Gö 7874 [Ligand Id: 335] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL157822
  • cGMP-dependent protein kinase 1 alpha in Bovine [ChEMBL: CHEMBL3183] [UniProtKB: P00516]
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  • myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746]
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  • M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
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  • M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
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  • M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
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  • M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cGMP-dependent protein kinase 1 alpha in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3183] [UniProtKB: P00516]
ChEMBL Tested for inhibition of cGMP-dependent protein kinase from bovine lung B 5.32 pIC50 4800 nM IC50 Bioorg Med Chem Lett (1995) 5: 55-60
myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746]
ChEMBL Tested for inhibition of Myosin light chain kinase from chicken gizzard B 6.92 pIC50 120 nM IC50 Bioorg Med Chem Lett (1995) 5: 55-60
M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb - - 5.8 pKd - - - Mol Pharmacol (2000) 58: 194-207 [PMID:10860942]
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 5 pKd - - - Mol Pharmacol (2000) 58: 194-207 [PMID:10860942]
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb - - 5.1 pKd - - - Mol Pharmacol (2000) 58: 194-207 [PMID:10860942]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb - - 5.7 pKd - - - Mol Pharmacol (2000) 58: 194-207 [PMID:10860942]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]