA interaction with PIP box protein N-5-carboxyfluorescein-SAVLQKKITDYFHPKK after 30 mins by fluorescence polarization assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg. Med. Chem. (2013) 21: 1972-1977 [PMID:23395113] |
OATP4C1/Solute carrier organic anion transporter family member 4C1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073690] [GtoPdb: 1227] [UniProtKB: Q6ZQN7] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of Triiodothyronine uptake in OATP4C1-expressing MDCK cells | F | 5.1 | pIC50 | 8000 | nM | IC50 | Proc. Natl. Acad. Sci. U.S.A. (2004) 101: 3569-3574 [PMID:14993604] |
transthyretin/Transthyretin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766] | ||||||||
ChEMBL | Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assay | B | 4.98 | pIC50 | 10500 | nM | IC50 | Bioorg. Med. Chem. Lett. (2009) 19: 5270-5273 [PMID:19651509] |
ChEMBL | Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuring turbidity preincubated for 30 mins followed by lowering pH from 7.2 to 4.4 measured after 72 hrs by microplate spectrophotometric method | B | 5.66 | pIC50 | 2200 | nM | IC50 | Eur J Med Chem (2016) 121: 823-840 [PMID:27020050] |
ChEMBL | Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuring turbidity preincubated for 30 mins followed by lowering pH from 7.2 to 4.4 measured after 72 hrs by microplate spectrophotometric method | B | 5.66 | pIC50 | 2187.76 | nM | IC50 | Eur J Med Chem (2016) 121: 823-840 [PMID:27020050] |
Thyroid hormone receptor-β in Human [GtoPdb: 589] [UniProtKB: P10828] | ||||||||
GtoPdb | - | - | 8.52 | pIC50 | - | - | - | Mol Endocrinol (1990) 4: 227-34 [PMID:2158622] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]