benzamil [Ligand Id: 4145] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL212579 (Benzamil)
  • ENaC α/Amiloride-sensitive sodium channel alpha-subunit in Human [ChEMBL: CHEMBL1791] [GtoPdb: 738] [UniProtKB: P37088]
  • This target only has 0 pki data point
1 CHEMBL212579_lig_chart_1 Amiloride-sensitive sodium channel alpha-subunit Human
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  • TRPP2 in Human [GtoPdb: 505] [UniProtKB: Q9P0L9]
  • This target only has 0 pki data point
2 CHEMBL212579_lig_chart_2 TRPP2 Human
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  • ASIC1 in Human [GtoPdb: 684] [UniProtKB: P78348]
  • This target only has 0 pki data point
3 CHEMBL212579_lig_chart_3 ASIC1 Human
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  • ENaCαβγ in Human [GtoPdb: 742]
  • This target only has 0 pki data point
4 CHEMBL212579_lig_chart_4 ENaCαβγ Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ENaC α/Amiloride-sensitive sodium channel alpha-subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1791] [GtoPdb: 738] [UniProtKB: P37088]
ChEMBL Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay B 7.18 pIC50 66 nM IC50 J. Med. Chem. (2006) 49: 4098-4115 [PMID:16821771]
TRPP2 in Human [GtoPdb: 505] [UniProtKB: Q9P0L9]
GtoPdb - - 6 pIC50 1100 nM IC50
ASIC1 in Human [GtoPdb: 684] [UniProtKB: P78348]
GtoPdb - - 5 pIC50 10000 nM IC50 Nature (1997) 386: 173-7 [PMID:9062189]
ENaCαβγ in Human [GtoPdb: 742]
GtoPdb - - 8 pIC50 ~10 nM IC50

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]