NPPB [Ligand Id: 4270] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1256759
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  • TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
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  • ClC-7 in Human [GtoPdb: 706] [UniProtKB: P51798]
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  • Maxi Cl- in Human [GtoPdb: 709]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
ChEMBL Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay B 6.22 pEC50 602.56 nM EC50 Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
ChEMBL Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay B 6.22 pEC50 600 nM EC50 Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
GtoPdb FLIPR calcium influx assay - 6.49 pEC50 - - - Biochem Pharmacol (2010) 80: 113-21 [PMID:20226176]
ChEMBL Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by FLIPR analysis B 6.49 pEC50 320 nM EC50 Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
ClC-7 in Human [GtoPdb: 706] [UniProtKB: P51798]
GtoPdb - - 3.8 pIC50 156000 nM IC50 PLoS ONE (2010) 5: e12585 [PMID:20830208]
Maxi Cl- in Human [GtoPdb: 709]
GtoPdb - - 3.8 pIC50 156000 nM IC50 PLoS ONE (2010) 5: e12585 [PMID:20830208]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]