methoxy-MPEP [Ligand Id: 3344] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL332397
  • mGlu5 receptor/Metabotropic glutamate receptor 5 in Human [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594]
  • mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594]
ChEMBL Displacement of [3H]ABP688 from human mGluR5 receptor expressed in L (tk-) cells B 8 pKi 10 nM Ki Bioorg. Med. Chem. (2007) 15: 903-914 [PMID:17110115]
GtoPdb [3H]-M-MPEP displacement assay. - 8.44 pIC50 3.6 nM IC50 Bioorg Med Chem Lett (2002) 12: 407-9 [PMID:11814808]
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
ChEMBL Displacement of [3H]ABP688 from mGluR5 in rat brain membrane B 7.96 pKi 11 nM Ki Bioorg. Med. Chem. (2007) 15: 903-914 [PMID:17110115]
ChEMBL Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay B 8.1 pIC50 8 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 945-949 [PMID:15686891]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]