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ChEMBL ligand: CHEMBL332397 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594] | ||||||||
ChEMBL | Displacement of [3H]ABP688 from human mGluR5 receptor expressed in L (tk-) cells | B | 8 | pKi | 10 | nM | Ki | Bioorg. Med. Chem. (2007) 15: 903-914 [PMID:17110115] |
GtoPdb | [3H]-M-MPEP displacement assay. | - | 8.44 | pIC50 | 3.6 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 407-9 [PMID:11814808] |
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
ChEMBL | Displacement of [3H]ABP688 from mGluR5 in rat brain membrane | B | 7.96 | pKi | 11 | nM | Ki | Bioorg. Med. Chem. (2007) 15: 903-914 [PMID:17110115] |
ChEMBL | Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay | B | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg. Med. Chem. Lett. (2005) 15: 945-949 [PMID:15686891] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]