NS9283 [Ligand Id: 3993] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3103988
  • nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human [ChEMBL: CHEMBL1907589] [GtoPdb: 472, 465] [UniProtKB: P17787, P43681]
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  • nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α5 subunit/nicotinic acetylcholine receptor α4 subunit/Nicotinic acetylcholine receptor alpha4/beta2/alpha5 in Human [ChEMBL: CHEMBL3038461] [GtoPdb: 472, 466, 465] [UniProtKB: P17787, P30532, P43681]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907589] [GtoPdb: 472, 465] [UniProtKB: P17787, P43681]
ChEMBL Positive allosteric modulation of alpha4beta2 nACHR (unknown origin) B 6 pEC50 990 nM EC50 Bioorg. Med. Chem. Lett. (2014) 24: 674-678 [PMID:24365158]
nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α5 subunit/nicotinic acetylcholine receptor α4 subunit/Nicotinic acetylcholine receptor alpha4/beta2/alpha5 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038461] [GtoPdb: 472, 466, 465] [UniProtKB: P17787, P30532, P43681]
ChEMBL Positive allosteric modulation of human alpha4beta2alpha5 nACHR expressed in HEK-tsA201 cells assessed as potentiation of nicotine-induced current preincubated for 15 mins followed by nicotine-treatment by fluorometric analysis B 6.1 pEC50 790 nM EC50 Bioorg. Med. Chem. Lett. (2014) 24: 674-678 [PMID:24365158]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]