ChEMBL ligand: CHEMBL1210710 (SB-399885)
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
GtoPdb	-	-	9	pKi	1	nM	Ki	Eur J Pharmacol (2006) 553: 109-19 [PMID:17069795]
ChEMBL	Antagonist activity at 5-HT6 receptor (unknown origin)	B	9.1	pKi	0.8	nM	Ki	Bioorg. Med. Chem. (2013) 21: 4614-4627 [PMID:23787290]
ChEMBL	Displacement of [125I]SB-258585 from human recombinant 5HT6 receptor using methiothepin after 45 mins by liquid scintillation spectrometry	B	9.11	pKi	0.78	nM	Ki	Bioorg. Med. Chem. (2011) 19: 5255-5259 [PMID:21821420]
ChEMBL	Displacement of [3H]-LSD from human 5-HT6R expressed in human HeLa cells	B	9.14	pKi	0.72	nM	Ki	Eur J Med Chem (2017) 135: 117-124 [PMID:28441580]
ChEMBL	Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells	B	9.15	pKi	0.7	nM	Ki	J. Med. Chem. (2014) 57: 7160-7181 [PMID:24850589]
ChEMBL	Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	B	9.15	pKi	0.7	nM	Ki	J Med Chem (2021) 64: 13279-13298 [PMID:34467765]
ChEMBL	Antagonist activity at 5-HT6 receptor (unknown origin) expressed in NG108-15 cells assessed as reduction in cAMP level after 5 mins by BRET assay	F	7.01	pIC50	97	nM	IC50	J Med Chem (2021) 64: 13279-13298 [PMID:34467765]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]