geranylgeranyl diphosphate [Ligand Id: 3052] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1229266
  • mevalonate kinase in Human [GtoPdb: 640] [UniProtKB: Q03426]
  • This target only has 1 pki data point
  • 7.23
1 CHEMBL1229266_lig_chart_1 mevalonate kinase Human
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  • geranylgeranyl diphosphate synthase in Human [GtoPdb: 643] [UniProtKB: O95749]
  • This target only has 1 pki data point
  • 4.6
2 CHEMBL1229266_lig_chart_2 geranylgeranyl diphosphate synthase Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mevalonate kinase in Human [GtoPdb: 640] [UniProtKB: Q03426]
GtoPdb recombinant enzyme expressed in E coli cells. Spectrophotometric assay - 7.23 pKi 59 nM Ki J Lipid Res (1997) 38: 2216-23 [PMID:9392419]
geranylgeranyl diphosphate synthase in Human [GtoPdb: 643] [UniProtKB: O95749]
GtoPdb recombinant human protein expressed in E coli, in vitro assay - 4.6 pKi 25000 nM - J Biol Chem (2006) 281: 22004-12 [PMID:16698791]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]