ChEMBL ligand: CHEMBL570345
CatSper1/Cation channel sperm-associated protein 1 in Human [ChEMBL: CHEMBL1628462] [GtoPdb: 388] [UniProtKB: Q8NEC5] There should be some charts here, you may need to enable JavaScript!
Thioredoxin glutathione reductase in Schistosoma mansoni [ChEMBL: CHEMBL6110] [UniProtKB: Q962Y6] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CatSper1/Cation channel sperm-associated protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628462] [GtoPdb: 388] [UniProtKB: Q8NEC5]
ChEMBL	Inhibition of CatSper1 channel in human sperm assessed as decrease in sperm hyperactivity after 5 mins by computer-assisted sperm analysis	B	4.4	pIC50	40000	nM	IC50	US-20130123310-A1. Modulators of sperm hypermobility and uses thereof (2013)
GtoPdb	-	-	4.7	pIC50	20000	nM	IC50	PLoS ONE (2009) 4: e6844 [PMID:19718436]
Thioredoxin glutathione reductase in Schistosoma mansoni (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6110] [UniProtKB: Q962Y6]
ChEMBL	Inhibition of Schistosoma mansoni TGR	B	7.4	pIC50	40	nM	IC50	J Med Chem (2009) 52: 6474-6483 [PMID:19761212]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]