ACTH [Ligand Id: 3633] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1201610 (Cortrophin, H.p. acthar gel, Corticotropin, Adrenomone, Cortigel, Corticotropin, repository, Adrenocorticotropin, Acth, Acthar, Repository corticotropin, Purified cortrophin gel, Acthar gel, Adrenocorticotropic Hormone)
  • MC1 receptor in Human [GtoPdb: 282] [UniProtKB: Q01726]
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  • MC3 receptor in Human [GtoPdb: 284] [UniProtKB: P41968]
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  • MC4 receptor in Human [GtoPdb: 285] [UniProtKB: P32245]
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  • MC5 receptor in Human [GtoPdb: 286] [UniProtKB: P33032]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MC1 receptor in Human [GtoPdb: 282] [UniProtKB: Q01726]
GtoPdb - - 8.6 pKi 2.5 nM Ki Eur J Pharmacol (1995) 288: 311-317 [PMID:7774675]
MC3 receptor in Human [GtoPdb: 284] [UniProtKB: P41968]
GtoPdb - - 7.06 pKi 86.9 nM Ki Eur J Pharmacol (1995) 288: 311-317 [PMID:7774675]
MC4 receptor in Human [GtoPdb: 285] [UniProtKB: P32245]
GtoPdb - - 6.16 pKi 693 nM Ki Pharmacol Toxicol (1996) 79: 161-5 [PMID:8884876]
MC5 receptor in Human [GtoPdb: 286] [UniProtKB: P33032]
GtoPdb - - 5 pKi >10000 nM Ki Eur J Pharmacol (1995) 288: 311-317 [PMID:7774675]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]