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ChEMBL ligand: CHEMBL2094089 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
ChEMBL | Binding affinity at adenosine A1 receptor from rat brain membranes by [3H]N6-cyclohexyladenosine displacement. | B | 6.73 | pKi | 188 | nM | Ki | J Med Chem (1988) 31: 1282-1285 [PMID:3385722] |
ChEMBL | Binding affinity at adenosine A1 receptor from rat brain membranes by [3H]N6-cyclohexyladenosine displacement. | B | 6.85 | pKi | 142 | nM | Ki | J Med Chem (1988) 31: 1282-1285 [PMID:3385722] |
ChEMBL | Inhibition of binding of [3H]N6-cyclohexyladenosine to adenosine A1 receptor of rat whole brain membranes. | B | 6.85 | pKi | 142 | nM | Ki | J Med Chem (1989) 32: 1667-1673 [PMID:2754691] |
ChEMBL | Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand | B | 6.85 | pKi | 142 | nM | Ki | J Med Chem (1992) 35: 407-422 [PMID:1738138] |
ChEMBL | Binding affinity at adenosine A1 receptor from rat brain membranes by [3H]N6-cyclohexyladenosine displacement. | B | 6.93 | pKi | 118 | nM | Ki | J Med Chem (1988) 31: 1282-1285 [PMID:3385722] |
ChEMBL | Inhibition of [3H]CHA binding to adenosine A1 receptor from rat brain membranes | B | 6.97 | pKi | 108 | nM | Ki | J Med Chem (1992) 35: 2253-2260 [PMID:1613750] |
ChEMBL | Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand | B | 6.99 | pKi | 103 | nM | Ki | J Med Chem (1992) 35: 241-252 [PMID:1732541] |
ChEMBL | Binding affinity against adenosine A1 receptor from rat brain membranes using [3H]cyclohexyladenosine as radioligand. | B | 7.19 | pKi | 64 | nM | Ki | J Med Chem (1992) 35: 2881-2890 [PMID:1495019] |
Adenosine A1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2304404] [UniProtKB: P47745] | ||||||||
ChEMBL | Prolongation of the stimulus-QRS interval by 50% of the maximum response at the adenosine A1 receptor in langendorff guinea pig heart preparation | F | 5.25 | pEC50 | 5623.41 | nM | EC50 | J Med Chem (1991) 34: 1334-1339 [PMID:2016707] |
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
GtoPdb | - | - | 6.4 | pKi | - | - | - | J Biol Chem (1995) 270: 13987-97 [PMID:7775460] |
ChEMBL | Binding affinity for HA-tagged wild type human Adenosine A2A receptor (WT) using [3H]CGS-21680 as radioligand expressed in COS-7 cells | B | 7.42 | pKi | 38.1 | nM | Ki | J Med Chem (1997) 40: 2588-2595 [PMID:9258366] |
ChEMBL | Binding affinity for HA-tagged mutant human Adenosine A2A receptor (H250N) using [3H]-CGS-21,680 as radioligand expressed in COS-7 cells | B | 7.44 | pKi | 35.9 | nM | Ki | J Med Chem (1997) 40: 2588-2595 [PMID:9258366] |
ChEMBL | Binding affinity for HA-tagged mutant human Adenosine A2A receptor (V84L), using [3H]CGS-21680 as radioligand expressed in COS-7 cells | B | 7.72 | pKi | 18.9 | nM | Ki | J Med Chem (1997) 40: 2588-2595 [PMID:9258366] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]