buserelin [Ligand Id: 3860] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2110824 (Buserelin, Suprecur, Suprefact)
  • GnRH1 receptor in Human [GtoPdb: 256] [UniProtKB: P30968]
  • GnRH1 receptor in Mouse [GtoPdb: 256] [UniProtKB: Q01776]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GnRH1 receptor in Human [GtoPdb: 256] [UniProtKB: P30968]
GtoPdb - - 10.4 pKd 0.04 nM Kd Br J Pharmacol (2016) 173: 128-41 [PMID:26398856];
Biosens Bioelectron (2016) 79: 721-7 [PMID:26774084]
GtoPdb - - 10 pKi 0.1 nM Ki Br J Pharmacol (2016) 173: 128-41 [PMID:26398856]
GtoPdb - - 10.52 pEC50 0.03 nM EC50 Biosens Bioelectron (2016) 79: 721-7 [PMID:26774084]
GnRH1 receptor in Mouse [GtoPdb: 256] [UniProtKB: Q01776]
GtoPdb - - 10.05 pEC50 0.09 nM EC50 Biosens Bioelectron (2016) 79: 721-7 [PMID:26774084]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]