12S-HETE [Ligand Id: 3404] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1526258
There should be some charts here, you may need to enable JavaScript!
  • GPR31 in Mouse [GtoPdb: 98] [UniProtKB: F8VQN3]
There should be some charts here, you may need to enable JavaScript!
  • BLT2 receptor in Human [GtoPdb: 268] [UniProtKB: Q9NPC1]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
OXE receptor/Oxoeicosanoid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628461] [GtoPdb: 271] [UniProtKB: Q8TDS5]
ChEMBL Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assay F 6.3 pIC50 500 nM IC50 J Med Chem (2018) 61: 5934-5948 [PMID:29972644]
GPR31 in Mouse [GtoPdb: 98] [UniProtKB: F8VQN3]
GtoPdb - - 9.55 pEC50 0.28 nM EC50 J Biol Chem (2011) 286: 33832-40 [PMID:21712392]
BLT2 receptor in Human [GtoPdb: 268] [UniProtKB: Q9NPC1]
GtoPdb - - 7.52 pEC50 >30 nM EC50 J Biol Chem (2001) 276: 12454-9 [PMID:11278893]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]