L-phenylalanine [Ligand Id: 3313] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL301523 (FEMA NO. 3585, L-phenylalanine, Phenylalanine, NSC-79477)
  • Alkaline phosphatase, tissue-nonspecific isozyme in Human [ChEMBL: CHEMBL5979] [UniProtKB: P05186]
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  • X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170]
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  • Intestinal alkaline phosphatase in Human [ChEMBL: CHEMBL5573] [UniProtKB: P09923]
  • Intestinal alkaline phosphatase in Bovine [ChEMBL: CHEMBL5695] [UniProtKB: P19111]
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  • L-type amino acid transporter 1 in Human [ChEMBL: CHEMBL4459] [GtoPdb: 896] [UniProtKB: Q01650]
  • L-type amino acid transporter 1 in Rat [ChEMBL: CHEMBL4149] [GtoPdb: 896] [UniProtKB: Q63016]
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  • Phospholipase A-2-activating protein in Human [ChEMBL: CHEMBL6114] [UniProtKB: Q9Y263]
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  • Voltage-gated calcium channel alpha2/delta subunit 1 in Mouse [ChEMBL: CHEMBL4676] [UniProtKB: O08532]
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  • GPR139 in Human [GtoPdb: 130] [UniProtKB: Q6DWJ6]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Alkaline phosphatase, tissue-nonspecific isozyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5979] [UniProtKB: P05186]
ChEMBL Inhibition of TNAP by analogous luminescence assay B 5.3 pIC50 >5000 nM IC50 Bioorg. Med. Chem. (2010) 18: 573-579 [PMID:20031422]
X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170]
ChEMBL Inhibition of human IAP expressed in COS7 cells using CDP-star as substrate preincubated for 5 to 10 mins followed by substrate addition measured after 20 mins by luminescence-based assay B 4.1 pIC50 80200 nM IC50 Eur J Med Chem (2018) 156: 461-478 [PMID:30015078]
Intestinal alkaline phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5573] [UniProtKB: P09923]
ChEMBL Inhibition of human IAP expressed in African green monkey COS7 cell membranes using CDP-star as substrate pretreated for 5 to 10 mins followed by substrate addition and measured after 15 to 20 mins by spectrophotometric method B 4 pIC50 100000 nM IC50 Eur J Med Chem (2018) 159: 282-291 [PMID:30296687]
ChEMBL Inhibition of IAP by analogous luminescence assay B 5.3 pIC50 >5000 nM IC50 Bioorg. Med. Chem. (2010) 18: 573-579 [PMID:20031422]
Intestinal alkaline phosphatase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5695] [UniProtKB: P19111]
ChEMBL Inhibition of calf intestinal alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectrophotometric method B 4.1 pIC50 80210 nM IC50 Bioorg. Med. Chem. (2015) 23: 2435-2444 [PMID:25865133]
ChEMBL Inhibition of calf intestinal alkaline phosphatase using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectrophotometric method B 4.1 pIC50 80210 nM IC50 Eur J Med Chem (2017) 126: 408-420 [PMID:27907877]
L-type amino acid transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4459] [GtoPdb: 896] [UniProtKB: Q01650]
ChEMBL Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis relative to BCH B 4.16 pIC50 69000 nM IC50 J Med Chem (2018) 61: 7358-7373 [PMID:30048132]
ChEMBL Cis-inhibition of human LAT1 expressed in TREx HEK293 cells assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis B 4.16 pIC50 69000 nM IC50 Bioorg Med Chem Lett (2019) 29: 2254-2258 [PMID:31248771]
L-type amino acid transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4149] [GtoPdb: 896] [UniProtKB: Q63016]
ChEMBL Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation counting B 4.26 pKi 55000 nM Ki Bioorg. Med. Chem. Lett. (2010) 20: 3688-3691 [PMID:20466543]
Phospholipase A-2-activating protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6114] [UniProtKB: Q9Y263]
ChEMBL Inhibition of PLAP by analogous luminescence assay B 5.3 pIC50 >5000 nM IC50 Bioorg. Med. Chem. (2010) 18: 573-579 [PMID:20031422]
Voltage-gated calcium channel alpha2/delta subunit 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4676] [UniProtKB: O08532]
ChEMBL Displacement of [3H]L-leucine from alpha-2delta containing calcium channel in murine brain B 6.01 pKi 980 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 1138-1141 [PMID:16380257]
ChEMBL Displacement of [3H]L-leucine from alpha-2delta containing calcium channel in murine brain B 6.01 pKi 977.24 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 1138-1141 [PMID:16380257]
GPR139 in Human [GtoPdb: 130] [UniProtKB: Q6DWJ6]
GtoPdb Inhibition equilibrium constant from a radioligand membrane binding assay. - 3.06 pKi 872000 nM Ki Mol Pharmacol (2015) 88: 911-25 [PMID:26349500]
GtoPdb Measured using a GTPγS assay in transfected COS7 cells. - 4.51 pIC50 31000 nM IC50 Mol Pharmacol (2015) 88: 911-25 [PMID:26349500]
GtoPdb - - 3.49 pEC50 320000 nM EC50 J Chem Inf Model (2014) 54: 1553-7 [PMID:24826842]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]