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ChEMBL ligand: CHEMBL472172 (BMS-204493) |
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CHEMBL472172_lig_chart_4
TLX
Human
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276] | ||||||||
ChEMBL | Inverse agonist activity at RARalpha (unknown origin) | B | 6.94 | pIC50 | 114 | nM | IC50 | Bioorg. Med. Chem. (2014) 22: 1285-1302 [PMID:24457093] |
GtoPdb | - | - | 8.4 | pIC50 | - | - | - | Nature (2002) 415: 187-92 [PMID:11805839] |
Retinoic acid receptor-β in Human [GtoPdb: 591] [UniProtKB: P10826] | ||||||||
GtoPdb | - | - | 8.54 | pIC50 | - | - | - | Nature (2002) 415: 187-92 [PMID:11805839] |
Retinoic acid receptor-γ in Human [GtoPdb: 592] [UniProtKB: P13631] | ||||||||
GtoPdb | - | - | 7 | pIC50 | - | - | - | Nature (2002) 415: 187-92 [PMID:11805839] |
TLX in Human [GtoPdb: 615] [UniProtKB: Q9Y466] | ||||||||
GtoPdb | Full-length TLX luciferase reporter system in HEK293 cells. | - | 7.27 | pIC50 | 54 | nM | IC50 | Cell Chem Biol (2020) 27: 1272-1284.e4 [PMID:32763139] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]