ChEMBL ligand: CHEMBL41342 (Geranyl Diphosphate)
mevalonate kinase in Human [GtoPdb: 640] [UniProtKB: Q03426] mevalonate kinase in Rat [GtoPdb: 640] [UniProtKB: P17256] There should be some charts here, you may need to enable JavaScript!
diphosphomevalonate decarboxylase in Rat [GtoPdb: 642] [UniProtKB: Q62967] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
mevalonate kinase in Human [GtoPdb: 640] [UniProtKB: Q03426]
GtoPdb	recombinant enzyme expressed in E coli cells. Spectrophotometric assay	-	6.94	pKi	116	nM	Ki	J Lipid Res (1997) 38: 2216-23 [PMID:9392419]
mevalonate kinase in Rat [GtoPdb: 640] [UniProtKB: P17256]
GtoPdb	in vitro assay, enzyme expressed in E coli, purified	-	5.3	pIC50	5000	nM	IC50	Org Lett (2006) 8: 1013-6 [PMID:16524256]
diphosphomevalonate decarboxylase in Rat [GtoPdb: 642] [UniProtKB: Q62967]
GtoPdb	expression of rat enzyme in E coli, purification, in vitro spectrophotometric assay	-	5.3	pIC50	5000	nM	IC50	Biochim Biophys Acta (2006) 1760: 1080-7 [PMID:16626865]; Org Lett (2006) 8: 1013-6 [PMID:16524256]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]