[3H]8-OH-DPAT [Ligand Id: 31] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL56
  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
  • Alpha-1a adrenergic receptor in Bovine [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
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  • α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
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  • α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
  • α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944]
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  • Alpha-2a adrenergic receptor in Bovine [ChEMBL: CHEMBL4744] [UniProtKB: Q28838]
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  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
  • Dopamine D2 receptor in Bovine [ChEMBL: CHEMBL3998] [UniProtKB: P20288]
  • D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
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  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
  • D3 receptor/Dopamine D3 receptor in Rat [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020]
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  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
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  • Norepinephrine transporter in Rat [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4]
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
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  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
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  • Serotonin 2a (5-HT2a) receptor in Bovine [ChEMBL: CHEMBL3446] [UniProtKB: Q75Z89]
  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
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  • 5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898]
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  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
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  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL Binding affinity towards human cloned alpha-1A-adrenoceptor using [3H]prazosin as radioligand B 5.76 pKi 1757.2 nM Ki J. Med. Chem. (2001) 44: 2403-2410 [PMID:11448222]
ChEMBL Binding affinity was determined on human cloned Alpha-1A adrenoceptor B 5.76 pKi 1757 nM Ki J. Med. Chem. (2001) 44: 4431-4442 [PMID:11728188]
ChEMBL The binding affinity was evaluated on cloned human alpha-1A adrenergic receptor expressed in chinese hamster ovary(CHO) cells by using [3H]prazosin as radioligand. B 6 pKi <6 nM Log Ki J. Med. Chem. (1999) 42: 2961-2968 [PMID:10425105]
ChEMBL Displacement of [3H]prazosin from human cloned alpha1A adrenoceptor expressed in CHO cells B 6 pKi >1000 nM Ki J. Med. Chem. (2008) 51: 6359-6370 [PMID:18817363]
ChEMBL Displacement of [3H]prazosin from human cloned Alpha-1A adrenergic receptor B 6 pKi <1000 nM Ki J. Med. Chem. (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL Displacement of [3H]prazosin from human recombinant alpha1A adrenergic receptor expressed in CHO cell membranes after 30 mins B 6 pKi >1000 nM Ki J. Med. Chem. (2013) 56: 584-588 [PMID:23252794]
ChEMBL Displacement of [3H]prazosin from human recombinant alpha1A adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting B 6.82 pKi 151.36 nM Ki J. Med. Chem. (2012) 55: 23-36 [PMID:22145629]
ChEMBL Displacement of [3H]prazosin from human alpha1A adrenergic receptor expressed in CHO cells B 6.82 pKi 151.36 nM Ki Bioorg. Med. Chem. Lett. (2010) 20: 2017-2020 [PMID:20185311]
Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
ChEMBL Binding affinity against alpha-1 adrenergic receptor in calf frontal cortex B 4.52 pIC50 30000 nM IC50 J. Med. Chem. (1994) 37: 1779-1793 [PMID:7912735]
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
ChEMBL In vitro binding affinity towards alpha-1A adrenergic receptor through displacement of [3H]prazosin in epididymal rat vas deferens. B 5.68 pKi 2082 nM Ki J. Med. Chem. (2004) 47: 1900-1918 [PMID:15055991]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
ChEMBL Binding affinity was determined on human cloned alpha-1B adrenergic receptor B 5.22 pKi 5975 nM Ki J. Med. Chem. (2001) 44: 4431-4442 [PMID:11728188]
ChEMBL Binding affinity towards human cloned alpha-1B-adrenoceptor using [3H]prazosin as radioligand B 5.22 pKi 5975 nM Ki J. Med. Chem. (2001) 44: 2403-2410 [PMID:11448222]
ChEMBL Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleen B 5.73 pKi 1882 nM Ki J. Med. Chem. (2004) 47: 1900-1918 [PMID:15055991]
ChEMBL The binding affinity was evaluated on cloned human alpha-1B adrenergic receptor expressed in chinese hamster ovary(CHO) cells by using [3H]prazosin as radioligand. B 6 pKi <6 nM Log Ki J. Med. Chem. (1999) 42: 2961-2968 [PMID:10425105]
ChEMBL Displacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting B 6 pKi >1000 nM Ki J. Med. Chem. (2012) 55: 23-36 [PMID:22145629]
ChEMBL Displacement of [3H]prazosin from human cloned Alpha-1B adrenergic receptor B 6 pKi <1000 nM Ki J. Med. Chem. (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL Displacement of [3H]prazosin from human recombinant alpha1B adrenergic receptor expressed in CHO cell membranes after 30 mins B 6 pKi >1000 nM Ki J. Med. Chem. (2013) 56: 584-588 [PMID:23252794]
ChEMBL Displacement of [3H]prazosin from human cloned Alpha-1B adrenoceptor expressed in CHO cells B 6 pKi >1000 nM Ki J. Med. Chem. (2008) 51: 6359-6370 [PMID:18817363]
ChEMBL Displacement of [3H]prazosin from human Alpha-1B adrenergic receptor expressed in CHO cells B 6 pKi >1000 nM Ki Bioorg. Med. Chem. Lett. (2010) 20: 2017-2020 [PMID:20185311]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
ChEMBL The binding affinity was evaluated on cloned human alpha-1D adrenergic receptor expressed in chinese hamster ovary(CHO) cells by using [3H]prazosin as radioligand. B 6 pKi <6 nM Log Ki J. Med. Chem. (1999) 42: 2961-2968 [PMID:10425105]
ChEMBL Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptor B 6 pKi <1000 nM Ki J. Med. Chem. (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL Binding affinity towarda alpha-1D adrenergic receptor B 6 pKi >1000 nM Ki J. Med. Chem. (2001) 44: 4431-4442 [PMID:11728188]
ChEMBL Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand B 6 pKi >1000 nM Ki J. Med. Chem. (2001) 44: 2403-2410 [PMID:11448222]
ChEMBL Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells B 6 pKi >1000 nM Ki J. Med. Chem. (2008) 51: 6359-6370 [PMID:18817363]
ChEMBL Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells B 6 pKi >1000 nM Ki Bioorg. Med. Chem. Lett. (2010) 20: 2017-2020 [PMID:20185311]
ChEMBL Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting B 6 pKi >1000 nM Ki J. Med. Chem. (2012) 55: 23-36 [PMID:22145629]
ChEMBL Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins B 6 pKi >1000 nM Ki J. Med. Chem. (2013) 56: 584-588 [PMID:23252794]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944]
ChEMBL Binding affinity to the adrenergic receptor alpha-1D of rat aorta B 5.27 pKi 5421 nM Ki J. Med. Chem. (2004) 47: 1900-1918 [PMID:15055991]
Alpha-2a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4744] [UniProtKB: Q28838]
ChEMBL Binding affinity against alpha-2 adrenergic receptor in calf frontal cortex B 6 pIC50 1000 nM IC50 J. Med. Chem. (1994) 37: 1779-1793 [PMID:7912735]
Dopamine D1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2967] [UniProtKB: Q95136]
ChEMBL Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum B 4.06 pKi 87300 nM Ki J. Med. Chem. (1997) 40: 952-960 [PMID:9083484]
D1 receptor/Dopamine D1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3071] [GtoPdb: 214] [UniProtKB: Q61616]
ChEMBL Binding affinity against Dopamine receptor D1 B 6 pKi >1000 nM Ki J. Med. Chem. (1997) 40: 952-960 [PMID:9083484]
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
ChEMBL In vitro binding activity against dopamine D1 receptor from homogenized rat brain, using [3H]SCH-23390 as the radioligand B 4 pIC50 >100000 nM IC50 J. Med. Chem. (1989) 32: 2273-2276 [PMID:2571729]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Inhibitory activity against [125I]- NCQ298 binding to dopamine receptor D2 in Sf 9 cells B 5.49 pKi 3243 nM Ki J. Med. Chem. (1993) 36: 3161-3165 [PMID:8230102]
ChEMBL Binding affinity against [3H]U-86,170-labeled dopamine receptor D2 in cloned CHO cells B 7.07 pKi 86 nM Ki J. Med. Chem. (1993) 36: 1053-1068 [PMID:8097537]
ChEMBL Binding affinity against [3H]U-86,170-labeled dopamine receptor D2 in cloned CHO cells B 7.07 pKi 86 nM Ki J. Med. Chem. (1993) 36: 1069-1083 [PMID:8097538]
ChEMBL Binding affinity against Dopamine receptor D2 B 7.08 pKi 84 nM Ki J. Med. Chem. (1997) 40: 952-960 [PMID:9083484]
ChEMBL Inhibitory concentration against binding of Dopamine receptor D2 by displacement of [3H]spiperone B 6 pIC50 >1000 nM IC50 Bioorg. Med. Chem. Lett. (2000) 10: 509-512 [PMID:10743959]
Dopamine D2 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3998] [UniProtKB: P20288]
ChEMBL Inhibition of [3H]raclopride binding to Dopamine receptor D2 of bovine striatum B 5.62 pKi 2380 nM Ki J. Med. Chem. (1997) 40: 952-960 [PMID:9083484]
ChEMBL Compound was evaluated for the binding affinity towards Dopamine receptor D2 using [3H]raclopride radioligand. B 6.1 pIC50 800 nM IC50 J. Med. Chem. (1996) 39: 4285-4298 [PMID:8863806]
ChEMBL Binding affinity against D2 receptor in calf caudate nucleus B 6.1 pIC50 800 nM IC50 J. Med. Chem. (1994) 37: 1779-1793 [PMID:7912735]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL Binding affinity of compound against Dopamine receptor D2 binding site using radioligand [3H]spiperone B 5.46 pKi 3500 nM Ki J. Med. Chem. (1989) 32: 1959-1962 [PMID:2569041]
ChEMBL Binding affinity against D2 receptor in homogenated rat brain tissue, using by [3H]spiperone as radioligand B 5.87 pKi 1357 nM Ki J. Med. Chem. (1993) 36: 3409-3416 [PMID:8230131]
ChEMBL Displacement of [3H]spiperone from dopamine receptor D2 B 5.87 pKi 1357 nM Ki J. Med. Chem. (1993) 36: 2059-2065 [PMID:8340910]
ChEMBL Displacement of the radioligand [3H]spiperone from D2 receptor B 5.87 pKi 1357 nM Ki J. Med. Chem. (1994) 37: 3263-3273 [PMID:7932553]
ChEMBL Binding affinity against Dopamine receptor D2 from CHO-K1 cells, using [3H]U-86,170 as the radioligand. B 5.95 pKi 1126 nM Ki J. Med. Chem. (1995) 38: 2202-2216 [PMID:7783152]
ChEMBL The binding affinity was evaluated on Dopamine receptor D2 expressed in rat striatum by using [3H]spiperone as radioligand B 6 pKi <6 nM Log Ki J. Med. Chem. (1999) 42: 2961-2968 [PMID:10425105]
ChEMBL Binding affinity against [3H]raclopride-labeled dopamine receptor D2 in rat striatum. B 6 pKi >1000 nM Ki J. Med. Chem. (1993) 36: 1053-1068 [PMID:8097537]
ChEMBL Displacement of [3H]spiperone from rat brain Dopamine receptor D2 B 6 pKi <1000 nM Ki J. Med. Chem. (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL Binding affinity for [3H]raclopride-labeled dopamine receptor D2 in rat striatum B 6 pKi >1000 nM Ki J. Med. Chem. (1993) 36: 1069-1083 [PMID:8097538]
ChEMBL Displacement of [3H]YM-09151-2 from rat striatum D2 receptor B 6.26 pKi 549.54 nM Ki J. Med. Chem. (2007) 50: 865-876 [PMID:17300168]
ChEMBL Displacement of [3H]U-86170 from Dopamine receptor D2 B 7.07 pKi 86 nM Ki J. Med. Chem. (1995) 38: 725-734 [PMID:7861420]
ChEMBL Tested in vitro for the inhibition of [3H]raclopride binding to Dopamine receptor D2 in rat striatum B 7.07 pKi 86 nM Ki Bioorg. Med. Chem. Lett. (1997) 7: 2759-2764
ChEMBL The compound was tested in vitro for inhibitory activity against dopamine receptor in rats using [3H]spiperone as radioligand B 5.24 pIC50 5800 nM IC50 J. Med. Chem. (1992) 35: 3984-3990 [PMID:1433207]
ChEMBL In vitro binding activity against Dopamine receptor D2 from homogenized rat brain, using [3H]spiperone as the radioligand B 5.24 pIC50 5760 nM IC50 J. Med. Chem. (1989) 32: 2273-2276 [PMID:2571729]
ChEMBL Binding affinity to rat Dopamine receptor D2 expressed in CHO cells was determined using [125 I ] iodosulpride as radioligand B 8.28 pIC50 5.2 nM IC50 J. Med. Chem. (1996) 39: 3195-3202 [PMID:8759642]
ChEMBL Binding affinity towards rat Dopamine receptor D2 was evaluated using [3H]- spiroperidol as radioligand B 8.28 pIC50 5.2 nM IC50 J. Med. Chem. (1996) 39: 4928-4934 [PMID:8960552]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL Inhibition of [3H]spiperone binding to Dopamine receptor D3 in bovine cortex B 4.84 pKi 14600 nM Ki J. Med. Chem. (1997) 40: 952-960 [PMID:9083484]
ChEMBL Tested in vitro for the inhibition of [3H]U-86170 binding to Dopamine receptor D3, expressed in cloned CHO cells B 6.59 pKi 259 nM Ki Bioorg. Med. Chem. Lett. (1997) 7: 2759-2764
D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020]
ChEMBL Binding affinity against Dopamine receptor D3 from CHO-K1 cells, using [3H]spiperone as the radioligand. B 6.48 pKi 333 nM Ki J. Med. Chem. (1995) 38: 2202-2216 [PMID:7783152]
ChEMBL Inhibitory activity against [125I]- NCQ298 binding to dopamine receptor D3 in Sf 9 cells B 6.6 pKi 251 nM Ki J. Med. Chem. (1993) 36: 3161-3165 [PMID:8230102]
ChEMBL Tested for binding affinity against dopamine receptor D3 expressed in Sf9 cells. B 6.61 pKi 248 nM Ki J. Med. Chem. (1993) 36: 1499-1500 [PMID:8098771]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL Tested in vitro for the inhibition of [3H]spiperone binding to Dopamine receptor D4, expressed in cloned CHO cells B 5.82 pKi >1515 nM Ki Bioorg. Med. Chem. Lett. (1997) 7: 2759-2764
DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977]
ChEMBL Binding affinity against dopamine transporter (DAT) by displacement of [3H]WIN-35428 in male wistar rats B 6 pIC50 >1000 nM IC50 J. Med. Chem. (2003) 46: 5512-5532 [PMID:14640559]
Norepinephrine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4]
ChEMBL Binding affinity against norepinephrine transporter (NET) by displacement of [3H]nisoxetine in male wistar rats B 6 pIC50 >1000 nM IC50 J. Med. Chem. (2003) 46: 5512-5532 [PMID:14640559]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
GtoPdb - - 9.4 pKd 0.4 nM Kd Naunyn Schmiedebergs Arch. Pharmacol. (1999) 359: 447-53 [PMID:10431754];
Naunyn Schmiedebergs Arch. Pharmacol. (1998) 357: 205-17 [PMID:9550290];
Biosci. Rep. (2004) 24: 101-15 [PMID:15628665];
J. Med. Chem. (2000) 43: 4701-10 [PMID:11101361]
ChEMBL Displacement of [3H]WAY100635 from human recombinant 5HT1A receptor B 5.4 pKi 3981.07 nM Ki J. Med. Chem. (2008) 51: 2887-2890 [PMID:18433113]
ChEMBL Displacement of [3H]8-OH-DPAT from human cloned 5-HT1A receptor expressed in human HeLa cells B 5.48 pKi 3300 nM Ki J. Med. Chem. (2008) 51: 7602-7613 [PMID:19053888]
ChEMBL Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 120 mins B 8.29 pKi 5.1 nM Ki J. Med. Chem. (2008) 51: 1492-1495 [PMID:18269229]
ChEMBL Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]8-OH-DPAT) as radioligand B 8.42 pKi 3.8 nM Ki J. Med. Chem. (2004) 47: 1900-1918 [PMID:15055991]
ChEMBL Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor expressed in human HeLa cells B 8.43 pKi 3.71 nM Ki Bioorg. Med. Chem. Lett. (2010) 20: 2017-2020 [PMID:20185311]
ChEMBL Displacement of [3H]-OH-DPAT from human recombinant 5HT1A receptor expressed in HeLa cells after 30 mins by liquid scintillation counting B 8.43 pKi 3.71 nM Ki J. Med. Chem. (2012) 55: 23-36 [PMID:22145629]
ChEMBL Displacement of [3H]8-hydroxy-2-(di-n-propylamino)tetralin from human 5-hydroxytryptamine 1A receptor B 8.46 pKi 3.47 nM Ki J. Med. Chem. (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL Binding affinity towards human cloned 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand B 8.46 pKi 3.44 nM Ki J. Med. Chem. (2001) 44: 2403-2410 [PMID:11448222]
ChEMBL Binding affinity on human cloned 5-hydroxytryptamine 1A receptor transfected in human cell lines(He La) B 8.46 pKi 3.44 nM Ki J. Med. Chem. (2001) 44: 4431-4442 [PMID:11728188]
ChEMBL The binding affinity was evaluated on cloned human 5-hydroxytryptamine 1A receptor expressed in HeLa cells by using DPAT as radioligand. B 8.47 pKi 8.47 nM Log Ki