VPC44116 [Ligand Id: 2930] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL389033
  • S1P1 receptor/Sphingosine 1-phosphate receptor Edg-1 in Human [ChEMBL: CHEMBL4333] [GtoPdb: 275] [UniProtKB: P21453]
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  • S1P3 receptor/Sphingosine 1-phosphate receptor Edg-3 in Human [ChEMBL: CHEMBL3892] [GtoPdb: 277] [UniProtKB: Q99500]
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  • S1P4 receptor/Sphingosine 1-phosphate receptor Edg-6 in Human [ChEMBL: CHEMBL3230] [GtoPdb: 278] [UniProtKB: O95977]
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  • S1P5 receptor/Sphingosine 1-phosphate receptor Edg-8 in Human [ChEMBL: CHEMBL2274] [GtoPdb: 279] [UniProtKB: Q9H228]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
S1P1 receptor/Sphingosine 1-phosphate receptor Edg-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4333] [GtoPdb: 275] [UniProtKB: P21453]
ChEMBL Displacement of [32P]S1P from human S1P1 receptor expressed in HEK293T cells B 7.52 pKi 30 nM Ki Bioorg. Med. Chem. (2007) 15: 663-677 [PMID:17113298]
GtoPdb - - 8.52 pKi 3 nM Ki Bioorg. Med. Chem. (2007) 15: 663-77 [PMID:17113298]
GtoPdb - - 7.57 pIC50 - - - Bioorg. Med. Chem. (2007) 15: 663-77 [PMID:17113298]
S1P3 receptor/Sphingosine 1-phosphate receptor Edg-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3892] [GtoPdb: 277] [UniProtKB: Q99500]
GtoPdb - - 6.52 pKi 300 nM Ki Bioorg. Med. Chem. (2007) 15: 663-77 [PMID:17113298]
ChEMBL Displacement of [32P]S1P from human S1P3 receptor expressed in HEK293T cells B 6.52 pKi 300 nM Ki Bioorg. Med. Chem. (2007) 15: 663-677 [PMID:17113298]
S1P4 receptor/Sphingosine 1-phosphate receptor Edg-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3230] [GtoPdb: 278] [UniProtKB: O95977]
ChEMBL Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay F 5.21 pEC50 6100 nM EC50 Bioorg. Med. Chem. (2007) 15: 663-677 [PMID:17113298]
S1P5 receptor/Sphingosine 1-phosphate receptor Edg-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2274] [GtoPdb: 279] [UniProtKB: Q9H228]
ChEMBL Activity at human S1P5 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay F 7.48 pEC50 33 nM EC50 Bioorg. Med. Chem. (2007) 15: 663-677 [PMID:17113298]
GtoPdb - - 7.5 pEC50 - - - Bioorg. Med. Chem. (2007) 15: 663-77 [PMID:17113298]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]