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ChEMBL ligand: CHEMBL449619 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] | ||||||||
GtoPdb | Inhibition of squalene synthase in rat liver microsome measured by convertion of [3H]FPP to squalene | - | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2008) 51: 5861-5 [PMID:18754614] |
ChEMBL | Inhibition of squalene synthase in rat liver microsome measured by conversion of [3H]FPP to squalene | B | 5.3 | pIC50 | 5000 | nM | IC50 | J. Med. Chem. (2008) 51: 5861-5865 [PMID:18754614] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]