domoic acid [Ligand Id: 4181] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1232313 (Domoic Acid)
  • GluK2 in Human [GtoPdb: 451] [UniProtKB: Q13002]
  • This target only has 1 pki data point
  • 7.74
1 CHEMBL1232313_lig_chart_1 GluK2 Human
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  • GluK3 in Rat [GtoPdb: 452] [UniProtKB: P42264]
  • This target only has 1 pki data point
  • 8.42
2 CHEMBL1232313_lig_chart_2 GluK3 Rat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GluK2 in Human [GtoPdb: 451] [UniProtKB: Q13002]
GtoPdb Measuring displacement of [3H]Kainate binding by domoate. - 7.74 pKi 18.3 nM Ki J Med Chem (1996) 39: 3617-24 [PMID:8809152]
GluK3 in Rat [GtoPdb: 452] [UniProtKB: P42264]
GtoPdb - - 8.42 pKi 3.84 nM Ki J Med Chem (2008) 51: 4093-103 [PMID:18578478]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]