ICI198615 [Ligand Id: 3358] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL22033 (ICI-198615)
  • Cysteinyl leukotriene receptor 1 in Guinea pig [ChEMBL: CHEMBL5645] [UniProtKB: Q2NNR5]
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  • CysLT1 receptor in Guinea pig [GtoPdb: 269]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cysteinyl leukotriene receptor 1 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5645] [UniProtKB: Q2NNR5]
ChEMBL Dissociation constant for CysLT1 receptor was determined by the displacement of [3H]LTD4 from guinea pig lung membranes B 4.52 pKd 30100 nM Kd Bioorg. Med. Chem. Lett. (1997) 7: 1331-1336
ChEMBL Binding affinity against LTD4 receptor in guinea pig lung membranes. B 9.52 pKi 0.3 nM Ki J. Med. Chem. (1991) 34: 1704-1707 [PMID:1851845]
ChEMBL Compound was evaluated for its ability to displace [3H]LTD4 from LTD4 receptor in guinea pig lung membranes B 9.52 pKi 0.3 nM Ki J. Med. Chem. (1991) 34: 1235-1242 [PMID:1849993]
CysLT1 receptor in Guinea pig [GtoPdb: 269]
GtoPdb - - 9.7 pKi 0.2 nM Ki J Med Chem (1990) 33: 2828-41 [PMID:2170649]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]