PNU109291 [Ligand Id: 3228] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL71838 (PNU-109291) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | The compound was tested for CNS binding affinity towards Dopamine receptor D2 from cloned Human membranes. | B | 6.62 | pKi | 241 | nM | Ki | J Med Chem (1998) 41: 2180-2183 [PMID:9632349] |
| D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| ChEMBL | The compound was tested for CNS binding affinity towards Dopamine receptor D4 from cloned Human membranes. | B | 5.43 | pKi | >3704 | nM | Ki | J Med Chem (1998) 41: 2180-2183 [PMID:9632349] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1A receptor from cloned Human membranes. | B | 5.96 | pKi | 1092 | nM | Ki | J Med Chem (1998) 41: 2180-2183 [PMID:9632349] |
| Serotonin 1b (5-HT1b) receptor in Gorilla (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2304408] [UniProtKB: Q9N2B7] | ||||||||
| ChEMBL | The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1B receptor from cloned gorilla membranes expressed in cultured HEK 293 cells | B | 5.24 | pKi | 5775 | nM | Ki | J Med Chem (1998) 41: 2180-2183 [PMID:9632349] |
| 5-HT1D receptor in Gorilla [GtoPdb: 3] | ||||||||
| GtoPdb | - | - | 9.1 | pKi | 0.9 | nM | Ki | J Med Chem (1998) 41: 2180-3 [PMID:9632349] |
| 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
| ChEMBL | The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells | B | 9.05 | pKi | 0.9 | nM | Ki | J Med Chem (1998) 41: 2180-2183 [PMID:9632349] |
| ChEMBL | Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting | B | 9.05 | pKi | 0.9 | nM | Ki | J Med Chem (2008) 51: 3609-3616 [PMID:18507369] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 2A receptor from cloned Human membranes | B | 6.77 | pKi | 168 | nM | Ki | J Med Chem (1998) 41: 2180-2183 [PMID:9632349] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
