LPA [Ligand Id: 2906] activity data from GtoPdb

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  • LPA4 receptor in Human [GtoPdb: 94] [UniProtKB: Q99677]
  • LPA4 receptor in Mouse [GtoPdb: 94] [UniProtKB: Q8BLG2]
  • This target only has 0 pki data point
  • 0
1 _lig_chart_1 LPA4 receptor HumanMouse
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  • GPR87 in Human [GtoPdb: 122] [UniProtKB: Q9BY21]
  • This target only has 0 pki data point
  • 0
2 _lig_chart_2 GPR87 Human
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  • LPA5 receptor in Human [GtoPdb: 124] [UniProtKB: Q9H1C0]
  • This target only has 0 pki data point
  • 0
3 _lig_chart_3 LPA5 receptor Human
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  • LPA6 receptor in Human [GtoPdb: 163] [UniProtKB: P43657]
  • LPA6 receptor in Mouse [GtoPdb: 163] [UniProtKB: Q8BMC0]
  • This target only has 0 pki data point
  • 0
4 _lig_chart_4 LPA6 receptor HumanMouse
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  • P2RY10 in Human [GtoPdb: 165] [UniProtKB: O00398]
  • This target only has 0 pki data point
  • 0
5 _lig_chart_5 P2RY10 Human
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  • LPA1 receptor in Mouse [GtoPdb: 272] [UniProtKB: P61793]
  • This target only has 0 pki data point
  • 0
6 _lig_chart_6 LPA1 receptor Mouse
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  • LPA2 receptor in Human [GtoPdb: 273] [UniProtKB: Q9HBW0]
  • LPA2 receptor in Mouse [GtoPdb: 273] [UniProtKB: Q9JL06]
  • This target only has 0 pki data point
  • 0
7 _lig_chart_7 LPA2 receptor HumanMouse
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  • LPA3 receptor in Human [GtoPdb: 274] [UniProtKB: Q9UBY5]
  • LPA3 receptor in Mouse [GtoPdb: 274] [UniProtKB: Q9EQ31]
  • This target only has 0 pki data point
  • 0
8 _lig_chart_8 LPA3 receptor HumanMouse
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
LPA4 receptor in Human [GtoPdb: 94] [UniProtKB: Q99677]
GtoPdb - - 7.35 pKd - - - J Biol Chem (2003) 278: 25600-6 [PMID:12724320]
LPA4 receptor in Mouse [GtoPdb: 94] [UniProtKB: Q8BLG2]
GtoPdb - - 7.35 pKd 45 nM Kd J Biol Chem (2003) 278: 25600-6 [PMID:12724320]
GPR87 in Human [GtoPdb: 122] [UniProtKB: Q9BY21]
GtoPdb - - 7.44 pEC50 - - - Biochem Biophys Res Commun (2007) 363: 861-6 [PMID:17905198];
Biochem Biophys Res Commun (2008) 371: 707-12 [PMID:18466763]
LPA5 receptor in Human [GtoPdb: 124] [UniProtKB: Q9H1C0]
GtoPdb - - 8.19 pKd 6.4 nM Kd J Pharmacol Exp Ther (2006) 318: 619-28 [PMID:16651401]
GtoPdb - - 7.9 pEC50 - - - J Biol Chem (2008) 283: 21054-64 [PMID:18499677];
Bioorg Med Chem (2010) 18: 477-95 [PMID:20056548];
J Biomol Screen (2013) 18: 599-609 [PMID:23396314]
LPA6 receptor in Human [GtoPdb: 163] [UniProtKB: P43657]
GtoPdb - - 6 pEC50 - - - J Biol Chem (2009) 284: 17731-41 [PMID:19386608];
Nat Genet (2008) 40: 329-34 [PMID:18297070]
LPA6 receptor in Mouse [GtoPdb: 163] [UniProtKB: Q8BMC0]
GtoPdb - - 6 pEC50 1000 nM EC50 J Biol Chem (2009) 284: 17731-41 [PMID:19386608]
P2RY10 in Human [GtoPdb: 165] [UniProtKB: O00398]
GtoPdb - - 6.9 pEC50 - - - Biochem Biophys Res Commun (2008) 371: 707-12 [PMID:18466763]
LPA1 receptor in Mouse [GtoPdb: 272] [UniProtKB: P61793]
GtoPdb - - 8.3 pEC50 5 nM EC50 Curr Med Chem (2008) 15: 2122-31 [PMID:18781939];
J Cell Biol (1996) 135: 1071-83 [PMID:8922387];
J Neurosci (2010) 30: 7300-9 [PMID:20505096]
LPA2 receptor in Human [GtoPdb: 273] [UniProtKB: Q9HBW0]
GtoPdb - - 8.16 pEC50 - - - Mol Pharmacol (2000) 57: 753-9 [PMID:10727522];
Bioorg Med Chem Lett (2004) 14: 3473-6 [PMID:15177455]
LPA2 receptor in Mouse [GtoPdb: 273] [UniProtKB: Q9JL06]
GtoPdb - - 8.17 pEC50 6.8 nM EC50 Curr Med Chem (2008) 15: 2122-31 [PMID:18781939];
J Biol Chem (1998) 273: 7906-10 [PMID:9525886]
LPA3 receptor in Human [GtoPdb: 274] [UniProtKB: Q9UBY5]
GtoPdb - - 6.69 pKd - - - J Biol Chem (1999) 274: 27776-85 [PMID:10488122]
LPA3 receptor in Mouse [GtoPdb: 274] [UniProtKB: Q9EQ31]
GtoPdb - - 6.6 pEC50 253 nM EC50 Curr Med Chem (2008) 15: 2122-31 [PMID:18781939]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.