WAY200070 [Ligand Id: 4052] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL188528
  • Estrogen receptor-α/Estrogen receptor alpha in Human [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372]
  • Estrogen receptor-α/Estrogen receptor alpha in Mouse [ChEMBL: CHEMBL3065] [GtoPdb: 620] [UniProtKB: P19785]
  • Estrogen receptor-α/Estrogen receptor alpha in Rat [ChEMBL: CHEMBL2724] [GtoPdb: 620] [UniProtKB: P06211]
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  • Estrogen receptor-β/Estrogen receptor beta in Human [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731]
  • Estrogen receptor-β/Estrogen receptor beta in Mouse [ChEMBL: CHEMBL2995] [GtoPdb: 621] [UniProtKB: O08537]
  • Estrogen receptor-β/Estrogen receptor beta in Rat [ChEMBL: CHEMBL3021] [GtoPdb: 621] [UniProtKB: Q62986]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372]
ChEMBL Inhibitory concentration against human ER alpha expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligand B 6.81 pIC50 155 nM IC50 J. Med. Chem. (2004) 47: 5021-5040 [PMID:15456246]
GtoPdb - - 6.81 pEC50 155 nM EC50 Neuropharmacology (2008) 54: 1136-42 [PMID:18423777]
Estrogen receptor-α/Estrogen receptor alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3065] [GtoPdb: 620] [UniProtKB: P19785]
ChEMBL Inhibition of [3H]17-beta-estradiol binding to mouse ER alpha expressed in Escherichia coli B 6.88 pIC50 132 nM IC50 J. Med. Chem. (2004) 47: 5021-5040 [PMID:15456246]
Estrogen receptor-α/Estrogen receptor alpha in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2724] [GtoPdb: 620] [UniProtKB: P06211]
ChEMBL Inhibition of [3H]17-beta-estradiol binding to rat ER alpha expressed in Escherichia coli B 6.88 pIC50 132 nM IC50 J. Med. Chem. (2004) 47: 5021-5040 [PMID:15456246]
Estrogen receptor-β/Estrogen receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731]
ChEMBL Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligand B 8.7 pIC50 2 nM IC50 J. Med. Chem. (2004) 47: 5021-5040 [PMID:15456246]
ChEMBL Binding affinity to ERbeta B 8.7 pIC50 2 nM IC50 Eur. J. Med. Chem. (2008) 43: 43-52 [PMID:17459530]
ChEMBL Binding affinity to ERbeta B 8.85 pIC50 1.4 nM IC50 Eur. J. Med. Chem. (2008) 43: 43-52 [PMID:17459530]
GtoPdb - - 9 pIC50 1 nM IC50 J Med Chem (2004) 47: 5021-40 [PMID:15456246]
GtoPdb - - 8.7 pEC50 2 nM EC50 Neuropharmacology (2008) 54: 1136-42 [PMID:18423777]
Estrogen receptor-β/Estrogen receptor beta in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2995] [GtoPdb: 621] [UniProtKB: O08537]
ChEMBL Inhibition of [3H]17-beta-estradiol binding to mouse ER beta expressed in Escherichia coli B 8.77 pIC50 1.7 nM IC50 J. Med. Chem. (2004) 47: 5021-5040 [PMID:15456246]
Estrogen receptor-β/Estrogen receptor beta in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3021] [GtoPdb: 621] [UniProtKB: Q62986]
ChEMBL Inhibition of [3H]17-beta-estradiol binding to rat ER beta expressed in Escherichia coli B 8.92 pIC50 1.2 nM IC50 J. Med. Chem. (2004) 47: 5021-5040 [PMID:15456246]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]