BMS493 [Ligand Id: 2641] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL472172 (BMS-204493) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276] | ||||||||
| ChEMBL | Inverse agonist activity at RARalpha (unknown origin) | B | 6.94 | pIC50 | 114 | nM | IC50 | Bioorg Med Chem (2014) 22: 1285-1302 [PMID:24457093] |
| GtoPdb | - | - | 8.4 | pIC50 | - | - | - | Nature (2002) 415: 187-92 [PMID:11805839] |
| Retinoic acid receptor-β in Human [GtoPdb: 591] [UniProtKB: P10826] | ||||||||
| GtoPdb | - | - | 8.54 | pIC50 | - | - | - | Nature (2002) 415: 187-92 [PMID:11805839] |
| Retinoic acid receptor-γ in Human [GtoPdb: 592] [UniProtKB: P13631] | ||||||||
| GtoPdb | - | - | 7 | pIC50 | - | - | - | Nature (2002) 415: 187-92 [PMID:11805839] |
| TLX in Human [GtoPdb: 615] [UniProtKB: Q9Y466] | ||||||||
| GtoPdb | Full-length TLX luciferase reporter system in HEK293 cells. | - | 7.27 | pIC50 | 54 | nM | IC50 | Cell Chem Biol (2020) 27: 1272-1284.e4 [PMID:32763139] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
