compound 9a [Patil et al., 1989] [Ligand Id: 2958] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL483819
  • hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035]
GtoPdb Inhibition of HMG-CoA reductase - 5.3 pIC50 5000 nM IC50 J. Nat. Prod. (1989) 52: 153-161
ChEMBL Inhibition of human HMGCoA reductase B 5.3 pIC50 5000 nM IC50 J. Nat. Prod. (1989) 52: 153-161

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]