[3H]ICI-198615 [Ligand Id: 3414] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL22033 (ICI-198615)
  • Cysteinyl leukotriene receptor 1 in Guinea pig [ChEMBL: CHEMBL5645] [UniProtKB: Q2NNR5]
There should be some charts here, you may need to enable JavaScript!
  • CysLT1 receptor in Human [GtoPdb: 269] [UniProtKB: Q9Y271]
There should be some charts here, you may need to enable JavaScript!
  • CysLT2 receptor in Human [GtoPdb: 270] [UniProtKB: Q9NS75]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cysteinyl leukotriene receptor 1 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5645] [UniProtKB: Q2NNR5]
ChEMBL Dissociation constant for CysLT1 receptor was determined by the displacement of [3H]LTD4 from guinea pig lung membranes B 4.52 pKd 30100 nM Kd Bioorg Med Chem Lett (1997) 7: 1331-1336
ChEMBL Binding affinity against LTD4 receptor in guinea pig lung membranes. B 9.52 pKi 0.3 nM Ki J Med Chem (1991) 34: 1704-1707 [PMID:1851845]
ChEMBL Compound was evaluated for its ability to displace [3H]LTD4 from LTD4 receptor in guinea pig lung membranes B 9.52 pKi 0.3 nM Ki J Med Chem (1991) 34: 1235-1242 [PMID:1849993]
CysLT1 receptor in Human [GtoPdb: 269] [UniProtKB: Q9Y271]
GtoPdb in human lung parenchyma - 10.6 pKd 0.03 nM Kd Biochem Pharmacol (1992) 44: 1411-5 [PMID:1329767]
CysLT2 receptor in Human [GtoPdb: 270] [UniProtKB: Q9NS75]
GtoPdb - - 5.2 pKd - - - Biochem Pharmacol (1992) 44: 1411-5 [PMID:1329767]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]