rT3 [Ligand Id: 2636] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1312 (Reverse triiodothyronine)
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  • Thyroid hormone receptor-β in Human [GtoPdb: 589] [UniProtKB: P10828]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GAT1/GABA transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4054] [GtoPdb: 929] [UniProtKB: P23978]
ChEMBL Inhibition of rat GAT1 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake by liquid scintillation counting B 4.89 pIC50 13000 nM IC50 J. Med. Chem. (2015) 58: 2149-2158 [PMID:25679268]
Thyroid hormone receptor-β in Human [GtoPdb: 589] [UniProtKB: P10828]
GtoPdb - - 7.34 pKd - - - Mol Endocrinol (1990) 4: 227-34 [PMID:2158622]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]