LY392098 [Ligand Id: 4248] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL341748 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GluA4/Glutamate receptor ionotropic, AMPA 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3190] [GtoPdb: 447] [UniProtKB: P48058] | ||||||||
| ChEMBL | Tested for potentiation towards human iGluR4 receptor expressed in HEK293 cells | F | 5.36 | pEC50 | 4400 | nM | EC50 | J Med Chem (2000) 43: 4354-4358 [PMID:11087558] |
| GtoPdb | - | - | 6.7 | pEC50 | 200 | nM | EC50 | Neuropharmacology (2001) 40: 976-83 [PMID:11406188] |
| GluA1 in Human [GtoPdb: 444] [UniProtKB: P42261] | ||||||||
| GtoPdb | - | - | 5.75 | pEC50 | 1770 | nM | EC50 | Neuropharmacology (2001) 40: 976-83 [PMID:11406188] |
| GluA2 in Human [GtoPdb: 445] [UniProtKB: P42262] | ||||||||
| GtoPdb | - | - | 6.66 | pEC50 | 220 | nM | EC50 | Neuropharmacology (2001) 40: 976-83 [PMID:11406188] |
| GluA3 in Human [GtoPdb: 446] [UniProtKB: P42263] | ||||||||
| GtoPdb | - | - | 5.72 | pEC50 | 1890 | nM | EC50 | Neuropharmacology (2001) 40: 976-83 [PMID:11406188] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
