ACTH [Ligand Id: 3633] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1201610 (Acth, Acthar, Acthar gel, Adrenocorticotropic Hormone, Adrenocorticotropin, Adrenomone, Corticotropin, Corticotropin, repository, Cortigel, Cortrophin, H.p. acthar gel, Purified cortrophin gel, Repository corticotropin)
  • MC1 receptor in Human [GtoPdb: 282] [UniProtKB: Q01726]
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  • MC3 receptor in Human [GtoPdb: 284] [UniProtKB: P41968]
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  • MC4 receptor in Human [GtoPdb: 285] [UniProtKB: P32245]
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  • MC5 receptor in Human [GtoPdb: 286] [UniProtKB: P33032]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MC1 receptor in Human [GtoPdb: 282] [UniProtKB: Q01726]
GtoPdb - - 8.6 pKi 2.5 nM Ki Eur J Pharmacol (1995) 288: 311-317 [PMID:7774675]
MC3 receptor in Human [GtoPdb: 284] [UniProtKB: P41968]
GtoPdb - - 7.06 pKi 86.9 nM Ki Eur J Pharmacol (1995) 288: 311-317 [PMID:7774675]
MC4 receptor in Human [GtoPdb: 285] [UniProtKB: P32245]
GtoPdb - - 6.16 pKi 693 nM Ki Pharmacol Toxicol (1996) 79: 161-5 [PMID:8884876]
MC5 receptor in Human [GtoPdb: 286] [UniProtKB: P33032]
GtoPdb - - 5 pKi >10000 nM Ki Eur J Pharmacol (1995) 288: 311-317 [PMID:7774675]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]