4-DAMP [Ligand Id: 307] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL168067
  • CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 31253139] [UniProtKB: P0DTD1]
  • This target only has 0 pki data point
  • 0
1 CHEMBL168067_lig_chart_1 Replicase polyprotein 1ab Severe acute respiratory syndrome coronavirus 2
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  • M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
  • M1 receptor in Rat [GtoPdb: 13] [UniProtKB: P08482]
  • 8.9
2 CHEMBL168067_lig_chart_2 M1 receptor HumanRat
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  • M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
  • M2 receptor in Rat [GtoPdb: 14] [UniProtKB: P10980]
  • 8.2
3 CHEMBL168067_lig_chart_3 M2 receptor HumanRat
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  • M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
  • M3 receptor in Rat [GtoPdb: 15] [UniProtKB: P08483]
  • 9.2
4 CHEMBL168067_lig_chart_4 M3 receptor HumanRat
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  • M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
  • M4 receptor in Rat [GtoPdb: 16] [UniProtKB: P08485]
  • 9.1
5 CHEMBL168067_lig_chart_5 M4 receptor HumanRat
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  • M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
  • M5 receptor in Rat [GtoPdb: 17] [UniProtKB: P08911]
  • 8.9
6 CHEMBL168067_lig_chart_6 M5 receptor HumanRat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 31253139] [UniProtKB: P0DTD1]
ChEMBL SARS-CoV-2 3CL-Pro protease inhibition IC50 determined by FRET kind of response from peptide substrate F 5.63 pIC50 2360 nM IC50 Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen
M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb - - 9.3 pKi - - - J Pharmacol Exp Ther (1991) 256: 727-33 [PMID:1994002]
M1 receptor in Rat [GtoPdb: 13] [UniProtKB: P08482]
GtoPdb - - 8.9 pKi - - - Life Sci (1992) 51: 955-71 [PMID:1325587]
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 8.4 pKi - - - J Pharmacol Exp Ther (1991) 256: 727-33 [PMID:1994002]
M2 receptor in Rat [GtoPdb: 14] [UniProtKB: P10980]
GtoPdb - - 8.2 pKi - - - Life Sci (1992) 51: 955-71 [PMID:1325587];
J Pharmacol Exp Ther (1998) 284: 500-7 [PMID:9454790]
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb - - 9.3 pKi - - - J Pharmacol Exp Ther (1991) 256: 727-33 [PMID:1994002]
M3 receptor in Rat [GtoPdb: 15] [UniProtKB: P08483]
GtoPdb - - 9.2 pKi - - - Life Sci (1992) 51: 955-71 [PMID:1325587]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb - - 8.9 pKi - - - J Pharmacol Exp Ther (1991) 256: 727-33 [PMID:1994002]
M4 receptor in Rat [GtoPdb: 16] [UniProtKB: P08485]
GtoPdb - - 9.1 pKi - - - Life Sci (1992) 51: 955-71 [PMID:1325587]
M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
GtoPdb - - 9 pKi - - - J Pharmacol Exp Ther (1991) 256: 727-33 [PMID:1994002]
M5 receptor in Rat [GtoPdb: 17] [UniProtKB: P08911]
GtoPdb - - 8.9 pKi - - - Life Sci (1992) 51: 955-71 [PMID:1325587]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]