ChEMBL ligand: CHEMBL275311 (Ro-137410)
RAR-related orphan receptor-γ/Nuclear receptor ROR-gamma in Human [ChEMBL: CHEMBL1741186] [GtoPdb: 600] [UniProtKB: P51449] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276] There should be some charts here, you may need to enable JavaScript!
Retinoic acid receptor-β/Retinoic acid receptor beta in Human [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826] There should be some charts here, you may need to enable JavaScript!
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631] There should be some charts here, you may need to enable JavaScript!
Retinoid X receptor-α/Retinoid X receptor alpha in Human [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793] There should be some charts here, you may need to enable JavaScript!
Retinoid X receptor-β/Retinoid X receptor beta in Human [ChEMBL: CHEMBL1870] [GtoPdb: 611] [UniProtKB: P28702] There should be some charts here, you may need to enable JavaScript!
Retinoid X receptor-γ/Retinoid X receptor gamma in Human [ChEMBL: CHEMBL2004] [GtoPdb: 612] [UniProtKB: P48443] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
RAR-related orphan receptor-γ/Nuclear receptor ROR-gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1741186] [GtoPdb: 600] [UniProtKB: P51449]
ChEMBL	Inverse agonist activity at human RoRc-LBD fusion protein with GST expressed in BL-21 (BL3) cells assessed as SRC1 coactivator peptide recruitment	B	5.05	pEC50	9000	nM	EC50	J Med Chem (2014) 57: 5871-5892 [PMID:24502334]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	4.8	pIC50	15848.93	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276]
ChEMBL	Binding affinity for Retinoic acid receptor alpha	B	7.44	pKd	36	nM	Kd	Bioorg Med Chem Lett (1997) 7: 2373-2378
ChEMBL	Binding affinity to retinoic acid receptor alpha using [3H]CD 367 as radioligand	B	7.68	pKi	21	nM	Ki	J Med Chem (1995) 38: 4993-5006 [PMID:8544175]
GtoPdb	-	-	7.44	pIC50	-	-	-	Mol Cell Biol (1994) 14: 287-98 [PMID:8264595]; J Mol Biol (2000) 302: 155-70 [PMID:10964567]; Mol Cell Biol (1995) 15: 3540-51 [PMID:7791761]; Curr Pharm Des (2000) 6: 25-58 [PMID:10637371]
ChEMBL	Binding affinity against retinoic Acid alpha receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay	B	7.44	pIC50	36	nM	IC50	J Med Chem (1994) 37: 408-414 [PMID:8308867]
ChEMBL	Effective concentration against RAR-alpha receptor	B	7.07	pEC50	85	nM	EC50	J Med Chem (1993) 36: 2605-2613 [PMID:8410972]
ChEMBL	Transactivation potency for Retinoic acid receptor alpha	B	7.52	pEC50	30	nM	EC50	Bioorg Med Chem Lett (1997) 7: 2373-2378
ChEMBL	Binding affinity against retinoic Acid alpha receptors co-transfected into CV-1 cells	B	7.52	pEC50	30	nM	EC50	J Med Chem (1994) 37: 408-414 [PMID:8308867]
ChEMBL	Agonist activity for retinoic acid receptor RAR alpha in transcriptional activation assay	F	7.52	pEC50	30	nM	EC50	Bioorg Med Chem Lett (1995) 5: 2729-2734
ChEMBL	Transcriptional activation of retinoic acid receptor RAR alpha	B	7.68	pEC50	21	nM	EC50	Bioorg Med Chem Lett (1995) 5: 523-527
ChEMBL	Transcriptional activation of Retinoic acid receptor RAR alpha	B	7.68	pEC50	21	nM	EC50	J Med Chem (1995) 38: 2820-2829 [PMID:7636843]
ChEMBL	Transcriptional activation for RAR alpha receptor	B	7.68	pEC50	21	nM	EC50	Bioorg Med Chem Lett (1994) 4: 1447-1452
ChEMBL	Agonist activity at human RARalpha expressed in HEK293 cells by luciferase reporter gene assay	B	9.74	pEC50	0.18	nM	EC50	Bioorg Med Chem Lett (2014) 24: 5265-5267 [PMID:25305688]
Retinoic acid receptor-β/Retinoic acid receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826]
ChEMBL	Binding affinity for Retinoic acid receptor beta	B	8.3	pKd	5	nM	Kd	Bioorg Med Chem Lett (1997) 7: 2373-2378
ChEMBL	Binding affinity to retinoic acid receptor beta using [3H]CD 367 as radioligand	B	8.3	pKi	5	nM	Ki	J Med Chem (1995) 38: 4993-5006 [PMID:8544175]
ChEMBL	Binding affinity towards cRAR-beta-2 receptor by displacing 0.82 nM 3[H]all-trans-RA	B	9.3	pKi	0.5	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2313-2318
ChEMBL	Binding affinity towards cRAR-beta-2 receptor by displacing 1.1 nM 3[H]-9-cis-RA	B	9.3	pKi	0.5	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2313-2318
GtoPdb	-	-	8	pIC50	-	-	-	Mol Cell Biol (1994) 14: 287-98 [PMID:8264595]; J Mol Biol (2000) 302: 155-70 [PMID:10964567]; Mol Cell Biol (1995) 15: 3540-51 [PMID:7791761]; Curr Pharm Des (2000) 6: 25-58 [PMID:10637371]
ChEMBL	Binding affinity against retinoic Acid beta receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay	B	8.3	pIC50	5	nM	IC50	J Med Chem (1994) 37: 408-414 [PMID:8308867]
ChEMBL	Effective concentration against Retinoic acid receptor beta	B	8.22	pEC50	6	nM	EC50	J Med Chem (1993) 36: 2605-2613 [PMID:8410972]
ChEMBL	Transcriptional activation of retinoic acid receptor RAR beta	B	8.4	pEC50	4	nM	EC50	Bioorg Med Chem Lett (1995) 5: 523-527
ChEMBL	Transcriptional activation of Retinoic acid receptor RAR beta	B	8.4	pEC50	4	nM	EC50	J Med Chem (1995) 38: 2820-2829 [PMID:7636843]
ChEMBL	Transcriptional activation for RAR beta receptor	B	8.4	pEC50	4	nM	EC50	Bioorg Med Chem Lett (1994) 4: 1447-1452
ChEMBL	Transactivation potency for Retinoic acid receptor beta	B	8.52	pEC50	3	nM	EC50	Bioorg Med Chem Lett (1997) 7: 2373-2378
ChEMBL	Binding affinity against retinoic Acid beta receptors co-transfected into CV-1 cells	B	8.52	pEC50	3	nM	EC50	J Med Chem (1994) 37: 408-414 [PMID:8308867]
ChEMBL	Agonist activity for retinoic acid receptor RAR beta in transcriptional activation assay	F	8.52	pEC50	3	nM	EC50	Bioorg Med Chem Lett (1995) 5: 2729-2734
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631]
ChEMBL	Binding affinity for Retinoic acid receptor gamma	B	7.59	pKd	26	nM	Kd	Bioorg Med Chem Lett (1997) 7: 2373-2378
ChEMBL	Dissociation constant for Retinoic acid receptor gamma	B	7.59	pKd	26	nM	Kd	J Med Chem (2005) 48: 6212-6219 [PMID:16190748]
ChEMBL	Binding affinity to retinoic acid receptor (RAR) gamma using [3H]CD 367 as radioligand	B	8.3	pKi	5	nM	Ki	J Med Chem (1995) 38: 4993-5006 [PMID:8544175]
ChEMBL	Binding affinity against retinoic Acid gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay	B	7.59	pIC50	26	nM	IC50	J Med Chem (1994) 37: 408-414 [PMID:8308867]
GtoPdb	-	-	7.82	pIC50	-	-	-	Mol Cell Biol (1994) 14: 287-98 [PMID:8264595]; J Mol Biol (2000) 302: 155-70 [PMID:10964567]
ChEMBL	Effective concentration against RAR-gamma receptor	B	7.62	pEC50	24	nM	EC50	J Med Chem (1993) 36: 2605-2613 [PMID:8410972]
ChEMBL	Transcriptional activation of retinoic acid receptor RAR gamma	B	8.62	pEC50	2.4	nM	EC50	Bioorg Med Chem Lett (1995) 5: 523-527
ChEMBL	Transcriptional activation of Retinoic acid receptor RAR gamma	B	8.62	pEC50	2.4	nM	EC50	J Med Chem (1995) 38: 2820-2829 [PMID:7636843]
ChEMBL	Transcriptional activation for RAR gamma receptor	B	8.62	pEC50	2.4	nM	EC50	Bioorg Med Chem Lett (1994) 4: 1447-1452
ChEMBL	Transactivation potency for Retinoic acid receptor gamma	B	8.7	pEC50	2	nM	EC50	Bioorg Med Chem Lett (1997) 7: 2373-2378
ChEMBL	Binding affinity against retinoic Acid gamma receptors co-transfected into CV-1 cells	B	8.7	pEC50	2	nM	EC50	J Med Chem (1994) 37: 408-414 [PMID:8308867]
ChEMBL	Agonist activity for retinoic acid receptor RAR gamma in transcriptional activation assay	F	8.7	pEC50	2	nM	EC50	Bioorg Med Chem Lett (1995) 5: 2729-2734
Retinoid X receptor-α/Retinoid X receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793]
ChEMBL	Binding affinity against retinoic Acid X alpha receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay	B	6	pIC50	>1000	nM	IC50	J Med Chem (1994) 37: 408-414 [PMID:8308867]
ChEMBL	Transcriptional activation of retinoid X receptor RXR alpha; not active	B	5	pEC50	10000	nM	EC50	Bioorg Med Chem Lett (1995) 5: 523-527
ChEMBL	Binding affinity against retinoic Acid X alpha receptors co-transfected into CV-1 cells	B	5	pEC50	>10000	nM	EC50	J Med Chem (1994) 37: 408-414 [PMID:8308867]
Retinoid X receptor-β/Retinoid X receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1870] [GtoPdb: 611] [UniProtKB: P28702]
ChEMBL	Binding affinity against retinoic Acid X beta receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay	B	6	pIC50	>1000	nM	IC50	J Med Chem (1994) 37: 408-414 [PMID:8308867]
ChEMBL	Binding affinity against retinoic Acid X beta receptors co-transfected into CV-1 cells	B	5	pEC50	>10000	nM	EC50	J Med Chem (1994) 37: 408-414 [PMID:8308867]
Retinoid X receptor-γ/Retinoid X receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2004] [GtoPdb: 612] [UniProtKB: P48443]
ChEMBL	Binding affinity against retinoic Acid X gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay	B	6	pIC50	>1000	nM	IC50	J Med Chem (1994) 37: 408-414 [PMID:8308867]
ChEMBL	Binding affinity against retinoic Acid X gamma receptors co-transfected into CV-1 cells	B	5	pEC50	>10000	nM	EC50	J Med Chem (1994) 37: 408-414 [PMID:8308867]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]