ChEMBL ligand: CHEMBL107400 (QRX-431, Sobetirome, GC-1)
Thyroid hormone receptor-α/Thyroid hormone receptor alpha in Human [ChEMBL: CHEMBL1860] [GtoPdb: 588] [UniProtKB: P10827] This target only has 1 pki data point 1 CHEMBL107400_lig_chart_1 Thyroid hormone receptor alpha Human There should be some charts here, you may need to enable JavaScript!
Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Human [ChEMBL: CHEMBL1947] [GtoPdb: 589] [UniProtKB: P10828] This target only has 1 pki data point 2 CHEMBL107400_lig_chart_2 Thyroid hormone receptor beta-1 Human There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Thyroid hormone receptor-α/Thyroid hormone receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1860] [GtoPdb: 588] [UniProtKB: P10827]
ChEMBL	Binding affinity to human TRalpha1	B	8.6	pKd	2.5	nM	Kd	J. Med. Chem. (2012) 55: 5649-5675 [PMID:22512468]
ChEMBL	Binding affinity against human Thyroid hormone receptor alpha-1 (hTRalpha1) using radiolabeled T3	B	8.74	pKd	1.8	nM	Kd	J. Med. Chem. (2002) 45: 3310-3320 [PMID:12109914]
ChEMBL	Binding affinity of compound was determined against Thyroid hormone receptor alpha1	B	9.18	pKd	0.66	nM	Kd	J. Med. Chem. (2003) 46: 3152-3161 [PMID:12825953]
GtoPdb	-	-	9.36	pKd	-	-	-	Mol. Endocrinol. (1990) 4: 227-34 [PMID:2158622]
ChEMBL	Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay	B	8.96	pKi	1.09	nM	Ki	J. Med. Chem. (2008) 51: 7075-7093 [PMID:18975928]
ChEMBL	Half-maximum activation of human Thyroid hormone receptor alpha-1 (hTRalpha1)	B	7.35	pEC50	45	nM	EC50	J. Med. Chem. (2002) 45: 3310-3320 [PMID:12109914]
ChEMBL	Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 mins assessed as biotin-GRIP1 peptide recruitment by HTRF assay	B	8.52	pEC50	3	nM	EC50	J. Med. Chem. (2014) 57: 3912-3923 [PMID:24712661]
Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1947] [GtoPdb: 589] [UniProtKB: P10828]
ChEMBL	Binding affinity to human TRbeta1	B	9.7	pKd	0.2	nM	Kd	J. Med. Chem. (2012) 55: 5649-5675 [PMID:22512468]
ChEMBL	Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3	B	10	pKd	0.1	nM	Kd	J. Med. Chem. (2002) 45: 3310-3320 [PMID:12109914]
ChEMBL	Binding affinity of compound was determined against thyroid hormone receptor beta 1	B	10	pKd	0.1	nM	Kd	J. Med. Chem. (2003) 46: 3152-3161 [PMID:12825953]
GtoPdb	-	-	10.17	pKd	-	-	-	Proc. Natl. Acad. Sci. U.S.A. (1977) 74: 3365-9 [PMID:269396]; Chem. Biol. (1998) 5: 299-306 [PMID:9653548]
ChEMBL	Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay	B	9.49	pKi	0.32	nM	Ki	J. Med. Chem. (2008) 51: 7075-7093 [PMID:18975928]
ChEMBL	Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 mins assessed as biotin-GRIP1 peptide recruitment by HTRF assay	B	7.74	pEC50	18	nM	EC50	J. Med. Chem. (2014) 57: 3912-3923 [PMID:24712661]
ChEMBL	Half-maximum activation of human Thyroid hormone receptor beta 1 (hTRbeta1)	B	8.15	pEC50	7	nM	EC50	J. Med. Chem. (2002) 45: 3310-3320 [PMID:12109914]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]