ChEMBL ligand: CHEMBL319144 (Acide minodronique, Acido minodronico, Minodronate, Minodronic acid, NSC-725590, ONO-5920, YM 529, YM-529, YM529)
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] There should be some charts here, you may need to enable JavaScript!
Geranylgeranyl pyrophosphate synthase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL1075251] [UniProtKB: Q12051] There should be some charts here, you may need to enable JavaScript!
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749] There should be some charts here, you may need to enable JavaScript!
Geranyltranstransferase in Escherichia coli [ChEMBL: CHEMBL1075078] [UniProtKB: P22939] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
GtoPdb	Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting	-	8.52	pIC50	3	nM	IC50	J Med Chem (2010) 53: 3454-64 [PMID:20394422]
ChEMBL	Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting	B	8.52	pIC50	3	nM	IC50	J Med Chem (2010) 53: 3454-3464 [PMID:20394422]
ChEMBL	Inhibition of FDPS (unknown origin)	B	8.52	pIC50	3	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126757-126757 [PMID:31699606]
ChEMBL	Inhibition of human FPPS	B	8.72	pIC50	1.9	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1117-1123 [PMID:25630225]
Geranylgeranyl pyrophosphate synthase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075251] [UniProtKB: Q12051]
ChEMBL	Binding affinity to Saccharomyces cerevisiae GGPPS	B	6.89	pKi	130	nM	Ki	Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895]
ChEMBL	Inhibition of Saccharomyces cerevisiae GGPPS	B	6.47	pIC50	340	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895]
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
ChEMBL	Binding affinity to human GGPPS	B	5.74	pKi	1800	nM	Ki	Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895]
GtoPdb	Inhibition of human recombinant geranylgeranyl diphosphate synthase	-	4	pIC50	-	-	-	J Med Chem (2008) 51: 5594-607 [PMID:18800762]
ChEMBL	Inhibition of human recombinant geranylgeranyl diphosphate synthase	B	4	pIC50	100000	nM	IC50	J Med Chem (2008) 51: 5594-5607 [PMID:18800762]
ChEMBL	Inhibition of human GGPPS	B	4.19	pIC50	65000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895]
GtoPdb	Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting	-	6.17	pIC50	670	nM	IC50	J Med Chem (2010) 53: 3454-64 [PMID:20394422]
ChEMBL	Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting	B	6.17	pIC50	670	nM	IC50	J Med Chem (2010) 53: 3454-3464 [PMID:20394422]
Geranyltranstransferase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075078] [UniProtKB: P22939]
ChEMBL	Inhibition of Escherichia coli FPPS	B	5.96	pIC50	1100	nM	IC50	J Med Chem (2006) 49: 7331-7341 [PMID:17149863]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]