minodronic acid [Ligand Id: 3164] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL319144 (ONO-5920, YM 529, Minodronic acid, YM-529)
  • farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
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  • Geranylgeranyl pyrophosphate synthase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL1075251] [UniProtKB: Q12051]
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  • geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
GtoPdb Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting - 8.52 pIC50 3 nM IC50 J Med Chem (2010) 53: 3454-64 [PMID:20394422]
ChEMBL Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting B 8.52 pIC50 3 nM IC50 J. Med. Chem. (2010) 53: 3454-3464 [PMID:20394422]
ChEMBL Inhibition of FDPS (unknown origin) B 8.52 pIC50 3 nM IC50 Bioorg Med Chem Lett (2019) 29: 126757-126757 [PMID:31699606]
ChEMBL Inhibition of human FPPS B 8.72 pIC50 1.9 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 1117-1123 [PMID:25630225]
Geranylgeranyl pyrophosphate synthase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075251] [UniProtKB: Q12051]
ChEMBL Binding affinity to Saccharomyces cerevisiae GGPPS B 6.89 pKi 130 nM Ki Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 10022-10027 [PMID:17535895]
ChEMBL Inhibition of Saccharomyces cerevisiae GGPPS B 6.47 pIC50 340 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 10022-10027 [PMID:17535895]
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
ChEMBL Binding affinity to human GGPPS B 5.74 pKi 1800 nM Ki Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 10022-10027 [PMID:17535895]
GtoPdb Inhibition of human recombinant geranylgeranyl diphosphate synthase - 4 pIC50 - - - J Med Chem (2008) 51: 5594-607 [PMID:18800762]
ChEMBL Inhibition of human recombinant geranylgeranyl diphosphate synthase B 4 pIC50 100000 nM IC50 J. Med. Chem. (2008) 51: 5594-5607 [PMID:18800762]
ChEMBL Inhibition of human GGPPS B 4.19 pIC50 65000 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 10022-10027 [PMID:17535895]
GtoPdb Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting - 6.17 pIC50 670 nM IC50 J Med Chem (2010) 53: 3454-64 [PMID:20394422]
ChEMBL Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting B 6.17 pIC50 670 nM IC50 J. Med. Chem. (2010) 53: 3454-3464 [PMID:20394422]
Geranyltranstransferase in Escherichia coli K-12 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075078] [UniProtKB: P22939]
ChEMBL Inhibition of Escherichia coli FPPS B 5.96 pIC50 1100 nM IC50 J. Med. Chem. (2006) 49: 7331-7341 [PMID:17149863]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]