lumiracoxib [Ligand Id: 2897] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL404108 (Lumiracoxib, Prexige, COX-189)
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL Inhibition of COX1 B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2007) 50: 1425-1441 [PMID:17341061]
ChEMBL Inhibition of COX1 B 8.15 pIC50 7 nM IC50 J. Med. Chem. (2012) 55: 2932-2942 [PMID:22236250]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
GtoPdb - - 6.49 pKi 320 nM Ki J Biol Chem (2007) 282: 16379-90 [PMID:17434872]
ChEMBL Inhibition of human COX2 preincubated before addition of [1-14C]arachidonic acid B 6.49 pKi 320 nM Ki J. Biol. Chem. (2007) 282: 16379-16390 [PMID:17434872]
ChEMBL Inhibition of COX2 B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2012) 55: 2932-2942 [PMID:22236250]
ChEMBL Inhibition of human COX2 mediated PGE2 production in human whole blood B 6.85 pIC50 140 nM IC50 J. Biol. Chem. (2007) 282: 16379-16390 [PMID:17434872]
ChEMBL Inhibition of COX2 (unknown origin) B 6.85 pIC50 140 nM IC50 MedChemComm (2015) 6: 2081-2123
ChEMBL Inhibition of human COX2 mediated PGE2 production in IL-1-beta-induced human dermal fibroblast cells B 6.89 pIC50 130 nM IC50 J. Biol. Chem. (2007) 282: 16379-16390 [PMID:17434872]
ChEMBL Inhibition of human COX2 for 17 mins pre-incubated before addition of [1-14C]arachidonic acid B 6.97 pIC50 107 nM IC50 J. Biol. Chem. (2007) 282: 16379-16390 [PMID:17434872]
ChEMBL Inhibition of COX-2 (unknown origin) B 7.22 pIC50 60 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 1516-1520 [PMID:26898334]
ChEMBL Inhibition of COX2 B 8.15 pIC50 7 nM IC50 J. Med. Chem. (2007) 50: 1425-1441 [PMID:17341061]
COX-2 /Cyclooxygenase-2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769]
ChEMBL Inhibition of purified mouse COX-2 assessed as inhibition of PGE2-G/PGD2-G formation preincubated for 3 mins before 2-AG substrate addition measured after 30 seconds by LC-MS-MS method B 7.4 pIC50 40 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 5860-5864 [PMID:24060487]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]