methoxy-MPEP [Ligand Id: 3344] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL332397 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594] | ||||||||
| ChEMBL | Displacement of [3H]ABP688 from human mGluR5 receptor expressed in L (tk-) cells | B | 8 | pKi | 10 | nM | Ki | Bioorg Med Chem (2007) 15: 903-914 [PMID:17110115] |
| GtoPdb | [3H]-M-MPEP displacement assay. | - | 8.44 | pIC50 | 3.6 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 407-9 [PMID:11814808] |
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
| ChEMBL | Displacement of [3H]ABP688 from mGluR5 in rat brain membrane | B | 7.96 | pKi | 11 | nM | Ki | Bioorg Med Chem (2007) 15: 903-914 [PMID:17110115] |
| ChEMBL | Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay | B | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 945-949 [PMID:15686891] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
