N-palmitoylethanolamine [Ligand Id: 3622] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL417675 (Palmidrol, AM 3112, NSC-23320)
  • Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612]
  • This target only has 0 pki data point
  • 0
1 CHEMBL417675_lig_chart_1 Anandamide amidohydrolase Rat
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  • CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
  • This target only has 1 pki data point
  • 5.3
2 CHEMBL417675_lig_chart_2 Cannabinoid CB1 receptor Human
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  • CB2 receptor/Cannabinoid CB2 receptor in Human [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
  • This target only has 1 pki data point
  • 5.3
3 CHEMBL417675_lig_chart_3 Cannabinoid CB2 receptor Human
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  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
  • 0
4 CHEMBL417675_lig_chart_4 Plasmodium falciparum Plasmodium falciparum
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  • TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2]
  • This target only has 0 pki data point
  • 0
5 CHEMBL417675_lig_chart_5 Transient receptor potential cation channel subfamily V member 2 Rat
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  • TRPV1/Vanilloid receptor in Human [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1]
  • This target only has 0 pki data point
  • 0
6 CHEMBL417675_lig_chart_6 Vanilloid receptor Human
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  • GPR55 in Human [GtoPdb: 109] [UniProtKB: Q9Y2T6]
  • This target only has 0 pki data point
  • 0
7 CHEMBL417675_lig_chart_7 GPR55 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612]
ChEMBL Inhibition of rat recombinant FAAH assessed as [3H]AEA hydrolysis B 5.3 pIC50 5011.87 nM IC50 Bioorg. Med. Chem. (2009) 17: 49-56 [PMID:19054678]
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cell membrane B 5.3 pKi >5000 nM Ki J. Med. Chem. (2009) 52: 3001-3009 [PMID:19361197]
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
ChEMBL Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cell membrane B 5.3 pKi >5000 nM Ki J. Med. Chem. (2009) 52: 3001-3009 [PMID:19361197]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay F 5.5 pIC50 3162.28 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay F 6.3 pIC50 501.19 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2]
ChEMBL Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry B 5 pIC50 >10000 nM IC50 J Med Chem (2018) 61: 8255-8281 [PMID:30176215]
ChEMBL Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry B 5 pIC50 >10000 nM IC50 J Med Chem (2018) 61: 8255-8281 [PMID:30176215]
TRPV1/Vanilloid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1]
ChEMBL Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level F 5 pEC50 >10000 nM EC50 J. Med. Chem. (2009) 52: 3001-3009 [PMID:19361197]
GPR55 in Human [GtoPdb: 109] [UniProtKB: Q9Y2T6]
GtoPdb - - 8.4 pEC50 4 nM EC50 Br J Pharmacol (2007) 152: 1092-101 [PMID:17876302]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]