CDDO-Me [Ligand Id: 3443] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1762621 (CDDO-Me, CDDO-METHYL ESTER, Bardoxolone methyl ester, NSC-713200, Bardoxolone Methyl, RTA-402)
  • nuclear factor, erythroid 2 like 2/Nuclear factor erythroid 2-related factor 2 in Human [ChEMBL: CHEMBL1075094] [GtoPdb: 3057] [UniProtKB: Q16236]
  • This target only has 0 pki data point
1 CHEMBL1762621_lig_chart_1 Nuclear factor erythroid 2-related factor 2 Human
There should be some charts here, you may need to enable JavaScript!
  • signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763]
  • This target only has 0 pki data point
2 CHEMBL1762621_lig_chart_2 Signal transducer and activator of transcription 3 Human
There should be some charts here, you may need to enable JavaScript!
  • ubiquitin specific peptidase 2/Ubiquitin carboxyl-terminal hydrolase 2 in Human [ChEMBL: CHEMBL1293227] [GtoPdb: 2430] [UniProtKB: O75604]
  • This target only has 0 pki data point
3 CHEMBL1762621_lig_chart_3 Ubiquitin carboxyl-terminal hydrolase 2 Human
There should be some charts here, you may need to enable JavaScript!
  • Ubiquitin carboxyl-terminal hydrolase 7 in Human [ChEMBL: CHEMBL2157850] [UniProtKB: Q93009]
  • This target only has 0 pki data point
4 CHEMBL1762621_lig_chart_4 Ubiquitin carboxyl-terminal hydrolase 7 Human
There should be some charts here, you may need to enable JavaScript!
  • Peroxisome proliferator-activated receptor-γ in Human [GtoPdb: 595] [UniProtKB: P37231]
  • This target only has 1 pki data point
5 CHEMBL1762621_lig_chart_5 Peroxisome proliferator-activated receptor-γ Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
nuclear factor, erythroid 2 like 2/Nuclear factor erythroid 2-related factor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075094] [GtoPdb: 3057] [UniProtKB: Q16236]
ChEMBL Activation of Nrf2 (unknown origin) expressed in human HaCaT-ARE-luc cells after 6 hrs by luciferase reporter gene assay B 7.22 pEC50 60 nM EC50 J Nat Prod (2017) 80: 2276-2283 [PMID:28753294]
signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763]
ChEMBL Inhibition of IFN-gamma stimulated STAT3 (unknown origin) expressed in human HeLa cells after 6 hrs by luciferase reporter gene assay B 5.62 pIC50 2380 nM IC50 J Nat Prod (2017) 80: 2276-2283 [PMID:28753294]
ubiquitin specific peptidase 2/Ubiquitin carboxyl-terminal hydrolase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293227] [GtoPdb: 2430] [UniProtKB: O75604]
ChEMBL Inhibition of USP2 (unknown origin) B 4.66 pIC50 22000 nM IC50 J Med Chem (2018) 61: 422-443 [PMID:28768102]
Ubiquitin carboxyl-terminal hydrolase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2157850] [UniProtKB: Q93009]
ChEMBL Inhibition of USP7 (unknown origin) using human N-terminal GST-tagged UBA52 as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by coomassie brilliant blue staining-based SDS-PAGE analysis B 4.85 pIC50 14080 nM IC50 J Med Chem (2018) 61: 422-443 [PMID:28768102]
Peroxisome proliferator-activated receptor-γ in Human [GtoPdb: 595] [UniProtKB: P37231]
GtoPdb - - 6.9 pKi 130 nM Ki Mol. Endocrinol. (2000) 14: 1550-6 [PMID:11043571]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]