[3H]enadoline [Ligand Id: 3475] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL318859 (CI-977, Enadoline) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| ChEMBL | Inhibitory activity against Opioid receptor delta 1 in chinese Hamster Ovary (CHO) cell membranes was determined using [3H]naltrindole radioligand | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2003) 46: 5162-5170 [PMID:14613319] |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| ChEMBL | Inhibitory activity against Opioid receptor kappa 1 in chinese Hamster Ovary (CHO) cell membranes was determined using [3H]U-69593 radioligand | B | 9.57 | pKi | 0.27 | nM | Ki | J Med Chem (2003) 46: 5162-5170 [PMID:14613319] |
| ChEMBL | Inhibition of Opioid receptor kappa 1 as reduced contraction in electrically stimulated rabbit vas deferens | F | 8.48 | pEC50 | 3.3 | nM | EC50 | Bioorg Med Chem Lett (1997) 7: 291-296 |
| κ receptor/Kappa opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975] | ||||||||
| ChEMBL | Compound was evaluated for the inhibition of binding of [3H]U-69593 to cloned rat Opioid receptor kappa 1 expressed in CHO cell line | B | 10 | pKi | 0.1 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 291-296 |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| ChEMBL | Inhibitory activity against Opioid receptor mu 1 in chinese Hamster Ovary (CHO) cells membranes was determined using [3H]-DAMGO radioligand | B | 7.66 | pKi | 22 | nM | Ki | J Med Chem (2003) 46: 5162-5170 [PMID:14613319] |
| μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] | ||||||||
| ChEMBL | Compound was evaluated for the inhibition of binding of [3H]DAGO to rat brain mu opioid receptor | B | 7.06 | pKi | 87.4 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 291-296 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
