LTE4 [Ligand Id: 3352] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL509456
  • ABCC2/Canalicular multispecific organic anion transporter 1 in Rat [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120]
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  • P2Y12 receptor/Purinergic receptor P2Y12 in Human [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
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  • GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65]
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  • CysLT1 receptor in Human [GtoPdb: 269] [UniProtKB: Q9Y271]
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  • CysLT2 receptor in Human [GtoPdb: 270] [UniProtKB: Q9NS75]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120]
ChEMBL TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells F 5.01 pIC50 9830 nM IC50 Mol Pharmacol (2001) 59: 1077-1085 [PMID:11306690]
P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
ChEMBL Agonist activity at human P2Y12 receptor F 8.89 pEC50 1.3 nM EC50 J Med Chem (2009) 52: 5803-5815 [PMID:19739647]
GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65]
GtoPdb - - 9.51 pEC50 0.31 nM EC50 PLoS ONE (2008) 3: e3579 [PMID:18974869]
CysLT1 receptor in Human [GtoPdb: 269] [UniProtKB: Q9Y271]
GtoPdb - - 7.8 pKi - - - Mol Pharmacol (1998) 53: 750-8 [PMID:9547367]
GtoPdb - - 6.97 pIC50 107 nM IC50 Nature (1999) 399: 789-93 [PMID:10391245]
GtoPdb - - 6.41 pEC50 391 nM EC50 Mol Pharmacol (2011) 79: 270-8 [PMID:21078884]
GtoPdb - - 6.67 pEC50 212 nM EC50 Nature (1999) 399: 789-93 [PMID:10391245]
GtoPdb - - 7.24 pEC50 58 nM EC50 Mol Pharmacol (1999) 56: 657-63 [PMID:10462554];
Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337];
Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801]
CysLT2 receptor in Human [GtoPdb: 270] [UniProtKB: Q9NS75]
GtoPdb - - 6.5 pKi - - - Mol Pharmacol (1998) 53: 750-8 [PMID:9547367]
GtoPdb - - 5.72 pIC50 1890 nM IC50 Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337]
GtoPdb - - 6.16 pIC50 693 nM IC50 J Biol Chem (2000) 275: 30531-6 [PMID:10851239];
Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801]
GtoPdb - - 5.92 pEC50 1208 nM EC50 J Biol Chem (2000) 275: 30531-6 [PMID:10851239];
Mol Pharmacol (2011) 79: 270-8 [PMID:21078884]
GtoPdb - - 7.11 pEC50 77 nM EC50 Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337];
Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]