compound 5 [PMID: 18754614] [Ligand Id: 3081] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL449619
  • squalene synthase /Squalene synthetase in Rat [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769]
GtoPdb Inhibition of squalene synthase in rat liver microsome measured by convertion of [3H]FPP to squalene - 5.3 pIC50 5000 nM IC50 J Med Chem (2008) 51: 5861-5 [PMID:18754614]
ChEMBL Inhibition of squalene synthase in rat liver microsome measured by conversion of [3H]FPP to squalene B 5.3 pIC50 5000 nM IC50 J. Med. Chem. (2008) 51: 5861-5865 [PMID:18754614]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]