GW2433 [Ligand Id: 2716] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL435278 (GW2433)
  • Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869]
  • Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Mouse [ChEMBL: CHEMBL2128] [GtoPdb: 593] [UniProtKB: P23204]
  • This target only has 0 pki data point
  • 0
1 CHEMBL435278_lig_chart_1 Peroxisome proliferator-activated receptor alpha HumanMouse
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  • Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181]
  • Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Mouse [ChEMBL: CHEMBL2458] [GtoPdb: 594] [UniProtKB: P35396]
  • This target only has 0 pki data point
  • 0
2 CHEMBL435278_lig_chart_2 Peroxisome proliferator-activated receptor delta HumanMouse
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  • Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
  • Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Mouse [ChEMBL: CHEMBL2459] [GtoPdb: 595] [UniProtKB: P37238]
  • This target only has 0 pki data point
  • 0
3 CHEMBL435278_lig_chart_3 Peroxisome proliferator-activated receptor gamma HumanMouse
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869]
ChEMBL Agonist activity for Human PPAR alpha receptor in transcriptional activation assay F 6.77 pEC50 170 nM EC50 J. Med. Chem. (2000) 43: 527-550 [PMID:10691680]
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2128] [GtoPdb: 593] [UniProtKB: P23204]
ChEMBL Agonist activity for murine PPAR alpha receptor in transcriptional activation assay F 6.57 pEC50 270 nM EC50 J. Med. Chem. (2000) 43: 527-550 [PMID:10691680]
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181]
GtoPdb - - 6.6 pEC50 - - - J Med Chem (2000) 43: 527-50 [PMID:10691680];
Chem Biol (1997) 4: 909-18 [PMID:9427656]
ChEMBL Agonist activity for Human PPAR delta receptor in transcriptional activation assay F 6.72 pEC50 190 nM EC50 J. Med. Chem. (2000) 43: 527-550 [PMID:10691680]
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2458] [GtoPdb: 594] [UniProtKB: P35396]
ChEMBL Agonist activity for murine PPAR delta receptor in transcriptional activation assay F 6.39 pEC50 410 nM EC50 J. Med. Chem. (2000) 43: 527-550 [PMID:10691680]
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL Agonist activity for Human PPAR gamma receptor in transcriptional activation assay F 5.6 pEC50 2500 nM EC50 J. Med. Chem. (2000) 43: 527-550 [PMID:10691680]
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2459] [GtoPdb: 595] [UniProtKB: P37238]
ChEMBL Agonist activity for murine PPAR gamma receptor in transcriptional activation assay F 5.82 pEC50 1500 nM EC50 J. Med. Chem. (2000) 43: 527-550 [PMID:10691680]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]