ChEMBL ligand: CHEMBL25 (8-hour bayer, Acetosalic Acid, Acetylsalic acid, Acetyl salicylate, Acetylsalicylic acid, Acetylsalicylic Acid, Acetylsalicylic acid (who-ip), Acetylsalicylicum acidum, Acidum acetylsalicylicum, Alka rapid, Anadin all night, Angettes 75, Aspirin, Aspro clr, BAY1019036, Bayer extra strength aspirin for migraine pain, Benzoic acid, 2-(acetyloxy)-, Danamep, Disprin cv, Disprin direct, Durlaza, Ecotrin, Enprin, Equi-Prin, Gencardia, Levius, Max strgh aspro clr, Measurin, Micropirin ec, NSC-27223, NSC-406186, Nu-seals 300, Nu-seals 600, Nu-seals 75, Nu-seals cardio 75, Paynocil, Platet, Platet 300, Postmi 300, Postmi 75, Salicylic Acid Acetate, Vazalore)
COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] Cyclooxygenase-1 in Bovine [ChEMBL: CHEMBL2860] [UniProtKB: O62664] Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979] There should be some charts here, you may need to enable JavaScript!
COX-2 /Cyclooxygenase-2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] Cyclooxygenase-2 in Sheep [ChEMBL: CHEMBL4102] [UniProtKB: P79208] There should be some charts here, you may need to enable JavaScript!
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
Gamma-glutamyltranspeptidase 1 in Human [ChEMBL: CHEMBL5696] [UniProtKB: P19440] There should be some charts here, you may need to enable JavaScript!
integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human [ChEMBL: CHEMBL2093869] [GtoPdb: 2457, 2441] [UniProtKB: P05106, P08514] There should be some charts here, you may need to enable JavaScript!
Nicotinate phosphoribosyltransferase in Human [ChEMBL: CHEMBL4523354] [UniProtKB: Q6XQN6] There should be some charts here, you may need to enable JavaScript!
ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL	Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method	B	4.21	pKi	62000	nM	Ki	J. Med. Chem. (2013) 56: 8377-8388 [PMID:24088053]
GtoPdb	-	-	3.25	pIC50	560100	nM	IC50	Bioorg Med Chem Lett (2009) 19: 6855-61 [PMID:19884005]
ChEMBL	Inhibition of COX1	B	4	pIC50	100000	nM	IC50	J. Med. Chem. (2008) 51: 2400-2411 [PMID:18363350]
ChEMBL	Inhibition of COX1	B	4	pIC50	>100000	nM	IC50	ACS Med. Chem. Lett. (2011) 2: 353-357 [PMID:24900317]
ChEMBL	Inhibition of COX1 by radioimmunoassay method	B	4.94	pIC50	11400	nM	IC50	J. Nat. Prod. (2007) 70: 795-801 [PMID:17480099]
ChEMBL	DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)	B	5.38	pIC50	4192	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of COX1 (unknown origin)	B	6.46	pIC50	350	nM	IC50	ACS Med Chem Lett (2021) 12: 798-804 [PMID:34055228]
Cyclooxygenase-1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2860] [UniProtKB: O62664]
ChEMBL	Inhibition of bovine COX-1 by enzyme immuno assay	B	6.46	pIC50	350	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 6855-6861 [PMID:19884005]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL	Inhibition of ovine COX1	B	4	pIC50	100000	nM	IC50	Bioorg. Med. Chem. (2007) 15: 1014-1021 [PMID:17079150]
ChEMBL	Inhibition of ovine COX1 by measuring PGE2	B	4.05	pIC50	90000	nM	IC50	Bioorg. Med. Chem. (2007) 15: 6109-6118 [PMID:17604631]
ChEMBL	Inhibitory concentration in DMSO with purified ovine Prostaglandin G/H synthase 1 (COX-1).	B	4.9	pIC50	12500	nM	IC50	J. Med. Chem. (1998) 41: 4800-4818 [PMID:9822550]
ChEMBL	Inhibition of Ovine COX-1 preincubated for 15 mins by fluorescence analysis	B	5	pIC50	>10000	nM	IC50	ACS Med. Chem. Lett. (2015) 6: 1086-1090 [PMID:26487917]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay	B	5.21	pIC50	6120	nM	IC50	Eur J Med Chem (2019) 180: 86-98 [PMID:31301566]
ChEMBL	Inhibition of sheep COX1-mediated PGE2 production after 2 mins by liquid scintillation counting	B	5.35	pIC50	4500	nM	IC50	J. Nat. Prod. (2010) 73: 1763-1766 [PMID:20961090]
ChEMBL	Inhibition of ovine COX-1 assessed as inhibition of transformation of AA to PGH2 by EIA	B	6.39	pIC50	411	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 6922-6925 [PMID:19880317]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	6.46	pIC50	350	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 584-588 [PMID:19136259]
ChEMBL	Inhibition of ovine COX-1 by enzyme immuno assay	B	6.46	pIC50	350	nM	IC50	Bioorg. Med. Chem. Lett. (2012) 22: 2154-2159 [PMID:22361134]
ChEMBL	Inhibition of ovine COX1	B	6.46	pIC50	350	nM	IC50	Eur. J. Med. Chem. (2009) 44: 1278-1287 [PMID:18835505]
ChEMBL	Inhibition of ovine COX1	B	6.46	pIC50	350	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 163-168 [PMID:23200247]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	6.46	pIC50	350	nM	IC50	Bioorg. Med. Chem. Lett. (2008) 18: 6138-6141 [PMID:18945614]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	6.46	pIC50	350	nM	IC50	Bioorg. Med. Chem. (2007) 15: 6796-6801 [PMID:17764958]
ChEMBL	In vitro inhibition of ovine prostaglandin G/H synthase 1	B	6.46	pIC50	350	nM	IC50	J. Med. Chem. (2004) 47: 6108-6111 [PMID:15537365]
ChEMBL	Inhibition of ovine COX1 by enzyme immunoassay	B	6.46	pIC50	350	nM	IC50	Bioorg. Med. Chem. (2008) 16: 3302-3308 [PMID:18096394]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	6.46	pIC50	350	nM	IC50	Bioorg. Med. Chem. (2008) 16: 1948-1956 [PMID:18023187]
ChEMBL	Inhibitory activity against ovine COX1	B	6.46	pIC50	350	nM	IC50	J. Med. Chem. (2006) 49: 1668-1683 [PMID:16509583]
ChEMBL	Inhibition of ovine COX1 by enzyme immunoassay	B	6.52	pIC50	300	nM	IC50	Bioorg. Med. Chem. (2009) 17: 5182-5188 [PMID:19500994]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	6.52	pIC50	300	nM	IC50	Bioorg. Med. Chem. (2008) 16: 9694-9698 [PMID:18930406]
ChEMBL	Inhibition of ovine COX1 by enzyme immunoassay	B	6.52	pIC50	300	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 3014-3018 [PMID:19419861]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	6.52	pIC50	300	nM	IC50	Bioorg. Med. Chem. (2007) 15: 4767-4774 [PMID:17509888]
ChEMBL	Inhibition of ovine COX1 by enzyme immunoassay	B	6.52	pIC50	300	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 1324-1329 [PMID:20097072]
ChEMBL	Inhibition of sheep COX1 by enzyme immunoassay	B	6.52	pIC50	300	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 4544-4549 [PMID:20576432]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	6.52	pIC50	300	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 6074-6080 [PMID:21890358]
ChEMBL	Inhibition of ovine COX1	B	6.52	pIC50	300	nM	IC50	J. Med. Chem. (2012) 55: 688-696 [PMID:22148253]
ChEMBL	In vitro inhibitory concentration against COX-1 enzyme	B	6.52	pIC50	300	nM	IC50	J. Med. Chem. (2005) 48: 4061-4067 [PMID:15943479]
ChEMBL	Inhibition of ovine COX-1 assessed as reduction in PGF2-alpha formation using arachidonic acid as substrate by enzyme immunoassay	B	6.52	pIC50	300	nM	IC50	Eur. J. Med. Chem. (2016) 118: 250-258 [PMID:27131067]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL	Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method	B	4.28	pKi	52000	nM	Ki	J. Med. Chem. (2013) 56: 8377-8388 [PMID:24088053]
ChEMBL	Inhibition of human recombinant COX2 by measuring PGE2	B	4	pIC50	100000	nM	IC50	Bioorg. Med. Chem. (2007) 15: 6109-6118 [PMID:17604631]
ChEMBL	Inhibitory concentration in DMSO with purified human Prostaglandin G/H synthase 2 (COX-2)	B	4.2	pIC50	62500	nM	IC50	J. Med. Chem. (1998) 41: 4800-4818 [PMID:9822550]
ChEMBL	Inhibition of COX2 by radioimmunoassay method	B	4.7	pIC50	19800	nM	IC50	J. Nat. Prod. (2007) 70: 795-801 [PMID:17480099]
ChEMBL	Inhibition of recombinant human COX2 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay	B	4.91	pIC50	12360	nM	IC50	Eur J Med Chem (2019) 180: 86-98 [PMID:31301566]
ChEMBL	Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysis	B	5	pIC50	>10000	nM	IC50	ACS Med. Chem. Lett. (2015) 6: 1086-1090 [PMID:26487917]
ChEMBL	Inhibition of human recombinant COX-2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg. Med. Chem. Lett. (2012) 22: 2154-2159 [PMID:22361134]
ChEMBL	Inhibition of human recombinant COX2	B	5.62	pIC50	2400	nM	IC50	J. Med. Chem. (2012) 55: 688-696 [PMID:22148253]
ChEMBL	Inhibition of human recombinant COX2	B	5.62	pIC50	2400	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 163-168 [PMID:23200247]
ChEMBL	Inhibition of COX2 (unknown origin)	B	5.62	pIC50	2400	nM	IC50	ACS Med Chem Lett (2021) 12: 798-804 [PMID:34055228]
ChEMBL	Inhibition of human recombinant COX-2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 6855-6861 [PMID:19884005]
ChEMBL	Inhibition of human recombinant COX2 by enzyme immunoassay	B	5.62	pIC50	2400	nM	IC50	Bioorg. Med. Chem. (2009) 17: 5182-5188 [PMID:19500994]
ChEMBL	Inhibition of human recombinant COX2 by enzyme immunoassay	B	5.62	pIC50	2400	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 1324-1329 [PMID:20097072]
ChEMBL	Inhibition of human COX2 by enzyme immunoassay	B	5.62	pIC50	2400	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 4544-4549 [PMID:20576432]
GtoPdb	-	-	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem Lett (2012) 22: 2494-6 [PMID:22386242]
Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208]
ChEMBL	Inhibition of ovine COX2	B	4	pIC50	>100000	nM	IC50	Bioorg. Med. Chem. (2007) 15: 1014-1021 [PMID:17079150]
ChEMBL	Inhibition of sheep COX2-mediated PGE2 production after 2 mins by liquid scintillation counting	B	4.86	pIC50	13900	nM	IC50	J. Nat. Prod. (2010) 73: 1763-1766 [PMID:20961090]
ChEMBL	Inhibition of ovine COX-2 assessed as inhibition of transformation of AA to PGH2 by EIA	B	5.6	pIC50	2530	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 6922-6925 [PMID:19880317]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg. Med. Chem. (2007) 15: 4767-4774 [PMID:17509888]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg. Med. Chem. (2007) 15: 6796-6801 [PMID:17764958]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg. Med. Chem. (2008) 16: 1948-1956 [PMID:18023187]
ChEMBL	Inhibition of ovine COX2 by enzyme immunoassay	B	5.62	pIC50	2400	nM	IC50	Bioorg. Med. Chem. (2008) 16: 3302-3308 [PMID:18096394]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg. Med. Chem. (2008) 16: 9694-9698 [PMID:18930406]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 584-588 [PMID:19136259]
ChEMBL	Inhibition of ovine COX2	B	5.62	pIC50	2400	nM	IC50	Eur. J. Med. Chem. (2009) 44: 1278-1287 [PMID:18835505]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg. Med. Chem. Lett. (2008) 18: 6138-6141 [PMID:18945614]
ChEMBL	Inhibition of ovine COX2 by enzyme immunoassay	B	5.62	pIC50	2400	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 3014-3018 [PMID:19419861]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 6074-6080 [PMID:21890358]
ChEMBL	Inhibition of ovine COX-2 assessed as reduction in PGF2-alpha formation using arachidonic acid as substrate by enzyme immunoassay	B	5.62	pIC50	2400	nM	IC50	Eur. J. Med. Chem. (2016) 118: 250-258 [PMID:27131067]
ChEMBL	In vitro inhibition of ovine prostaglandin G/H synthase 2	B	5.62	pIC50	2400	nM	IC50	J. Med. Chem. (2004) 47: 6108-6111 [PMID:15537365]
ChEMBL	Inhibition of Ovine COX-2 assessed as decrease in prostaglandin production using arachidonic acid as substrate pretreated for 15 mins followed by substrate addition and measured after 2 mins by enzyme immunoassay	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem Lett (2016) 26: 2893-2899 [PMID:27158139]
ChEMBL	In vitro inhibitory concentration against COX-2 enzyme	B	5.62	pIC50	2400	nM	IC50	J. Med. Chem. (2005) 48: 4061-4067 [PMID:15943479]
ChEMBL	Inhibitory activity against ovine COX2	B	5.62	pIC50	2400	nM	IC50	J. Med. Chem. (2006) 49: 1668-1683 [PMID:16509583]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	Inhibition of EGFR (unknown origin) using tyrosine 4 as substrate by fluorescence analysis	B	5	pIC50	>10000	nM	IC50	ACS Med. Chem. Lett. (2015) 6: 1086-1090 [PMID:26487917]
Gamma-glutamyltranspeptidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5696] [UniProtKB: P19440]
ChEMBL	Inhibition of gamma-glutamyltranspeptidase by colorimetric assay	B	4.44	pIC50	36000	nM	IC50	Eur. J. Med. Chem. (2009) 44: 197-202 [PMID:18400337]
integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2093869] [GtoPdb: 2457, 2441] [UniProtKB: P05106, P08514]
ChEMBL	Inhibition of collagen-induced platelet aggregation	F	4	pIC50	>100000	nM	IC50	J. Med. Chem. (1995) 38: 34-41 [PMID:7837237]
ChEMBL	Inhibition of arachidonic acid-induced platelet aggregation	F	5.3	pIC50	5000	nM	IC50	J. Med. Chem. (1995) 38: 34-41 [PMID:7837237]
Nicotinate phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523354] [UniProtKB: Q6XQN6]
ChEMBL	Inhibition of NAPRT (unknown origin)	B	9.3	pKi	0.5	nM	Ki	WO-2017162840-A1. Sensitization of cancer cells to nampt inhibitors by nicotinic acid phosphoribosyltransferase neutralization (null)
ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3]
GtoPdb	-	-	4	pIC50	92000	nM	IC50	J Neurosci (2001) 21: 8026-33 [PMID:11588175]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]