ChEMBL ligand: CHEMBL109581
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276] There should be some charts here, you may need to enable JavaScript!
Retinoic acid receptor-β/Retinoic acid receptor beta in Human [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826] There should be some charts here, you may need to enable JavaScript!
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631] There should be some charts here, you may need to enable JavaScript!
Retinoid X receptor-α/Retinoid X receptor alpha in Human [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793] There should be some charts here, you may need to enable JavaScript!
Retinoid X receptor-β/Retinoid X receptor beta in Human [ChEMBL: CHEMBL1870] [GtoPdb: 611] [UniProtKB: P28702] There should be some charts here, you may need to enable JavaScript!
Retinoid X receptor-γ/Retinoid X receptor gamma in Human [ChEMBL: CHEMBL2004] [GtoPdb: 612] [UniProtKB: P48443] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276]
ChEMBL	Inhibition of [3H]ATRA binding to Retinoic acid receptor RAR alpha	B	5.75	pKi	1791	nM	Ki	J. Med. Chem. (1996) 39: 3229-3234 [PMID:8765503]
ChEMBL	Transcriptional activation of Retinoic acid receptor RAR alpha	B	8.4	pEC50	4	nM	EC50	J. Med. Chem. (1996) 39: 3229-3234 [PMID:8765503]
Retinoic acid receptor-β/Retinoic acid receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826]
ChEMBL	Inhibition of [3H]ATRA binding to Retinoic acid receptor RAR beta	B	5.59	pKi	2587	nM	Ki	J. Med. Chem. (1996) 39: 3229-3234 [PMID:8765503]
ChEMBL	Transcriptional activation of Retinoic acid receptor RAR beta	B	8	pEC50	10	nM	EC50	J. Med. Chem. (1996) 39: 3229-3234 [PMID:8765503]
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631]
ChEMBL	Inhibition of [3H]ATRA binding to Retinoic acid receptor RAR gamma	B	5.22	pKi	6094	nM	Ki	J. Med. Chem. (1996) 39: 3229-3234 [PMID:8765503]
ChEMBL	Transcriptional activation of Retinoic acid receptor RAR gamma	B	6.72	pEC50	192	nM	EC50	J. Med. Chem. (1996) 39: 3229-3234 [PMID:8765503]
Retinoid X receptor-α/Retinoid X receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793]
ChEMBL	Inhibition of [3H]targretin binding to Retinoid X receptor RXR alpha	B	8.1	pKi	8	nM	Ki	J. Med. Chem. (1996) 39: 3229-3234 [PMID:8765503]
GtoPdb	-	-	8.5	pIC50	-	-	-	Mol Endocrinol (2001) 15: 1360-9 [PMID:11463859]
ChEMBL	Transcriptional ativation of Retinoid X receptor RXR alpha	B	8.7	pEC50	2	nM	EC50	J. Med. Chem. (1996) 39: 3229-3234 [PMID:8765503]
Retinoid X receptor-β/Retinoid X receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1870] [GtoPdb: 611] [UniProtKB: P28702]
ChEMBL	Inhibition of [3H]-Targretin binding to Retinoid X receptor RXR beta	B	8.05	pKi	9	nM	Ki	J. Med. Chem. (1996) 39: 3229-3234 [PMID:8765503]
GtoPdb	-	-	8	pIC50	-	-	-	Mol Endocrinol (2001) 15: 1360-9 [PMID:11463859]; J Biol Chem (2002) 277: 12503-6 [PMID:11877384]; Nature (1996) 383: 450-3 [PMID:8837780]
ChEMBL	Transcriptional activation of Retinoid X receptor RXR beta	B	7.89	pEC50	13	nM	EC50	J. Med. Chem. (1996) 39: 3229-3234 [PMID:8765503]
Retinoid X receptor-γ/Retinoid X receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2004] [GtoPdb: 612] [UniProtKB: P48443]
ChEMBL	Inhibition of [3H]targretin binding to Retinoid X receptor RXR gamma	B	7.85	pKi	14	nM	Ki	J. Med. Chem. (1996) 39: 3229-3234 [PMID:8765503]
ChEMBL	Transcriptional activation of Retinoid X receptor RXR gamma	B	8.4	pEC50	4	nM	EC50	J. Med. Chem. (1996) 39: 3229-3234 [PMID:8765503]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]