rT3 [Ligand Id: 2636] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1312 (Reverse triiodothyronine)
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  • Thyroid hormone receptor-β in Human [GtoPdb: 589] [UniProtKB: P10828]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GAT1/GABA transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4054] [GtoPdb: 929] [UniProtKB: P23978]
ChEMBL Inhibition of rat GAT1 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake by liquid scintillation counting B 4.89 pIC50 13000 nM IC50 J Med Chem (2015) 58: 2149-2158 [PMID:25679268]
Thyroid hormone receptor-β in Human [GtoPdb: 589] [UniProtKB: P10828]
GtoPdb - - 7.34 pKd - - - Mol Endocrinol (1990) 4: 227-34 [PMID:2158622]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]