Gö 7874 [Ligand Id: 335] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL157822
  • cGMP-dependent protein kinase 1 alpha in Bovine [ChEMBL: CHEMBL3183] [UniProtKB: P00516]
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  • myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746]
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  • M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
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  • M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
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  • M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
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  • M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cGMP-dependent protein kinase 1 alpha in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3183] [UniProtKB: P00516]
ChEMBL Tested for inhibition of cGMP-dependent protein kinase from bovine lung B 5.32 pIC50 4800 nM IC50 Bioorg Med Chem Lett (1995) 5: 55-60
myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746]
ChEMBL Tested for inhibition of Myosin light chain kinase from chicken gizzard B 6.92 pIC50 120 nM IC50 Bioorg Med Chem Lett (1995) 5: 55-60
M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb - - 5.8 pKd - - - Mol Pharmacol (2000) 58: 194-207 [PMID:10860942]
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 5 pKd - - - Mol Pharmacol (2000) 58: 194-207 [PMID:10860942]
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb - - 5.1 pKd - - - Mol Pharmacol (2000) 58: 194-207 [PMID:10860942]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb - - 5.7 pKd - - - Mol Pharmacol (2000) 58: 194-207 [PMID:10860942]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]