BMS493 [Ligand Id: 2641] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL472172 (BMS-204493)
  • Retinoic acid receptor-α/Retinoic acid receptor alpha in Human [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276]
  • This target only has 0 pki data point
  • 0
1 CHEMBL472172_lig_chart_1 Retinoic acid receptor alpha Human
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  • Retinoic acid receptor-β in Human [GtoPdb: 591] [UniProtKB: P10826]
  • This target only has 0 pki data point
  • 0
2 CHEMBL472172_lig_chart_2 Retinoic acid receptor-β Human
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  • Retinoic acid receptor-γ in Human [GtoPdb: 592] [UniProtKB: P13631]
  • This target only has 0 pki data point
  • 0
3 CHEMBL472172_lig_chart_3 Retinoic acid receptor-γ Human
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  • TLX in Human [GtoPdb: 615] [UniProtKB: Q9Y466]
  • This target only has 0 pki data point
  • 0
4 CHEMBL472172_lig_chart_4 TLX Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276]
ChEMBL Inverse agonist activity at RARalpha (unknown origin) B 6.94 pIC50 114 nM IC50 Bioorg. Med. Chem. (2014) 22: 1285-1302 [PMID:24457093]
GtoPdb - - 8.4 pIC50 - - - Nature (2002) 415: 187-92 [PMID:11805839]
Retinoic acid receptor-β in Human [GtoPdb: 591] [UniProtKB: P10826]
GtoPdb - - 8.54 pIC50 - - - Nature (2002) 415: 187-92 [PMID:11805839]
Retinoic acid receptor-γ in Human [GtoPdb: 592] [UniProtKB: P13631]
GtoPdb - - 7 pIC50 - - - Nature (2002) 415: 187-92 [PMID:11805839]
TLX in Human [GtoPdb: 615] [UniProtKB: Q9Y466]
GtoPdb Full-length TLX luciferase reporter system in HEK293 cells. - 7.27 pIC50 54 nM IC50 Cell Chem Biol (2020) 27: 1272-1284.e4 [PMID:32763139]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]