aspirin [Ligand Id: 4139] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL25 (Disprin Cv, Micropirin EC, Salicylic Acid Acetate, Postmi 75, NSC-406186, Acetosalic Acid, Acetylsalic Acid, Aspirin, Durlaza, Equi-Prin, Vazalore, Disprin Direct, Max Strgh Aspro Clr, Nu-Seals 300, Postmi 300, Platet, Bayer Extra Strength, 8-Hour Bayer, Enprin, Nu-Seals 600, Anadin All Night, Aspro Clr, Platet 300, Angettes 75, Ecotrin, Alka Rapid, Nu-Seals 75, Acetylsalicylic Acid, Gencardia, Levius, Measurin, Paynocil, BAY1019036, Danamep, NSC-27223, Nu-Seals Cardio 75)
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  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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  • Gamma-glutamyltranspeptidase 1 in Human [ChEMBL: CHEMBL5696] [UniProtKB: P19440]
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  • integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha 2 subunit (CD49B, alpha 2 subunit of VLA-2 receptor)/Integrin alpha-IIb/beta-3 in Human [ChEMBL: CHEMBL2093869] [GtoPdb: 24572440] [UniProtKB: P05106P08514]
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  • ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method B 4.21 pKi 62000 nM Ki J. Med. Chem. (2013) 56: 8377-8388 [PMID:24088053]
GtoPdb - - 3.25 pIC50 560100 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 6855-61 [PMID:19884005]
ChEMBL Inhibition of COX1 B 4 pIC50 100000 nM IC50 J. Med. Chem. (2008) 51: 2400-2411 [PMID:18363350]
ChEMBL Inhibition of COX1 B 4 pIC50 >100000 nM IC50 ACS Med. Chem. Lett. (2011) 2: 353-357 [PMID:24900317]
ChEMBL Inhibition of COX1 by radioimmunoassay method B 4.94 pIC50 11400 nM IC50 J. Nat. Prod. (2007) 70: 795-801 [PMID:17480099]
ChEMBL DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) B 5.38 pIC50 4192 nM IC50 DrugMatrix in vitro pharmacology data
Cyclooxygenase-1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2860] [UniProtKB: O62664]
ChEMBL Inhibition of bovine COX-1 by enzyme immuno assay B 6.46 pIC50 350 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 6855-6861 [PMID:19884005]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL Inhibition of ovine COX1 B 4 pIC50 100000 nM IC50 Bioorg. Med. Chem. (2007) 15: 1014-1021 [PMID:17079150]
ChEMBL Inhibition of ovine COX1 by measuring PGE2 B 4.05 pIC50 90000 nM IC50 Bioorg. Med. Chem. (2007) 15: 6109-6118 [PMID:17604631]
ChEMBL Inhibitory concentration in DMSO with purified ovine Prostaglandin G/H synthase 1 (COX-1). B 4.9 pIC50 12500 nM IC50 J. Med. Chem. (1998) 41: 4800-4818 [PMID:9822550]
ChEMBL Inhibition of Ovine COX-1 preincubated for 15 mins by fluorescence analysis B 5 pIC50 >10000 nM IC50 ACS Med. Chem. Lett. (2015) 6: 1086-1090 [PMID:26487917]
ChEMBL Inhibition of sheep COX1-mediated PGE2 production after 2 mins by liquid scintillation counting B 5.35 pIC50 4500 nM IC50 J. Nat. Prod. (2010) 73: 1763-1766 [PMID:20961090]
ChEMBL Inhibition of ovine COX-1 assessed as inhibition of transformation of AA to PGH2 by EIA B 6.39 pIC50 411 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 6922-6925 [PMID:19880317]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 6.46 pIC50 350 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 584-588 [PMID:19136259]
ChEMBL Inhibition of ovine COX1 B 6.46 pIC50 350 nM IC50 Eur. J. Med. Chem. (2009) 44: 1278-1287 [PMID:18835505]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 6.46 pIC50 350 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 6138-6141 [PMID:18945614]
ChEMBL In vitro inhibition of ovine prostaglandin G/H synthase 1 B 6.46 pIC50 350 nM IC50 J. Med. Chem. (2004) 47: 6108-6111 [PMID:15537365]
ChEMBL Inhibitory activity against ovine COX1 B 6.46 pIC50 350 nM IC50 J. Med. Chem. (2006) 49: 1668-1683 [PMID:16509583]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 6.46 pIC50 350 nM IC50 Bioorg. Med. Chem. (2007) 15: 6796-6801 [PMID:17764958]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 6.46 pIC50 350 nM IC50 Bioorg. Med. Chem. (2008) 16: 1948-1956 [PMID:18023187]
ChEMBL Inhibition of ovine COX1 by enzyme immunoassay B 6.46 pIC50 350 nM IC50 Bioorg. Med. Chem. (2008) 16: 3302-3308 [PMID:18096394]
ChEMBL Inhibition of ovine COX-1 by enzyme immuno assay B 6.46 pIC50 350 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 2154-2159 [PMID:22361134]
ChEMBL Inhibition of ovine COX1 B 6.46 pIC50 350 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 163-168 [PMID:23200247]
ChEMBL Inhibition of ovine COX1 by enzyme immunoassay B 6.52 pIC50 300 nM IC50 Bioorg. Med. Chem. (2009) 17: 5182-5188 [PMID:19500994]
ChEMBL Inhibition of ovine COX1 by enzyme immunoassay B 6.52 pIC50 300 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 1324-1329 [PMID:20097072]
ChEMBL Inhibition of sheep COX1 by enzyme immunoassay B 6.52 pIC50 300 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 4544-4549 [PMID:20576432]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 6.52 pIC50 300 nM IC50 Bioorg. Med. Chem. (2007) 15: 4767-4774 [PMID:17509888]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 6.52 pIC50 300 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6074-6080 [PMID:21890358]
ChEMBL In vitro inhibitory concentration against COX-1 enzyme B 6.52 pIC50 300 nM IC50 J. Med. Chem. (2005) 48: 4061-4067 [PMID:15943479]
ChEMBL Inhibition of ovine COX1 B 6.52 pIC50 300 nM IC50 J. Med. Chem. (2012) 55: 688-696 [PMID:22148253]
ChEMBL Inhibition of ovine COX-1 assessed as reduction in PGF2-alpha formation using arachidonic acid as substrate by enzyme immunoassay B 6.52 pIC50 300 nM IC50 Eur. J. Med. Chem. (2016) 118: 250-258 [PMID:27131067]
ChEMBL Inhibition of ovine COX1 by enzyme immunoassay B 6.52 pIC50 300 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 3014-3018 [PMID:19419861]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 6.52 pIC50 300 nM IC50 Bioorg. Med. Chem. (2008) 16: 9694-9698 [PMID:18930406]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method B 4.28 pKi 52000 nM Ki J. Med. Chem. (2013) 56: 8377-8388 [PMID:24088053]
ChEMBL Inhibition of human recombinant COX2 by measuring PGE2 B 4 pIC50 100000 nM IC50 Bioorg. Med. Chem. (2007) 15: 6109-6118 [PMID:17604631]
ChEMBL Inhibitory concentration in DMSO with purified human Prostaglandin G/H synthase 2 (COX-2) B 4.2 pIC50 62500 nM IC50 J. Med. Chem. (1998) 41: 4800-4818 [PMID:9822550]
ChEMBL Inhibition of COX2 by radioimmunoassay method B 4.7 pIC50 19800 nM IC50 J. Nat. Prod. (2007) 70: 795-801 [PMID:17480099]
ChEMBL Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysis B 5 pIC50 >10000 nM IC50 ACS Med. Chem. Lett. (2015) 6: 1086-1090 [PMID:26487917]
ChEMBL Inhibition of human recombinant COX2 by enzyme immunoassay B 5.62 pIC50 2400 nM IC50 Bioorg. Med. Chem. (2009) 17: 5182-5188 [PMID:19500994]
ChEMBL Inhibition of human recombinant COX2 by enzyme immunoassay B 5.62 pIC50 2400 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 1324-1329 [PMID:20097072]
ChEMBL Inhibition of human COX2 by enzyme immunoassay B 5.62 pIC50 2400 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 4544-4549 [PMID:20576432]
ChEMBL Inhibition of human recombinant COX-2 by enzyme immuno assay B 5.62 pIC50 2400 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 2154-2159 [PMID:22361134]
ChEMBL Inhibition of human recombinant COX2 B 5.62 pIC50 2400 nM IC50 J. Med. Chem. (2012) 55: 688-696 [PMID:22148253]
ChEMBL Inhibition of human recombinant COX2 B 5.62 pIC50 2400 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 163-168 [PMID:23200247]
ChEMBL Inhibition of human recombinant COX-2 by enzyme immuno assay B 5.62 pIC50 2400 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 6855-6861 [PMID:19884005]
GtoPdb - - 5.62 pIC50 2400 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 2494-6 [PMID:22386242]
Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208]
ChEMBL Inhibition of ovine COX2 B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. (2007) 15: 1014-1021 [PMID:17079150]
ChEMBL Inhibition of sheep COX2-mediated PGE2 production after 2 mins by liquid scintillation counting B 4.86 pIC50 13900 nM IC50 J. Nat. Prod. (2010) 73: 1763-1766 [PMID:20961090]
ChEMBL Inhibition of ovine COX-2 assessed as inhibition of transformation of AA to PGH2 by EIA B 5.6 pIC50 2530 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 6922-6925 [PMID:19880317]
ChEMBL Inhibition of ovine COX2 by enzyme immuno assay B 5.62 pIC50 2400 nM IC50 Bioorg. Med. Chem. (2007) 15: 4767-4774 [PMID:17509888]
ChEMBL Inhibition of ovine COX2 by enzyme immuno assay B 5.62 pIC50 2400 nM IC50 Bioorg. Med. Chem. (2007) 15: 6796-6801 [PMID:17764958]
ChEMBL Inhibition of ovine COX2 by enzyme immuno assay B 5.62 pIC50 2400 nM IC50 Bioorg. Med. Chem. (2008) 16: 1948-1956 [PMID:18023187]
ChEMBL Inhibition of ovine COX2 by enzyme immunoassay B 5.62 pIC50 2400 nM IC50 Bioorg. Med. Chem. (2008) 16: 3302-3308 [PMID:18096394]
ChEMBL Inhibition of ovine COX2 by enzyme immuno assay B 5.62 pIC50 2400 nM IC50 Bioorg. Med. Chem. (2008) 16: 9694-9698 [PMID:18930406]
ChEMBL Inhibition of ovine COX2 by enzyme immuno assay B 5.62 pIC50 2400 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 584-588 [PMID:19136259]
ChEMBL Inhibition of ovine COX2 B 5.62 pIC50 2400 nM IC50 Eur. J. Med. Chem. (2009) 44: 1278-1287 [PMID:18835505]
ChEMBL Inhibition of ovine COX2 by enzyme immuno assay B 5.62 pIC50 2400 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 6138-6141 [PMID:18945614]
ChEMBL Inhibition of ovine COX2 by enzyme immunoassay B 5.62 pIC50 2400 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 3014-3018 [PMID:19419861]
ChEMBL Inhibition of ovine COX2 by enzyme immuno assay B 5.62 pIC50 2400 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6074-6080 [PMID:21890358]
ChEMBL In vitro inhibition of ovine prostaglandin G/H synthase 2 B 5.62 pIC50 2400 nM IC50 J. Med. Chem. (2004) 47: 6108-6111 [PMID:15537365]
ChEMBL Inhibition of ovine COX-2 assessed as reduction in PGF2-alpha formation using arachidonic acid as substrate by enzyme immunoassay B 5.62 pIC50 2400 nM IC50 Eur. J. Med. Chem. (2016) 118: 250-258 [PMID:27131067]
ChEMBL In vitro inhibitory concentration against COX-2 enzyme B 5.62 pIC50 2400 nM IC50 J. Med. Chem. (2005) 48: 4061-4067 [PMID:15943479]
ChEMBL Inhibitory activity against ovine COX2 B 5.62 pIC50 2400 nM IC50 J. Med. Chem. (2006) 49: 1668-1683 [PMID:16509583]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Inhibition of EGFR (unknown origin) using tyrosine 4 as substrate by fluorescence analysis B 5 pIC50 >10000 nM IC50 ACS Med. Chem. Lett. (2015) 6: 1086-1090 [PMID:26487917]
Gamma-glutamyltranspeptidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5696] [UniProtKB: P19440]
ChEMBL Inhibition of gamma-glutamyltranspeptidase by colorimetric assay B 4.44 pIC50 36000 nM IC50 Eur. J. Med. Chem. (2009) 44: 197-202 [PMID:18400337]
integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha 2 subunit (CD49B, alpha 2 subunit of VLA-2 receptor)/Integrin alpha-IIb/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2093869] [GtoPdb: 24572440] [UniProtKB: P05106P08514]
ChEMBL Inhibition of collagen-induced platelet aggregation F 4 pIC50 >100000 nM IC50 J. Med. Chem. (1995) 38: 34-41 [PMID:7837237]
ChEMBL Inhibition of arachidonic acid-induced platelet aggregation F 5.3 pIC50 5000 nM IC50 J. Med. Chem. (1995) 38: 34-41 [PMID:7837237]
ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3]
GtoPdb - - 4 pIC50 92000 nM IC50 J. Neurosci. (2001) 21: 8026-33 [PMID:11588175]

ChEMBL data shown on this page come from version 26:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]